Sci Total Environ. 2023 May 1;871:161914. doi: 10.1016/j.scitotenv.2023.161914. Epub 2023 Jan 31. ABSTRACT BACKGROUND: Phthalate exposure during fetal life may disrupt testicular development. Congruent with this, studies have found shorter anogenital distance, reduced penile size and altered hormone levels in infant boys whose mothers were exposed to higher levels of…
Publications
Publications
Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study
PLoS One. 2023 Feb 2;18(2):e0275123. doi: 10.1371/journal.pone.0275123. eCollection 2023. ABSTRACT BACKGROUND: Celiac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, determine adherence-related factors, and compare adherence to food…
Daily Physical Activity Patterns and Their Associations with Cardiometabolic Biomarkers: The Maastricht Study
Med Sci Sports Exerc. 2023 May 1;55(5):837-846. doi: 10.1249/MSS.0000000000003108. Epub 2022 Dec 27. ABSTRACT PURPOSE: This study aimed to identify physical activity patterns and examine their association with cardiometabolic biomarkers in a cross-sectional design. METHODS: Overall 6072 participants (mean age, 60.2 yr; SD 8.6 yr, 50% women) from The Maastricht…
Probable Sarcopenia, Obesity, and Risk of All-Cause Mortality: A Pooled Analysis of 4,612 Participants
Gerontology. 2023;69(6):706-715. doi: 10.1159/000527804. Epub 2023 Jan 30. ABSTRACT INTRODUCTION: Conflicting evidence exists concerning whether having sarcopenic obesity has additive mortality risk over having only sarcopenia or obesity. We examined the independent and combined associations of obesity and probable sarcopenia with all-cause mortality. METHODS: The pooled analysis included three large,…
Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children
J Pediatr Gastroenterol Nutr. 2023 Feb 1;76(2):218-226. doi: 10.1097/MPG.0000000000003659. Epub 2022 Nov 23. ABSTRACT OBJECTIVES: To evaluate whether a fish oil and/or probiotics intervention in pregnant women with overweight or obesity would influence the tendency of their 24-month-old children to become overweight and alter their body fat percentage. METHODS: Women…
OTTERS: a powerful TWAS framework leveraging summary-level reference data
Nat Commun. 2023 Mar 7;14(1):1271. doi: 10.1038/s41467-023-36862-w. ABSTRACT Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due…
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Diabetes Care. 2023 May 1;46(5):1014-1018. doi: 10.2337/dc22-1359. ABSTRACT OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study,…
Senior Health Clinic for 75-year-old home-dwelling Finns – study design, clinic protocol and non-response analysis
BMC Health Serv Res. 2023 Mar 2;23(1):210. doi: 10.1186/s12913-023-09199-9. ABSTRACT BACKGROUND: In the Finnish policy on older people preventive activities, which maintain functional capacity and independent living, are emphasized. The Turku Senior Health Clinic, aimed at maintaining independent coping of all home-dwelling 75-year-old citizens in the city of Turku, was…
Refining the Definition of Stage 1 Type 1 Diabetes: An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity
Diabetes Care. 2023 Mar 2:dc221960. doi: 10.2337/dc22-1960. Online ahead of print. ABSTRACT OBJECTIVE: To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS: Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set…
Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic
Int J Obes (Lond). 2023 Jun;47(6):453-462. doi: 10.1038/s41366-023-01281-w. Epub 2023 Feb 23. ABSTRACT BACKGROUND/OBJECTIVE: This observational study dissects the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR) and circulating metabolomics using a combination of longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. SUBJECTS/METHODS: Firstly, a data-driven…
