Publications

Eur J Ageing. 2023 Aug 3;20(1):32. doi: 10.1007/s10433-023-00779-6. ABSTRACT STUDY OBJECTIVES: Sleep duration has been shown to associate with cognitive function, but little is known about the short-term effect of sleep duration on the previous night. This study examines how usual sleep duration and previous night’s sleep duration are associated…

Nat Commun. 2023 Aug 2;14(1):4646. doi: 10.1038/s41467-023-39521-2. ABSTRACT Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate…

N Engl J Med. 2023 Aug 3;389(5):474-475. doi: 10.1056/NEJMc2216477. NO ABSTRACT PMID:37530831 | DOI:10.1056/NEJMc2216477…

Psychiatry Res. 2023 Jul 17;326:115355. doi: 10.1016/j.psychres.2023.115355. Online ahead of print. ABSTRACT We investigated whether individuals, who have a high polygenic loading for schizophrenia and major depression (PGL) but have not developed the respective disorders, are still susceptible to experience milder forms of ill-being in terms of job strain or…

J Clin Endocrinol Metab. 2023 Jul 18:dgad418. doi: 10.1210/clinem/dgad418. Online ahead of print. ABSTRACT BACKGROUND & AIMS: The incidence and remission of non-alcoholic fatty liver disease (NAFLD) are sparsely studied outside Asia. This prospective study aimed to investigate NAFLD incidence and remission, and their predictors among a general Finnish population.

Paediatr Perinat Epidemiol. 2023 Jul 11. doi: 10.1111/ppe.12995. Online ahead of print. ABSTRACT BACKGROUND: Life course patterns of change in risk-trajectories-affect health. OBJECTIVES: To examine how trajectories of cardiovascular risk factors are associated with pregnancy and birth outcomes. METHODS: Data from two cohort studies participating in the International Childhood Cardiovascular…

Front Immunol. 2023 Jun 21;14:1157265. doi: 10.3389/fimmu.2023.1157265. eCollection 2023. ABSTRACT IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. We measured…

JIMD Rep. 2023 Jun 20;64(4):293-299. doi: 10.1002/jmd2.12377. eCollection 2023 Jul. ABSTRACT Lysinuric protein intolerance (LPI) is a rare autosomal recessive disorder affecting the transport of cationic amino acids. Elevated plasma zinc concentrations have been described in patients with LPI. Calprotectin is a calcium- and zinc-binding protein, produced by polymorphonuclear leukocytes…

Schizophr Res. 2023 Jun 29;258:9-17. doi: 10.1016/j.schres.2023.06.008. Online ahead of print. ABSTRACT BACKGROUND: Childhood adverse effects and traumatic experiences increase the risk for several psychiatric disorders. We now investigated whether prospectively assessed childhood family environment per se contributes to increased risk for psychotic disorders in adulthood, and whether these family…

Cell Rep Med. 2023 Jun 23:101093. doi: 10.1016/j.xcrm.2023.101093. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study…