Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias

Chemosphere. 2023 Feb;313:137343. doi: 10.1016/j.chemosphere.2022.137343. Epub 2022 Nov 21. ABSTRACT Hypospadias is a congenital malformation of penile urethra with unknown etiology in most cases. Persistent organic pollutant (POP) exposure may disrupt endocrine function during a critical window of development of male genitalia. In animal studies, POPs have been associated with…

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Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study

BMC Endocr Disord. 2022 Nov 18;22(1):284. doi: 10.1186/s12902-022-01197-y. ABSTRACT PURPOSE: To investigate whether exposure to systemic antibiotics influences the risk of developing type 2 diabetes and overweight/obesity. METHODS: The study sample comprised 2209 (110 with incident diabetes) participants from the population-based Cardiovascular Risk in Young Finns Study (YFS) aged 24-39…

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The associations of childhood psychosocial factors with cognitive function in midlife-The young finns study

Neuropsychology. 2023 Jan;37(1):64-76. doi: 10.1037/neu0000877. Epub 2022 Nov 17. ABSTRACT OBJECTIVE: An adverse psychosocial environment in childhood may harm cognitive development, but the associations for adulthood cognitive function remain obscure. We tested the hypothesis that adverse childhood psychosocial factors associate with poor cognitive function in midlife by leveraging the prospective…

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Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization

Neurology. 2023 Feb 7;100(6):e568-e581. doi: 10.1212/WNL.0000000000201489. Epub 2022 Nov 16. ABSTRACT BACKGROUND AND OBJECTIVES: Whether chronic autoimmune inflammatory diseases causally affect the risk of Alzheimer disease (AD) is controversial. We characterized the relationship between inflammatory diseases and risk of AD and explored the role of circulating inflammatory biomarkers in the…

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Changes in life satisfaction during the transition to retirement: findings from the FIREA cohort study

Eur J Ageing. 2022 Nov 23;19(4):1587-1599. doi: 10.1007/s10433-022-00745-8. eCollection 2022 Dec. ABSTRACT Life satisfaction is an essential construct of well-being that is tied to behavioral, emotional, social and psychological outcomes. This study aimed to examine changes in total and domain-specific life satisfaction during the retirement transition and additionally examine whether…

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Meanings Attributed to Physical Activity and Changes in Self-Reported and Accelerometer-Measured Physical Activity among Recent Retirees

Int J Environ Res Public Health. 2022 Nov 23;19(23):15567. doi: 10.3390/ijerph192315567. ABSTRACT Retirement poses opportunities and challenges for maintaining and adopting physically active habits, which may have major implications for health and functional ability in later life. Qualitative studies suggest that a broad range of meanings of physical activity should…

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Treatment of congenital hypothyroidism – impact of secular changes in levothyroxine initial dose on early growth

Horm Res Paediatr. 2022 Dec 7. doi: 10.1159/000528567. Online ahead of print. ABSTRACT INTRODUCTION: Newborn screening of congenital hypothyroidism (CH) has enabled early treatment with levothyroxine (LT4), ensuring normal growth and development. The initial LT4 dose recommendation has increased over decades. We evaluated whether the increased LT4 dosing influenced thyroid-stimulating…

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