Publications

PLoS One. 2022 Dec 1;17(12):e0278405. doi: 10.1371/journal.pone.0278405. eCollection 2022. ABSTRACT BACKGROUND: Physical activity and body mass index (BMI) have been reported to change around retirement. The objective was to examine the concurrent changes in physical activity and BMI around retirement, which have not been studied before. In addition, the associations…

Nature. 2022 Oct;610(7933):704-712. doi: 10.1038/s41586-022-05275-y. Epub 2022 Oct 12. ABSTRACT Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals…

Circulation. 2023 Jan 3;147(1):23-31. doi: 10.1161/CIRCULATIONAHA.122.060667. Epub 2022 Nov 28. ABSTRACT BACKGROUND: Elevated lipoprotein(a) [Lp(a)] is a common risk factor for cardiovascular disease outcomes with unknown mechanisms. We examined its potential role in identifying youths who are at increased risk of developing adult atherosclerotic cardiovascular disease (ASCVD). METHODS: Lp(a) levels…

Schizophrenia (Heidelb). 2022 Oct 11;8(1):82. doi: 10.1038/s41537-022-00282-4. ABSTRACT Abnormal glucose and lipid metabolism is common in antipsychotic-naive first-episode patients with schizophrenia, but it is unclear whether these changes can already be seen in premorbid or prodromal period, before the first psychotic episode. We examined insulin, total cholesterol, low-density lipoprotein (LDL)…

Nutrients. 2022 Nov 18;14(22):4891. doi: 10.3390/nu14224891. ABSTRACT Parental self-efficacy (PSE), a measure of the subjective competence in the parental role, has been linked with child well-being and health. Research on the influence of PSE on child eating habits is scarce, and the few studies have concentrated on certain food groups,…

Chemosphere. 2023 Feb;313:137343. doi: 10.1016/j.chemosphere.2022.137343. Epub 2022 Nov 21. ABSTRACT Hypospadias is a congenital malformation of penile urethra with unknown etiology in most cases. Persistent organic pollutant (POP) exposure may disrupt endocrine function during a critical window of development of male genitalia. In animal studies, POPs have been associated with…

BMC Endocr Disord. 2022 Nov 18;22(1):284. doi: 10.1186/s12902-022-01197-y. ABSTRACT PURPOSE: To investigate whether exposure to systemic antibiotics influences the risk of developing type 2 diabetes and overweight/obesity. METHODS: The study sample comprised 2209 (110 with incident diabetes) participants from the population-based Cardiovascular Risk in Young Finns Study (YFS) aged 24-39…

Int J Mol Sci. 2022 Dec 11;23(24):15726. doi: 10.3390/ijms232415726. ABSTRACT Only 3-5% of heavy alcohol users develop acute alcohol pancreatitis (AAP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AAP, and SPINK1 mutation is a documented risk factor. We…

PLoS One. 2022 Dec 20;17(12):e0279384. doi: 10.1371/journal.pone.0279384. eCollection 2022. ABSTRACT Emerging evidence suggests that exposure to unpredictable patterns of maternal sensory signals during infancy is associated with child neurodevelopment, including poorer effortful control. However, longitudinal effects on child development and possible sex differences are understudied. The aims of the present…

Front Endocrinol (Lausanne). 2022 Nov 25;13:1028828. doi: 10.3389/fendo.2022.1028828. eCollection 2022. ABSTRACT INTRODUCTION: Constitutional delay of growth and puberty (CDGP) is the most common reason for delayed puberty in healthy male adolescents. The main indication for medical treatment for this condition is psychosocial burden. However, to the best of our knowledge,…