J Med Virol. 2023 Apr;95(4):e28707. doi: 10.1002/jmv.28707. ABSTRACT This study investigated whether children with HLA-DQ-conferred risk for type 1 diabetes (T1D) have an altered immune response to the widely-used enterovirus vaccine, namely poliovirus vaccine, and whether initiation of autoimmunity to pancreatic islets modulates this response. Neutralizing antibodies induced by the…
Publications
Publications
Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum
Metabolomics. 2023 Mar 24;19(4):20. doi: 10.1007/s11306-023-01994-z. ABSTRACT INTRODUCTION: Aberrations in circulating metabolites have been associated with diabetes and cardiovascular risk. OBJECTIVES: To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic. METHODS: An NMR…
Sex differences, asymmetry, and age-related white matter development in infants and 5-year-olds as assessed with tract-based spatial statistics
Hum Brain Mapp. 2023 May;44(7):2712-2725. doi: 10.1002/hbm.26238. Epub 2023 Mar 22. ABSTRACT The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and…
Stress-Related Exhaustion, Polygenic Cognitive Potential, and Cognitive Test Performance – A General Population Study
Cognit Ther Res. 2023;47(2):155-167. doi: 10.1007/s10608-023-10354-z. Epub 2023 Feb 4. ABSTRACT BACKGROUND: We investigated whether stress-related exhaustion (chronic or short-term, and co-occurring with depression or not) is related to cognitive performance and whether polygenic cognitive potential modifies these associations. METHODS: The participants were from the Young Finns Study (N =…
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study
BMJ Med. 2023 Feb 14;2(1):e000157. doi: 10.1136/bmjmed-2022-000157. eCollection 2023. ABSTRACT OBJECTIVE: To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. DESIGN: Bi-directional Mendelian randomisation study. SETTING: Genome-wide association studies from three Finnish cohorts (Northern Finland Birth…
Childhood Dyslipidemia and Carotid Atherosclerotic Plaque in Adulthood: The Cardiovascular Risk in Young Finns Study
J Am Heart Assoc. 2023 Apr 4;12(7):e027586. doi: 10.1161/JAHA.122.027586. Epub 2023 Mar 16. ABSTRACT Background Childhood exposure to dyslipidemia is associated with adult atherosclerosis, but it is unclear whether the long-term risk associated with dyslipidemia is attenuated on its resolution by adulthood. We aimed to address this question by examining…
Factors influencing vulnerability to climate change-related health impacts in cities – A conceptual framework
Environ Int. 2023 Mar;173:107837. doi: 10.1016/j.envint.2023.107837. Epub 2023 Feb 18. ABSTRACT Climate change will have adverse impacts on human health, which are amplified in cities. For these impacts, there are direct, indirect, and deferred pathways. The first category is well-studied, while indirect and deferred impacts are not well-understood. Moreover, the…
Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts
Pediatr Allergy Immunol. 2023 Apr;34(4):e13945. doi: 10.1111/pai.13945. ABSTRACT BACKGROUND: Urban-related nature exposures are suggested to contribute to the rising prevalence of allergic diseases despite little supporting evidence. Our aim was to evaluate the impact of 12 land cover classes and two greenness indices around homes at birth on the development…
Spillover effects of the COVID-19 pandemic on attitudes to influenza and childhood vaccines
BMC Public Health. 2023 Apr 25;23(1):764. doi: 10.1186/s12889-023-15653-4. ABSTRACT The current study sought to determine whether public perceptions of other vaccines and diseases than COVID-19 have been impacted by the COVID-19 pandemic. We longitudinally examined whether there had been a change from before the COVID-19 pandemic to during the pandemic…
What is the role of puberty in the development of islet autoimmunity and progression to type 1 diabetes?
Eur J Epidemiol. 2023 Jun;38(6):689-697. doi: 10.1007/s10654-023-01002-7. Epub 2023 Apr 20. ABSTRACT In many populations, the peak period of incidence of type 1 diabetes (T1D) has been observed to be around 10-14 years of age, coinciding with puberty, but direct evidence of the role of puberty in the development of…
