Publications

Semin Reprod Med. 2024 Feb 12. doi: 10.1055/s-0044-1779726. Online ahead of print. ABSTRACT Male reproductive functions are strictly regulated in order to maintain sperm production and fertility. All processes are controlled by precise regulation of gene expression, which creates specific gene expression programs for different developmental stages and cell types,…

Eur J Pediatr. 2024 Jan 31. doi: 10.1007/s00431-024-05445-2. Online ahead of print. NO ABSTRACT PMID:38294516 | DOI:10.1007/s00431-024-05445-2…

Int J Obes (Lond). 2024 Jan 25. doi: 10.1038/s41366-024-01466-x. Online ahead of print. ABSTRACT BACKGROUND: Metabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors remains unclear. METHODS: Two independent discovery cohorts, consisting of twins and unrelated individuals, were examined (N…

Psychoneuroendocrinology. 2024 Jan 4;162:106955. doi: 10.1016/j.psyneuen.2023.106955. Online ahead of print. ABSTRACT Maternal prenatal distress can participate in the programming of offspring development, in which exposure to altered maternal long-term cortisol levels as measured by hair cortisol concentrations (HCC) may contribute. Yet, studies investigating whether and how maternal prenatal HCC associates…

Nat Commun. 2024 Jan 18;15(1):586. doi: 10.1038/s41467-024-44709-1. ABSTRACT X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the…

Genome Biol. 2024 Jan 16;25(1):22. doi: 10.1186/s13059-023-03136-z. ABSTRACT BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated…

J Nutr. 2024 Jan 12:S0022-3166(24)00027-0. doi: 10.1016/j.tjnut.2024.01.008. Online ahead of print. ABSTRACT BACKGROUND: Dietary fiber is an important health-promoting component of the diet, which is fermented by the gut microbes that produce metabolites beneficial for the host’s health. OBJECTIVE: We studied the associations of habitual long-term fiber intake from infancy…

J Affect Disord. 2024 Jan 11:S0165-0327(24)00103-4. doi: 10.1016/j.jad.2024.01.093. Online ahead of print. ABSTRACT BACKGROUND: A great number of case-control and population-based studies have shown that depression patients differ from healthy controls in their temperament traits. We investigated whether polygenic risk for depression predicts trajectories of temperament traits from early adulthood…

J Affect Disord. 2024 Jan 4:S0165-0327(23)01544-6. doi: 10.1016/j.jad.2023.12.076. Online ahead of print. ABSTRACT Maternal symptoms of depression and anxiety during pregnancy and early postnatal years are suggested to impose differential negative effects on child’s socio-emotional development depending on the characteristics of the symptoms, such as timing, intensity, and persistence. The…

Environ Health Perspect. 2023 Dec;131(12):127020. doi: 10.1289/EHP12080. Epub 2023 Dec 27. ABSTRACT BACKGROUND: Climate change scenarios illustrate various pathways in terms of global warming ranging from “sustainable development” (Shared Socioeconomic Pathway SSP1-1.9), the best-case scenario, to ‘fossil-fueled development’ (SSP5-8.5), the worst-case scenario. OBJECTIVES: We examined the extent to which increase…