Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

Epigenomics. 2022 Oct 5. doi: 10.2217/epi-2022-0228. Online ahead of print. ABSTRACT Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results:…

Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children

Diabetologia. 2022 Oct 5. doi: 10.1007/s00125-022-05799-y. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: The aim of this study was to explore the utility of islet autoantibody (IAb) levels for the prediction of type 1 diabetes in autoantibody-positive children. METHODS: Prospective cohort studies in Finland, Germany, Sweden and the USA followed 24,662…

Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis

Reproduction. 2022 Oct 1:REP-22-0240. doi: 10.1530/REP-22-0240. Online ahead of print. ABSTRACT Heterochromatin is dynamically formed and organized in differentiating male germ cells, and its proper regulation is a prerequisite for normal spermatogenesis. While heterochromatin is generally transcriptionally silent, we have previously shown that major satellite repeat (MSR) DNA in the…

Maternal sensitivity at the age of 8 months associates with local connectivity of the medial prefrontal cortex in children at 5 years of age

Front Neurosci. 2022 Sep 15;16:920995. doi: 10.3389/fnins.2022.920995. eCollection 2022. ABSTRACT The quality of mother-child interaction, especially maternal sensitivity in caregiving behavior, plays an important role in a child’s later socioemotional development. Numerous studies have indicated associations between poor mother-child interaction and offspring brain structure and function, but more knowledge on…

Associations between observed and reported infant negative affectivity, fear and self-regulation, and early communicative development-Evidence from the FinnBrain Birth Cohort Study

Infancy. 2022 Sep 29. doi: 10.1111/infa.12508. Online ahead of print. ABSTRACT Self-regulation and language are intertwined abilities, but the nature of their relations in early childhood when both skills are still emerging is insufficiently understood. Our knowledge of the relations between early negative affectivity and preverbal and verbal communicative development…

Association of sleep with cognitive function during retirement transition: The Whitehall II Study

Sleep. 2022 Sep 27:zsac237. doi: 10.1093/sleep/zsac237. Online ahead of print. ABSTRACT STUDY OBJECTIVES: Sleep duration and difficulties have been shown to associate with cognitive function. This study examined how changes in sleep and in cognitive function are associated during retirement transition. METHODS: The study population consisted of 2,980 Whitehall II…

Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests

Diabetes Care. 2022 Oct 1;45(10):2342-2349. doi: 10.2337/dc22-0828. ABSTRACT OBJECTIVE: Biomarkers predicting risk of type 1 diabetes (stage 3) among children with islet autoantibodies are greatly needed to prevent diabetic ketoacidosis and facilitate prevention therapies. RESEARCH DESIGN AND METHODS: Children in the prospective The Environmental Determinants of Diabetes in the Young…

Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study

Diabetes Care. 2022 Oct 1;45(10):2271-2281. doi: 10.2337/dc21-2612. ABSTRACT OBJECTIVE: To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. RESEARCH DESIGN AND METHODS: Genetically high-risk newborns (n = 8,502) were followed for a median of 11.2 years (interquartile range…

Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals with Presymptomatic Type 1 Diabetes

Diabetes. 2022 Sep 16:db220360. doi: 10.2337/db22-0360. Online ahead of print. ABSTRACT Our previous data-driven analysis of evolving patterns of islet autoantibodies (IAbs) against insulin (IAA), glutamic acid decarboxylase (GADA) and islet antigen 2 (IA-2A) discovered three trajectories characterized by either multiple IAbs (TR1), IAA (TR2), or GADA (TR3) as the…

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