Insomnia and sleepiness during pregnancy: Associations with gestational diabetes mellitus

Acta Obstet Gynecol Scand. 2025 Jul 11. doi: 10.1111/aogs.70013. Online ahead of print. ABSTRACT INTRODUCTION: Sleep quality typically deteriorates during pregnancy, and poor sleep is a risk factor for pregnancy complications, including gestational diabetes mellitus (GDM). The present study is the first longitudinal study addressing associations between sleep quality and…

The associations between intergenerational mobility of income and cognitive function in midlife-The Young Finns Study

Soc Sci Med. 2025 Jun 27;382:118325. doi: 10.1016/j.socscimed.2025.118325. Online ahead of print. ABSTRACT BACKGROUND: Systematically high and upward mobile (lower childhood and higher adulthood) socioeconomic status (SES) has been suggested to be associated with better overall cognitive function in adulthood compared to systematically low or downward mobile (high childhood and…

NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis

Nat Commun. 2025 Jul 7;16(1):6254. doi: 10.1038/s41467-025-61463-0. ABSTRACT In eukaryotes, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, NXT1 has an X-chromosomal paralog, NXT2, which exhibits testis-enriched expression, suggesting a role in spermatogenesis. Here, we report the…

Concurrent Changes in 24-Hour Movement Behaviors and Cognitive Function during Retirement Transition: Longitudinal Compositional Data Analysis

Med Sci Sports Exerc. 2025 Jul 4. doi: 10.1249/MSS.0000000000003801. Online ahead of print. ABSTRACT BACKGROUND: Transitioning to retirement may change physical activity, sedentary behavior, and sleep, i.e., 24-h movement behaviors, but it is unknown whether these changes are linked to cognitive function. This study investigates the longitudinal associations between changes…

Paternal adverse childhood experiences and offspring’s attentional disengagement from faces at 8 months-Results from the FinnBrain Birth Cohort Study

PLoS One. 2025 Jul 3;20(7):e0326437. doi: 10.1371/journal.pone.0326437. eCollection 2025. ABSTRACT Paternal adverse childhood experiences (ACEs) have been recently linked to offspring’s brain development. Yet, none of the previous studies in humans have explored the association between paternal ACEs and a child’s attentional bias for facial expressions of emotion. Our study…

Does accelerometer-measured physical activity and sedentary time differ between manual, in-office, hybrid and remote workers?

Occup Environ Med. 2025 Jun 25:oemed-2025-110105. doi: 10.1136/oemed-2025-110105. Online ahead of print. ABSTRACT OBJECTIVES: Studies on accelerometer-measured daily physical activity behaviour, especially among hybrid and remote workers, are scarce. We compared daily occupational and non-occupational physical activity and sedentary time among manual, in-office, hybrid and remote workers. In addition, physical…

Maternal and umbilical cord serum lipids in gestational diabetes predict offspring insulin secretion and resistance at the age of nine years

Metabolomics. 2025 Jun 22;21(4):87. doi: 10.1007/s11306-025-02281-9. ABSTRACT INTRODUCTION: Maternal metabolism in pregnancy is a major determinant of intrauterine milieu and is assumed to have long-term consequences in the offspring. OBJECTIVES: To study whether maternal or cord serum lipids are related to measures of insulin resistance and β-cell function in childhood.

The Frequency but not the Phenotype of Circulating Peripheral T Helper Cells is Increased at Later Stages of Progression to Type 1 Diabetes

Eur J Immunol. 2025 Jun;55(6):e51704. doi: 10.1002/eji.202451704. ABSTRACT Circulating follicular (cTfh) and peripheral (cTph) T helper cells have been demonstrated to be expanded in several autoimmune diseases, including type 1 diabetes (T1D). Here, we examined the frequencies and phenotypes of these cells at different stages of T1D development and addressed…

Changes in life satisfaction and leisure-time physical activity across retirement transition: the FIREA cohort study

Eur J Ageing. 2025 Jun 17;22(1):29. doi: 10.1007/s10433-025-00865-x. ABSTRACT Retirement brings changes in daily life, which may have implications for life satisfaction and leisure-time physical activity (LTPA). This study sought to examine associations between concurrent changes in life satisfaction and LTPA across retirement, addressing gaps in understanding how life satisfaction…

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