Morbidity-bridging metabolic pathways: linking early cardiovascular disease risk and depression symptoms using a multi-modal approach

Eur Heart J Open. 2025 Apr 16;5(3):oeaf038. doi: 10.1093/ehjopen/oeaf038. eCollection 2025 May. ABSTRACT AIMS: Prevalence of cardiovascular diseases (CVDs) and depression is rising globally. Their co-occurrence associates with poorer outcomes, potentially due to shared metabolic pathways. This study aimed to identify metabolic pathways linking depression symptoms and CVD risk factors.

Polygenic risk for schizophrenia and subjective well-being in a general population sample

Psychol Med. 2025 May 2;55:e133. doi: 10.1017/S0033291725000911. ABSTRACT BACKGROUND: Previous evidence has reported associations of a polygenic risk score for schizophrenia (PRSSCZ) with negative developmental outcomes, such as psychiatric symptoms, adverse health behaviors, and reduced everyday functioning. We now investigated the relationship of PRSSCZ with subjectively experienced well-being. METHODS: Participants…

Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases

Clin Epigenetics. 2025 Apr 29;17(1):68. doi: 10.1186/s13148-025-01871-7. ABSTRACT Non-coding 886 (nc886, vtRNA2-1) is a polymorphically imprinted gene. The methylation status of this locus has been shown to be associated with periconceptional conditions, and both the methylation status and the levels of nc886 RNAs have been shown to associate with later-life…

Association of multimorbidity with working life expectancy among adults aged 50 years and older: Findings from two prospective cohort studies

J Multimorb Comorb. 2025 Apr 15;15:26335565251331187. doi: 10.1177/26335565251331187. eCollection 2025 Jan-Dec. ABSTRACT BACKGROUND: Individual diseases are important risk factors for early exit from the labour force among older adults, but the contribution of multimorbidity to working life expectancy (WLE) is unclear. METHODS: We used data from two prospective cohort studies:…

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