Scand J Public Health. 2024 Aug 17:14034948241262185. doi: 10.1177/14034948241262185. Online ahead of print. ABSTRACT AIMS: Childhood family environment is associated with adulthood health behaviours and cardiovascular health, but limited data are available concerning the relationship between childhood family environment and adulthood haemodynamic determinants of blood pressure. We evaluated how childhood…
Publications
Publications
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis
BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. doi: 10.1136/bmjresp-2023-001630. ABSTRACT OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis…
A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations
Res Sq [Preprint]. 2024 Jul 17:rs.3.rs-4163414. doi: 10.21203/rs.3.rs-4163414/v1. ABSTRACT Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for…
The effect of early life cytomegalovirus infection on the immune profile of children
Clin Immunol. 2024 Jul 25:110330. doi: 10.1016/j.clim.2024.110330. Online ahead of print. ABSTRACT Cytomegalovirus (CMV) infection has a life-long impact on the immune system, particularly on memory T cells. However, the effect of early life CMV infection on the phenotype and functionality of T cells in infants and especially longitudinal changes…
Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth
Int J Cancer. 2024 Jul 22. doi: 10.1002/ijc.35098. Online ahead of print. ABSTRACT Zona pellucida 3 (ZP3) expression is classically found in the ZP-layer of the oocytes, lately shown in ovarian and prostate cancer. A successful ZP3 ovarian cancer immunotherapy in transgenic mice suggested its use as an attractive therapeutic…
Stimulating leisure-time activities and the risk of dementia: a multi-cohort study
Age Ageing. 2024 Jul 2;53(7):afae141. doi: 10.1093/ageing/afae141. ABSTRACT BACKGROUND: Stimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with…
Early appearance of thyroid autoimmunity in children followed from birth for type 1 diabetes risk
J Clin Endocrinol Metab. 2024 Jul 12:dgae478. doi: 10.1210/clinem/dgae478. Online ahead of print. ABSTRACT PURPOSE: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for…
Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature
Eur Heart J. 2024 Jul 12:ehae423. doi: 10.1093/eurheartj/ehae423. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Retinal microvasculature characteristics predict cardiovascular morbidity and mortality. This study investigated associations of lifelong cardiovascular risk factors and effects of dietary intervention on retinal microvasculature in young adulthood. METHODS: The cohort is derived from…
Paternal adverse childhood experiences are associated with a low risk of atopy in the offspring
Acta Paediatr. 2024 Jul 11. doi: 10.1111/apa.17345. Online ahead of print. ABSTRACT AIM: Parental adverse childhood experiences (ACE) might affect the offspring health through intergenerational inheritance. The aim of this study was to investigate how paternal ACE associate with offspring sensitisation and allergic rhinitis (AR). METHODS: The study included 590…
Consortium Profile: The Methylation, Imaging and NeuroDevelopment (MIND) Consortium
medRxiv [Preprint]. 2024 Jun 25:2024.06.23.24309353. doi: 10.1101/2024.06.23.24309353. ABSTRACT Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain…
