Diabetes Care. 2023 Aug 14:dc230417. doi: 10.2337/dc23-0417. Online ahead of print. ABSTRACT OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic…
Publications
Publications
Latent profile analysis of diurnal cortisol patterns at the ages of 2, 3.5, and 5 years: Associations with childcare setting, child individual characteristics, and maternal distress
Psychoneuroendocrinology. 2023 Jul 29;156:106345. doi: 10.1016/j.psyneuen.2023.106345. Online ahead of print. ABSTRACT This study performed latent profile analysis from more than 4000 saliva cortisol samples collected from children at the ages of 2 (T1), 3.5 (T2), and 5 years (T3). Three clearly different cortisol profiles were identified. The largest group at…
The association of previous night’s sleep duration with cognitive function among older adults: a pooled analysis of three Finnish cohorts
Eur J Ageing. 2023 Aug 3;20(1):32. doi: 10.1007/s10433-023-00779-6. ABSTRACT STUDY OBJECTIVES: Sleep duration has been shown to associate with cognitive function, but little is known about the short-term effect of sleep duration on the previous night. This study examines how usual sleep duration and previous night’s sleep duration are associated…
Genetic insights into resting heart rate and its role in cardiovascular disease
Nat Commun. 2023 Aug 2;14(1):4646. doi: 10.1038/s41467-023-39521-2. ABSTRACT Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate…
SARS-CoV-2 – No Increased Islet Autoimmunity or Type 1 Diabetes in Teens
N Engl J Med. 2023 Aug 3;389(5):474-475. doi: 10.1056/NEJMc2216477. NO ABSTRACT PMID:37530831 | DOI:10.1056/NEJMc2216477…
Polygenic liabilities underlying job stress and exhaustion over a 10-year follow-up: A general population study
Psychiatry Res. 2023 Jul 17;326:115355. doi: 10.1016/j.psychres.2023.115355. Online ahead of print. ABSTRACT We investigated whether individuals, who have a high polygenic loading for schizophrenia and major depression (PGL) but have not developed the respective disorders, are still susceptible to experience milder forms of ill-being in terms of job strain or…
Non-alcoholic fatty liver disease incidence and remission and their predictors during 7 years follow-up among Finns
J Clin Endocrinol Metab. 2023 Jul 18:dgad418. doi: 10.1210/clinem/dgad418. Online ahead of print. ABSTRACT BACKGROUND & AIMS: The incidence and remission of non-alcoholic fatty liver disease (NAFLD) are sparsely studied outside Asia. This prospective study aimed to investigate NAFLD incidence and remission, and their predictors among a general Finnish population.
Trajectories of cardiovascular risk predict pregnancy outcomes: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study
Paediatr Perinat Epidemiol. 2023 Jul 11. doi: 10.1111/ppe.12995. Online ahead of print. ABSTRACT BACKGROUND: Life course patterns of change in risk-trajectories-affect health. OBJECTIVES: To examine how trajectories of cardiovascular risk factors are associated with pregnancy and birth outcomes. METHODS: Data from two cohort studies participating in the International Childhood Cardiovascular…
Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression
Front Immunol. 2023 Jun 21;14:1157265. doi: 10.3389/fimmu.2023.1157265. eCollection 2023. ABSTRACT IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. We measured…
Plasma calprotectin is extremely high in patients with lysinuric protein intolerance
JIMD Rep. 2023 Jun 20;64(4):293-299. doi: 10.1002/jmd2.12377. eCollection 2023 Jul. ABSTRACT Lysinuric protein intolerance (LPI) is a rare autosomal recessive disorder affecting the transport of cationic amino acids. Elevated plasma zinc concentrations have been described in patients with LPI. Calprotectin is a calcium- and zinc-binding protein, produced by polymorphonuclear leukocytes…
