Prediction of pre-diabetes and type 2 diabetes nine years postpartum using serum metabolome in pregnant women with gestational diabetes requiring pharmacological treatment

J Diabetes Complications. 2023 Jul;37(7):108513. doi: 10.1016/j.jdiacomp.2023.108513. Epub 2023 May 26. ABSTRACT AIMS: We examined the association between serum metabolome in women with pharmacologically treated gestational diabetes (GDM) and measures of glucose metabolism 9 years postpartum. METHODS: Serum targeted metabolome, adiponectin, inflammatory markers, and insulin-like growth factor-binding protein-1 phosphoisoforms were…

Hair cortisol, cortisone and DHEA concentrations and the composition of microbiota in toddlers

Psychoneuroendocrinology. 2023 Aug;154:106309. doi: 10.1016/j.psyneuen.2023.106309. Epub 2023 May 25. ABSTRACT Animal research suggests that the gut microbiota and the HPA axis communicate in a bidirectional manner. However, human data, especially on early childhood, remain limited. In this exploratory design, we investigated the connections between long-term HPA axis functioning, measured as…

Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis

Epigenetics. 2023 Dec;18(1):2211361. doi: 10.1080/15592294.2023.2211361. ABSTRACT BACKGROUND: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. METHODS: We meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association…

Investigating the role of relationship satisfaction and paternal psychological distress during pregnancy on offspring health in early life

BJPsych Open. 2023 May 25;9(3):e100. doi: 10.1192/bjo.2023.59. ABSTRACT BACKGROUND: The research on the role of father in the foetal programming of health and behaviour has received increasing attention. However, the influences of paternal depressive symptoms and couple relationship satisfaction during pregnancy – potentially mediated via maternal well-being – on the…

Modifications of 24-h movement behaviors to prevent obesity in retirement: a natural experiment using compositional data analysis

Int J Obes (Lond). 2023 May 23. doi: 10.1038/s41366-023-01326-0. Online ahead of print. ABSTRACT BACKGROUND: Retirement often leads to a more passive lifestyle and may therefore lead to weight gain. This study aims to investigate longitudinal associations between changes in 24-h movement behaviors and BMI and waist circumference in relation…

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