Eur J Endocrinol. 2023 Apr 4;188(4):K17-K23. doi: 10.1093/ejendo/lvad034. ABSTRACT The aim of this study was to describe the course of puberty and hypogonadism in males with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a Finnish APECED cohort followed up between 1970 and 2020. Anthropometry, testicular volumes and FSH, LH, and testosterone concentrations…
Publications
Publications
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Nat Genet. 2023 Mar;55(3):410-422. doi: 10.1038/s41588-023-01314-0. Epub 2023 Mar 13. ABSTRACT Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria…
What is the role of puberty in the development of islet autoimmunity and progression to type 1 diabetes?
Eur J Epidemiol. 2023 Jun;38(6):689-697. doi: 10.1007/s10654-023-01002-7. Epub 2023 Apr 20. ABSTRACT In many populations, the peak period of incidence of type 1 diabetes (T1D) has been observed to be around 10-14 years of age, coinciding with puberty, but direct evidence of the role of puberty in the development of…
Prenatal maternal depressive symptoms are associated with neonatal left amygdala microstructure in a sex-dependent way
Eur J Neurosci. 2023 May;57(10):1671-1688. doi: 10.1111/ejn.15989. Epub 2023 May 2. ABSTRACT Exposures to prenatal maternal depressive symptoms (PMDS) may lead to neurodevelopmental changes in the offspring in a sex-dependent way. Although a connection between PMDS and infant brain development has been established by earlier studies, the relationship between PMDS…
Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system
Dev Psychopathol. 2023 Apr 3:1-16. doi: 10.1017/S0954579423000275. Online ahead of print. ABSTRACT Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap.
Association of Sit-to-Stand Capacity and Free-Living Performance Using Thigh-Worn Accelerometers among 60-90-Year-Old Adults
Med Sci Sports Exerc. 2023 Apr 3. doi: 10.1249/MSS.0000000000003178. Online ahead of print. ABSTRACT PURPOSE: Five times sit-to-stand (STS) test is commonly used as a clinical assessment of lower-extremity functional ability, but its association with free-living performance has not been studied. Therefore, we investigated the association between laboratory-based STS capacity…
Higher attention bias for fear at 8 months of age is associated with better socioemotional competencies during toddlerhood
Infant Behav Dev. 2023 May;71:101838. doi: 10.1016/j.infbeh.2023.101838. Epub 2023 Mar 28. ABSTRACT BACKGROUND: In previous studies, an attention bias for signals of fear and threat has been related to socioemotional problems, such as anxiety symptoms, and socioemotional competencies, such as altruistic behaviors in children, adolescents and adults. However, previous studies…
Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative
Toxics. 2023 Mar 4;11(3):241. doi: 10.3390/toxics11030241. ABSTRACT Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from…
Pre- and postnatal maternal depressive symptoms associate with white matter integrity in 5-year-olds in sex-specific manner
Biol Psychiatry. 2023 May 21:S0006-3223(23)01301-X. doi: 10.1016/j.biopsych.2023.05.014. Online ahead of print. ABSTRACT BACKGROUND: Pre- and postnatal maternal psychological distress predicts various detrimental consequences on social, behavioural, and cognitive development of the offspring and especially in girls. Maturation of white matter (WM) continues from prenatal development into adulthood and is thus…
Longitudinal consumption of fruits and vegetables and risk of asthma by 5 years of age
Pediatr Allergy Immunol. 2023 Mar;34(3):e13932. doi: 10.1111/pai.13932. ABSTRACT BACKGROUND: Fruit and vegetable consumption has been linked to a decreased risk of asthma, but prospective evidence on longitudinal consumption in childhood is scarce. We aimed to investigate the association between fruit and vegetable consumption in childhood and the risk of asthma…
