Hum Brain Mapp. 2023 May;44(7):2712-2725. doi: 10.1002/hbm.26238. Epub 2023 Mar 22. ABSTRACT The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and…
Publications
Publications
Stress-Related Exhaustion, Polygenic Cognitive Potential, and Cognitive Test Performance – A General Population Study
Cognit Ther Res. 2023;47(2):155-167. doi: 10.1007/s10608-023-10354-z. Epub 2023 Feb 4. ABSTRACT BACKGROUND: We investigated whether stress-related exhaustion (chronic or short-term, and co-occurring with depression or not) is related to cognitive performance and whether polygenic cognitive potential modifies these associations. METHODS: The participants were from the Young Finns Study (N =…
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study
BMJ Med. 2023 Feb 14;2(1):e000157. doi: 10.1136/bmjmed-2022-000157. eCollection 2023. ABSTRACT OBJECTIVE: To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. DESIGN: Bi-directional Mendelian randomisation study. SETTING: Genome-wide association studies from three Finnish cohorts (Northern Finland Birth…
Childhood Dyslipidemia and Carotid Atherosclerotic Plaque in Adulthood: The Cardiovascular Risk in Young Finns Study
J Am Heart Assoc. 2023 Apr 4;12(7):e027586. doi: 10.1161/JAHA.122.027586. Epub 2023 Mar 16. ABSTRACT Background Childhood exposure to dyslipidemia is associated with adult atherosclerosis, but it is unclear whether the long-term risk associated with dyslipidemia is attenuated on its resolution by adulthood. We aimed to address this question by examining…
Factors influencing vulnerability to climate change-related health impacts in cities – A conceptual framework
Environ Int. 2023 Mar;173:107837. doi: 10.1016/j.envint.2023.107837. Epub 2023 Feb 18. ABSTRACT Climate change will have adverse impacts on human health, which are amplified in cities. For these impacts, there are direct, indirect, and deferred pathways. The first category is well-studied, while indirect and deferred impacts are not well-understood. Moreover, the…
Pubertal development and hypogonadism in males with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a retrospective study
Eur J Endocrinol. 2023 Apr 4;188(4):K17-K23. doi: 10.1093/ejendo/lvad034. ABSTRACT The aim of this study was to describe the course of puberty and hypogonadism in males with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a Finnish APECED cohort followed up between 1970 and 2020. Anthropometry, testicular volumes and FSH, LH, and testosterone concentrations…
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Nat Genet. 2023 Mar;55(3):410-422. doi: 10.1038/s41588-023-01314-0. Epub 2023 Mar 13. ABSTRACT Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria…
OTTERS: a powerful TWAS framework leveraging summary-level reference data
Nat Commun. 2023 Mar 7;14(1):1271. doi: 10.1038/s41467-023-36862-w. ABSTRACT Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due…
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Diabetes Care. 2023 May 1;46(5):1014-1018. doi: 10.2337/dc22-1359. ABSTRACT OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study,…
Senior Health Clinic for 75-year-old home-dwelling Finns – study design, clinic protocol and non-response analysis
BMC Health Serv Res. 2023 Mar 2;23(1):210. doi: 10.1186/s12913-023-09199-9. ABSTRACT BACKGROUND: In the Finnish policy on older people preventive activities, which maintain functional capacity and independent living, are emphasized. The Turku Senior Health Clinic, aimed at maintaining independent coping of all home-dwelling 75-year-old citizens in the city of Turku, was…
