Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15-Year-Old Children Followed in the TEDDY Study

Diabetes Care. 2023 May 4:dc230036. doi: 10.2337/dc23-0036. Online ahead of print. ABSTRACT OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years. RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of…

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Gut microbiota composition and function in pregnancy as determinants of prediabetes at two-year postpartum

Acta Diabetol. 2023 Apr 28. doi: 10.1007/s00592-023-02064-5. Online ahead of print. ABSTRACT AIMS: Deep metagenomics offers an advanced tool for examining the relationship between gut microbiota composition and function and the onset of disease; in this case, does the composition and function of gut microbiota during pregnancy differ in women…

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Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts

Pediatr Allergy Immunol. 2023 Apr;34(4):e13945. doi: 10.1111/pai.13945. ABSTRACT BACKGROUND: Urban-related nature exposures are suggested to contribute to the rising prevalence of allergic diseases despite little supporting evidence. Our aim was to evaluate the impact of 12 land cover classes and two greenness indices around homes at birth on the development…

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Prenatal maternal depressive symptoms are associated with neonatal left amygdala microstructure in a sex-dependent way

Eur J Neurosci. 2023 May;57(10):1671-1688. doi: 10.1111/ejn.15989. Epub 2023 May 2. ABSTRACT Exposures to prenatal maternal depressive symptoms (PMDS) may lead to neurodevelopmental changes in the offspring in a sex-dependent way. Although a connection between PMDS and infant brain development has been established by earlier studies, the relationship between PMDS…

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Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system

Dev Psychopathol. 2023 Apr 3:1-16. doi: 10.1017/S0954579423000275. Online ahead of print. ABSTRACT Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap.

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Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis

Epigenetics. 2023 Dec;18(1):2211361. doi: 10.1080/15592294.2023.2211361. ABSTRACT BACKGROUND: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. METHODS: We meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association…

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Investigating the role of relationship satisfaction and paternal psychological distress during pregnancy on offspring health in early life

BJPsych Open. 2023 May 25;9(3):e100. doi: 10.1192/bjo.2023.59. ABSTRACT BACKGROUND: The research on the role of father in the foetal programming of health and behaviour has received increasing attention. However, the influences of paternal depressive symptoms and couple relationship satisfaction during pregnancy – potentially mediated via maternal well-being – on the…

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Modifications of 24-h movement behaviors to prevent obesity in retirement: a natural experiment using compositional data analysis

Int J Obes (Lond). 2023 May 23. doi: 10.1038/s41366-023-01326-0. Online ahead of print. ABSTRACT BACKGROUND: Retirement often leads to a more passive lifestyle and may therefore lead to weight gain. This study aims to investigate longitudinal associations between changes in 24-h movement behaviors and BMI and waist circumference in relation…

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