Publications

Circ Cardiovasc Qual Outcomes. 2025 Jul 24:e011873. doi: 10.1161/CIRCOUTCOMES.124.011873. Online ahead of print. ABSTRACT BACKGROUND: Sleep and physical activity (PA) are important lifestyle-related behaviors that impact cardiometabolic health. This study investigated the joint associations of daily step count and sleep patterns (regularity and duration) with cardiometabolic biomarkers in adults. METHODS:…

Nat Med. 2025 Jul 21. doi: 10.1038/s41591-025-03827-z. Online ahead of print. ABSTRACT Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European…

Atherosclerosis. 2025 Jul 12;408:120426. doi: 10.1016/j.atherosclerosis.2025.120426. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Population based data are limited on the prevalence of carotid atherosclerosis across broad age-ranges from early childhood to old age. We aimed to determine the prevalence and determinants of carotid artery plaques in a Finnish population.

medRxiv [Preprint]. 2025 Jul 8:2025.07.07.25331069. doi: 10.1101/2025.07.07.25331069. ABSTRACT BACKGROUND: Neighbourhood socioeconomic disadvantage is a known determinant of cardiovascular disease (CVD) risk. However, its impact on subclinical atherosclerosis across the life course remains inadequately understood. This study examined the association between cumulative neighbourhood socioeconomic disadvantage from childhood to midlife and carotid…

Eur J Epidemiol. 2025 Jul 12. doi: 10.1007/s10654-025-01270-5. Online ahead of print. ABSTRACT Faster nicotine metabolism, defined as the nicotine metabolite ratio (NMR), is known to associate with heavier smoking and challenges in smoking cessation. However, the broader health implications of genetically determined nicotine metabolism are not well characterized. We…

Lancet Healthy Longev. 2025 Jun;6(6):100717. doi: 10.1016/j.lanhl.2025.100717. ABSTRACT BACKGROUND: Blood-based biomarkers (BBM) of neurodegenerative diseases are emerging as cost-effective tools in the differential diagnostics of Alzheimer’s disease and other dementias. Scarce data exist about factors explaining BBM variation in population-based cohorts, and their intergenerational associations are unknown. This study aimed…

Acta Obstet Gynecol Scand. 2025 Jul 11. doi: 10.1111/aogs.70013. Online ahead of print. ABSTRACT INTRODUCTION: Sleep quality typically deteriorates during pregnancy, and poor sleep is a risk factor for pregnancy complications, including gestational diabetes mellitus (GDM). The present study is the first longitudinal study addressing associations between sleep quality and…

J Speech Lang Hear Res. 2025 Jul 10:1-17. doi: 10.1044/2025_JSLHR-24-00767. Online ahead of print. ABSTRACT PURPOSE: Research on early language development has primarily used two categories to group at-risk children, differing by the age at which risk is identified. Late talkers are toddlers with late onset of language development, some…

Soc Sci Med. 2025 Jun 27;382:118325. doi: 10.1016/j.socscimed.2025.118325. Online ahead of print. ABSTRACT BACKGROUND: Systematically high and upward mobile (lower childhood and higher adulthood) socioeconomic status (SES) has been suggested to be associated with better overall cognitive function in adulthood compared to systematically low or downward mobile (high childhood and…

Nat Commun. 2025 Jul 7;16(1):6254. doi: 10.1038/s41467-025-61463-0. ABSTRACT In eukaryotes, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, NXT1 has an X-chromosomal paralog, NXT2, which exhibits testis-enriched expression, suggesting a role in spermatogenesis. Here, we report the…