Publications

Mol Psychiatry. 2025 Sep 6. doi: 10.1038/s41380-025-03203-w. Online ahead of print. ABSTRACT Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual…

Eur Psychiatry. 2025 Sep 5:1-29. doi: 10.1192/j.eurpsy.2025.10097. Online ahead of print. NO ABSTRACT PMID:40908266 | DOI:10.1192/j.eurpsy.2025.10097…

J Phys Act Health. 2025 Aug 19:1-9. doi: 10.1123/jpah.2024-0644. Online ahead of print. ABSTRACT BACKGROUND: This paper aims to examine and compare the levels and changes in physical activity (PA) and weight status over an 11-year follow-up among adults with varying commuting modes to work. METHODS: Overall, 1357 Finnish adults…

Eur J Ageing. 2025 Aug 7;22(1):40. doi: 10.1007/s10433-025-00876-8. ABSTRACT The transition to retirement has been shown to be accompanied by increased sleep duration and improved sleep quality. In addition, some studies suggest accelerated decline in cognitive function in post-retirement years. However, less is known about their interconnectedness. The aim of…

Circ Cardiovasc Qual Outcomes. 2025 Jul 24:e011873. doi: 10.1161/CIRCOUTCOMES.124.011873. Online ahead of print. ABSTRACT BACKGROUND: Sleep and physical activity (PA) are important lifestyle-related behaviors that impact cardiometabolic health. This study investigated the joint associations of daily step count and sleep patterns (regularity and duration) with cardiometabolic biomarkers in adults. METHODS:…

Nat Med. 2025 Jul 21. doi: 10.1038/s41591-025-03827-z. Online ahead of print. ABSTRACT Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European…

Atherosclerosis. 2025 Jul 12;408:120426. doi: 10.1016/j.atherosclerosis.2025.120426. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Population based data are limited on the prevalence of carotid atherosclerosis across broad age-ranges from early childhood to old age. We aimed to determine the prevalence and determinants of carotid artery plaques in a Finnish population.

medRxiv [Preprint]. 2025 Jul 8:2025.07.07.25331069. doi: 10.1101/2025.07.07.25331069. ABSTRACT BACKGROUND: Neighbourhood socioeconomic disadvantage is a known determinant of cardiovascular disease (CVD) risk. However, its impact on subclinical atherosclerosis across the life course remains inadequately understood. This study examined the association between cumulative neighbourhood socioeconomic disadvantage from childhood to midlife and carotid…

Eur J Epidemiol. 2025 Jul 12. doi: 10.1007/s10654-025-01270-5. Online ahead of print. ABSTRACT Faster nicotine metabolism, defined as the nicotine metabolite ratio (NMR), is known to associate with heavier smoking and challenges in smoking cessation. However, the broader health implications of genetically determined nicotine metabolism are not well characterized. We…

Lancet Healthy Longev. 2025 Jun;6(6):100717. doi: 10.1016/j.lanhl.2025.100717. ABSTRACT BACKGROUND: Blood-based biomarkers (BBM) of neurodegenerative diseases are emerging as cost-effective tools in the differential diagnostics of Alzheimer’s disease and other dementias. Scarce data exist about factors explaining BBM variation in population-based cohorts, and their intergenerational associations are unknown. This study aimed…