Br J Nutr. 2023 Feb 21:1-11. doi: 10.1017/S0007114523000466. Online ahead of print. ABSTRACT The current definition of dietary fibre was adopted by the Codex Alimentarius Commission in 2009, but implementation requires updating food composition databases with values based on appropriate analysis methods. Previous data on population intakes of dietary fibre…
Author: Henok Karvonen
HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine
J Med Virol. 2023 Apr;95(4):e28707. doi: 10.1002/jmv.28707. ABSTRACT This study investigated whether children with HLA-DQ-conferred risk for type 1 diabetes (T1D) have an altered immune response to the widely-used enterovirus vaccine, namely poliovirus vaccine, and whether initiation of autoimmunity to pancreatic islets modulates this response. Neutralizing antibodies induced by the…
Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum
Metabolomics. 2023 Mar 24;19(4):20. doi: 10.1007/s11306-023-01994-z. ABSTRACT INTRODUCTION: Aberrations in circulating metabolites have been associated with diabetes and cardiovascular risk. OBJECTIVES: To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic. METHODS: An NMR…
Sex differences, asymmetry, and age-related white matter development in infants and 5-year-olds as assessed with tract-based spatial statistics
Hum Brain Mapp. 2023 May;44(7):2712-2725. doi: 10.1002/hbm.26238. Epub 2023 Mar 22. ABSTRACT The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and…
The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study
Front Psychiatry. 2023 Apr 18;14:1018797. doi: 10.3389/fpsyt.2023.1018797. eCollection 2023. ABSTRACT INTRODUCTION: Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current…
Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes
J Intern Med. 2023 May 4. doi: 10.1111/joim.13648. Online ahead of print. ABSTRACT The etiology of type 1 diabetes (T1D) foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of T1D. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A),…
Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15-Year-Old Children Followed in the TEDDY Study
Diabetes Care. 2023 May 4:dc230036. doi: 10.2337/dc23-0036. Online ahead of print. ABSTRACT OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years. RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of…
Gut microbiota composition and function in pregnancy as determinants of prediabetes at two-year postpartum
Acta Diabetol. 2023 Apr 28. doi: 10.1007/s00592-023-02064-5. Online ahead of print. ABSTRACT AIMS: Deep metagenomics offers an advanced tool for examining the relationship between gut microbiota composition and function and the onset of disease; in this case, does the composition and function of gut microbiota during pregnancy differ in women…
Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts
Pediatr Allergy Immunol. 2023 Apr;34(4):e13945. doi: 10.1111/pai.13945. ABSTRACT BACKGROUND: Urban-related nature exposures are suggested to contribute to the rising prevalence of allergic diseases despite little supporting evidence. Our aim was to evaluate the impact of 12 land cover classes and two greenness indices around homes at birth on the development…
Spillover effects of the COVID-19 pandemic on attitudes to influenza and childhood vaccines
BMC Public Health. 2023 Apr 25;23(1):764. doi: 10.1186/s12889-023-15653-4. ABSTRACT The current study sought to determine whether public perceptions of other vaccines and diseases than COVID-19 have been impacted by the COVID-19 pandemic. We longitudinally examined whether there had been a change from before the COVID-19 pandemic to during the pandemic…
