Eur J Immunol. 2025 Jun;55(6):e51704. doi: 10.1002/eji.202451704. ABSTRACT Circulating follicular (cTfh) and peripheral (cTph) T helper cells have been demonstrated to be expanded in several autoimmune diseases, including type 1 diabetes (T1D). Here, we examined the frequencies and phenotypes of these cells at different stages of T1D development and addressed…
Author: Henok Karvonen
Changes in life satisfaction and leisure-time physical activity across retirement transition: the FIREA cohort study
Eur J Ageing. 2025 Jun 17;22(1):29. doi: 10.1007/s10433-025-00865-x. ABSTRACT Retirement brings changes in daily life, which may have implications for life satisfaction and leisure-time physical activity (LTPA). This study sought to examine associations between concurrent changes in life satisfaction and LTPA across retirement, addressing gaps in understanding how life satisfaction…
β-Cell Function and Glucose Tolerance in Persons With Multiple Islet Autoantibodies Randomized to a Gluten-free Diet
J Endocr Soc. 2025 May 7;9(8):bvaf073. doi: 10.1210/jendso/bvaf073. eCollection 2025 Aug. ABSTRACT PURPOSE: A randomized clinical trial was conducted to evaluate the impact of a gluten-free diet (GFD) on β-cell function and glucose tolerance in persons with multiple islet autoantibodies. METHODS: Individuals (n = 59; median age 11 years) with…
Gestational diabetes mellitus and children’s social-emotional development, behavioral problems, and psychological adjustment
Pediatr Res. 2025 Jun 10. doi: 10.1038/s41390-025-04191-x. Online ahead of print. ABSTRACT BACKGROUND: This longitudinal cohort study investigated whether gestational diabetes mellitus (GDM) is associated with 2- and 5-year-old children’s social-emotional development and whether child sex moderates the association. METHODS: FinnBrain Birth Cohort Study recruited 3808 pregnant women 2011-2015 in…
Maternal diet and gestational diabetes mellitus modestly influence children’s growth during their first 24 months
J Pediatr Gastroenterol Nutr. 2025 Jun 9. doi: 10.1002/jpn3.70098. Online ahead of print. ABSTRACT OBJECTIVE: To evaluate whether diet and gestational diabetes mellitus (GDM) during pregnancy influence children’s growth during their first 24 months. METHODS: Growth data of children (n = 378) of women with overweight/obesity were obtained from clinic…
Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate
Mol Med. 2025 Jun 9;31(1):224. doi: 10.1186/s10020-025-01292-5. NO ABSTRACT PMID:40490708 | DOI:10.1186/s10020-025-01292-5…
Associations of Leukocyte Telomere Length With Trait Resilience, Adverse Childhood Experiences, and Psychological Distress Among Expecting Parents in the FinnBrain Birth Cohort
Biol Psychiatry Glob Open Sci. 2025 Apr 1;5(4):100498. doi: 10.1016/j.bpsgos.2025.100498. eCollection 2025 Jul. ABSTRACT BACKGROUND: Telomere attrition has previously been associated with mental health problems and adverse childhood experiences (ACEs). Resilience has been shown to protect against mental health problems even in the context of ACEs. In this study, we…
Longitudinal study of factors predicting toothbrushing less than twice daily at age 2 years in the FinnBrain Birth Cohort Study
Eur J Oral Sci. 2025 Jun 9:e70024. doi: 10.1111/eos.70024. Online ahead of print. ABSTRACT We aimed to identify factors predicting toothbrushing less than twice daily at the age of 2 years. The data from the FinnBrain Birth Cohort Study of 506 mother-father pairs (with 506 children) were used. Logistic regression…
Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality
bioRxiv [Preprint]. 2025 May 19:2025.05.16.648988. doi: 10.1101/2025.05.16.648988. ABSTRACT Personality traits describe stable differences in how individuals think, feel, and behave and how they interact with and experience their social and physical environments. We assemble data from 46 cohorts including 611K-1.14M participants with European-like and African-like genomes for genome-wide association studies…
Effect of gestational anemia on breastfeeding- a prospective follow-up -study
BMC Pregnancy Childbirth. 2025 Jun 4;25(1):653. doi: 10.1186/s12884-025-07775-x. ABSTRACT BACKGROUND: Gestational anemia is a common pregnancy complication that affects approximately 40% of pregnant women globally. The health benefits of breastfeeding are widely acknowledged for both mothers and infants, and recognizing the factors that affect the duration and quality (exclusive /…
