Eur J Ageing. 2022 Dec;19(4):1301-1310. doi: 10.1007/s10433-022-00714-1. Epub 2022 Jun 22. ABSTRACT BACKGROUND: With advancing age, physical capacity gradually decreases which may lead to decreased work ability, if the physical work requirements remain the same. Examination of the importance of physical fitness for work ability among aging workers will help…
Author: Henok Karvonen
Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study
Lancet Child Adolesc Health. 2023 Apr;7(4):261-268. doi: 10.1016/S2352-4642(22)00350-9. Epub 2023 Jan 18. ABSTRACT BACKGROUND: Screening for islet autoantibodies in children and adolescents identifies individuals who will later develop type 1 diabetes, allowing patient and family education to prevent diabetic ketoacidosis at onset and to enable consideration of preventive therapies. We…
Cross-sectionally calculated metabolic ageing does not relate to longitudinal metabolic changes – support for stratified ageing models
J Clin Endocrinol Metab. 2023 Jan 20:dgad032. doi: 10.1210/clinem/dgad032. Online ahead of print. ABSTRACT CONTEXT: Ageing varies between individuals with profound consequences for chronic diseases and longevity. One hypothesis to explain the diversity is a genetically regulated molecular clock that runs differently between individuals. Large and long enough human studies…
Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study
BMC Med. 2023 Jan 18;21(1):23. doi: 10.1186/s12916-022-02711-8. ABSTRACT BACKGROUND: Common pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in the offspring and these associations might differ with offspring age. METHODS: We used data from eight population-based cohort studies to examine…
Intake and sources of dietary fibre and dietary fibre fractions in Finnish children
Br J Nutr. 2023 Feb 21:1-11. doi: 10.1017/S0007114523000466. Online ahead of print. ABSTRACT The current definition of dietary fibre was adopted by the Codex Alimentarius Commission in 2009, but implementation requires updating food composition databases with values based on appropriate analysis methods. Previous data on population intakes of dietary fibre…
HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine
J Med Virol. 2023 Apr;95(4):e28707. doi: 10.1002/jmv.28707. ABSTRACT This study investigated whether children with HLA-DQ-conferred risk for type 1 diabetes (T1D) have an altered immune response to the widely-used enterovirus vaccine, namely poliovirus vaccine, and whether initiation of autoimmunity to pancreatic islets modulates this response. Neutralizing antibodies induced by the…
Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum
Metabolomics. 2023 Mar 24;19(4):20. doi: 10.1007/s11306-023-01994-z. ABSTRACT INTRODUCTION: Aberrations in circulating metabolites have been associated with diabetes and cardiovascular risk. OBJECTIVES: To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic. METHODS: An NMR…
Sex differences, asymmetry, and age-related white matter development in infants and 5-year-olds as assessed with tract-based spatial statistics
Hum Brain Mapp. 2023 May;44(7):2712-2725. doi: 10.1002/hbm.26238. Epub 2023 Mar 22. ABSTRACT The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and…
Stress-Related Exhaustion, Polygenic Cognitive Potential, and Cognitive Test Performance – A General Population Study
Cognit Ther Res. 2023;47(2):155-167. doi: 10.1007/s10608-023-10354-z. Epub 2023 Feb 4. ABSTRACT BACKGROUND: We investigated whether stress-related exhaustion (chronic or short-term, and co-occurring with depression or not) is related to cognitive performance and whether polygenic cognitive potential modifies these associations. METHODS: The participants were from the Young Finns Study (N =…
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study
BMJ Med. 2023 Feb 14;2(1):e000157. doi: 10.1136/bmjmed-2022-000157. eCollection 2023. ABSTRACT OBJECTIVE: To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. DESIGN: Bi-directional Mendelian randomisation study. SETTING: Genome-wide association studies from three Finnish cohorts (Northern Finland Birth…
