Diabetes Care. 2023 Mar 2:dc221960. doi: 10.2337/dc22-1960. Online ahead of print. ABSTRACT OBJECTIVE: To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS: Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set…

Int J Obes (Lond). 2023 Jun;47(6):453-462. doi: 10.1038/s41366-023-01281-w. Epub 2023 Feb 23. ABSTRACT BACKGROUND/OBJECTIVE: This observational study dissects the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR) and circulating metabolomics using a combination of longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. SUBJECTS/METHODS: Firstly, a data-driven…

Sci Rep. 2023 Feb 22;13(1):3078. doi: 10.1038/s41598-023-30168-z. ABSTRACT Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and plasma lipidome (phenotype) in order to identify the genetic architecture of…

Br J Nutr. 2023 Feb 21:1-11. doi: 10.1017/S0007114523000466. Online ahead of print. ABSTRACT The current definition of dietary fibre was adopted by the Codex Alimentarius Commission in 2009, but implementation requires updating food composition databases with values based on appropriate analysis methods. Previous data on population intakes of dietary fibre…

J Med Virol. 2023 Apr;95(4):e28707. doi: 10.1002/jmv.28707. ABSTRACT This study investigated whether children with HLA-DQ-conferred risk for type 1 diabetes (T1D) have an altered immune response to the widely-used enterovirus vaccine, namely poliovirus vaccine, and whether initiation of autoimmunity to pancreatic islets modulates this response. Neutralizing antibodies induced by the…

Metabolomics. 2023 Mar 24;19(4):20. doi: 10.1007/s11306-023-01994-z. ABSTRACT INTRODUCTION: Aberrations in circulating metabolites have been associated with diabetes and cardiovascular risk. OBJECTIVES: To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic. METHODS: An NMR…

Hum Brain Mapp. 2023 May;44(7):2712-2725. doi: 10.1002/hbm.26238. Epub 2023 Mar 22. ABSTRACT The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and…

Cognit Ther Res. 2023;47(2):155-167. doi: 10.1007/s10608-023-10354-z. Epub 2023 Feb 4. ABSTRACT BACKGROUND: We investigated whether stress-related exhaustion (chronic or short-term, and co-occurring with depression or not) is related to cognitive performance and whether polygenic cognitive potential modifies these associations. METHODS: The participants were from the Young Finns Study (N =…

BMJ Med. 2023 Feb 14;2(1):e000157. doi: 10.1136/bmjmed-2022-000157. eCollection 2023. ABSTRACT OBJECTIVE: To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. DESIGN: Bi-directional Mendelian randomisation study. SETTING: Genome-wide association studies from three Finnish cohorts (Northern Finland Birth…

J Am Heart Assoc. 2023 Apr 4;12(7):e027586. doi: 10.1161/JAHA.122.027586. Epub 2023 Mar 16. ABSTRACT Background Childhood exposure to dyslipidemia is associated with adult atherosclerosis, but it is unclear whether the long-term risk associated with dyslipidemia is attenuated on its resolution by adulthood. We aimed to address this question by examining…