Schizophrenia (Heidelb). 2022 Oct 11;8(1):82. doi: 10.1038/s41537-022-00282-4. ABSTRACT Abnormal glucose and lipid metabolism is common in antipsychotic-naive first-episode patients with schizophrenia, but it is unclear whether these changes can already be seen in premorbid or prodromal period, before the first psychotic episode. We examined insulin, total cholesterol, low-density lipoprotein (LDL)…
Publications
Publications
Parenthood and changes in physical activity from early adulthood to mid-life among Finnish adults
Scand J Med Sci Sports. 2023 May;33(5):682-692. doi: 10.1111/sms.14293. Epub 2023 Jan 4. ABSTRACT This study examined longitudinal associations between parenthood-related factors and physical activity from young adulthood to midlife over a 19-year follow-up period. Participants (n = 761) at the ongoing Cardiovascular Risk in Young Finns Study responded to…
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genome Biol. 2022 Dec 27;23(1):268. doi: 10.1186/s13059-022-02837-1. ABSTRACT BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.
Prenatal exposure to phenols and benzophenones in relation to markers of male reproductive function in adulthood
Front Endocrinol (Lausanne). 2022 Dec 9;13:1071761. doi: 10.3389/fendo.2022.1071761. eCollection 2022. ABSTRACT INTRODUCTION: Environmental exposure during fetal life may disrupt testicular development. In humans, a limited number of studies have investigated whether these adverse effects persist into adulthood. Using data from a prospective, population-based birth cohort study, The Copenhagen Mother-Child cohort,…
Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutation in Patients with Acute Alcohol Pancreatitis (AAP) Compared to Healthy Controls and Heavy Alcohol Users without Pancreatitis
Int J Mol Sci. 2022 Dec 11;23(24):15726. doi: 10.3390/ijms232415726. ABSTRACT Only 3-5% of heavy alcohol users develop acute alcohol pancreatitis (AAP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AAP, and SPINK1 mutation is a documented risk factor. We…
Unpredictable maternal sensory signals in caregiving behavior are associated with child effortful control
PLoS One. 2022 Dec 20;17(12):e0279384. doi: 10.1371/journal.pone.0279384. eCollection 2022. ABSTRACT Emerging evidence suggests that exposure to unpredictable patterns of maternal sensory signals during infancy is associated with child neurodevelopment, including poorer effortful control. However, longitudinal effects on child development and possible sex differences are understudied. The aims of the present…
Health-related quality of life in boys with constitutional delay of growth and puberty
Front Endocrinol (Lausanne). 2022 Nov 25;13:1028828. doi: 10.3389/fendo.2022.1028828. eCollection 2022. ABSTRACT INTRODUCTION: Constitutional delay of growth and puberty (CDGP) is the most common reason for delayed puberty in healthy male adolescents. The main indication for medical treatment for this condition is psychosocial burden. However, to the best of our knowledge,…
Work ability and physical fitness among aging workers: the Finnish Retirement and Aging Study
Eur J Ageing. 2022 Jun 22;19(4):1301-1310. doi: 10.1007/s10433-022-00714-1. eCollection 2022 Dec. ABSTRACT BACKGROUND: With advancing age, physical capacity gradually decreases which may lead to decreased work ability, if the physical work requirements remain the same. Examination of the importance of physical fitness for work ability among aging workers will help…
Changes in life satisfaction during the transition to retirement: findings from the FIREA cohort study
Eur J Ageing. 2022 Nov 23;19(4):1587-1599. doi: 10.1007/s10433-022-00745-8. eCollection 2022 Dec. ABSTRACT Life satisfaction is an essential construct of well-being that is tied to behavioral, emotional, social and psychological outcomes. This study aimed to examine changes in total and domain-specific life satisfaction during the retirement transition and additionally examine whether…
Meanings Attributed to Physical Activity and Changes in Self-Reported and Accelerometer-Measured Physical Activity among Recent Retirees
Int J Environ Res Public Health. 2022 Nov 23;19(23):15567. doi: 10.3390/ijerph192315567. ABSTRACT Retirement poses opportunities and challenges for maintaining and adopting physically active habits, which may have major implications for health and functional ability in later life. Qualitative studies suggest that a broad range of meanings of physical activity should…
