Soc Sci Med. 2025 Jun 27;382:118325. doi: 10.1016/j.socscimed.2025.118325. Online ahead of print. ABSTRACT BACKGROUND: Systematically high and upward mobile (lower childhood and higher adulthood) socioeconomic status (SES) has been suggested to be associated with better overall cognitive function in adulthood compared to systematically low or downward mobile (high childhood and…
Publications
Publications
NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis
Nat Commun. 2025 Jul 7;16(1):6254. doi: 10.1038/s41467-025-61463-0. ABSTRACT In eukaryotes, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, NXT1 has an X-chromosomal paralog, NXT2, which exhibits testis-enriched expression, suggesting a role in spermatogenesis. Here, we report the…
Concurrent Changes in 24-Hour Movement Behaviors and Cognitive Function during Retirement Transition: Longitudinal Compositional Data Analysis
Med Sci Sports Exerc. 2025 Jul 4. doi: 10.1249/MSS.0000000000003801. Online ahead of print. ABSTRACT BACKGROUND: Transitioning to retirement may change physical activity, sedentary behavior, and sleep, i.e., 24-h movement behaviors, but it is unknown whether these changes are linked to cognitive function. This study investigates the longitudinal associations between changes…
Paternal adverse childhood experiences and offspring’s attentional disengagement from faces at 8 months-Results from the FinnBrain Birth Cohort Study
PLoS One. 2025 Jul 3;20(7):e0326437. doi: 10.1371/journal.pone.0326437. eCollection 2025. ABSTRACT Paternal adverse childhood experiences (ACEs) have been recently linked to offspring’s brain development. Yet, none of the previous studies in humans have explored the association between paternal ACEs and a child’s attentional bias for facial expressions of emotion. Our study…
Does accelerometer-measured physical activity and sedentary time differ between manual, in-office, hybrid and remote workers?
Occup Environ Med. 2025 Jun 25:oemed-2025-110105. doi: 10.1136/oemed-2025-110105. Online ahead of print. ABSTRACT OBJECTIVES: Studies on accelerometer-measured daily physical activity behaviour, especially among hybrid and remote workers, are scarce. We compared daily occupational and non-occupational physical activity and sedentary time among manual, in-office, hybrid and remote workers. In addition, physical…
Maternal and umbilical cord serum lipids in gestational diabetes predict offspring insulin secretion and resistance at the age of nine years
Metabolomics. 2025 Jun 22;21(4):87. doi: 10.1007/s11306-025-02281-9. ABSTRACT INTRODUCTION: Maternal metabolism in pregnancy is a major determinant of intrauterine milieu and is assumed to have long-term consequences in the offspring. OBJECTIVES: To study whether maternal or cord serum lipids are related to measures of insulin resistance and β-cell function in childhood.
The Frequency but not the Phenotype of Circulating Peripheral T Helper Cells is Increased at Later Stages of Progression to Type 1 Diabetes
Eur J Immunol. 2025 Jun;55(6):e51704. doi: 10.1002/eji.202451704. ABSTRACT Circulating follicular (cTfh) and peripheral (cTph) T helper cells have been demonstrated to be expanded in several autoimmune diseases, including type 1 diabetes (T1D). Here, we examined the frequencies and phenotypes of these cells at different stages of T1D development and addressed…
Changes in life satisfaction and leisure-time physical activity across retirement transition: the FIREA cohort study
Eur J Ageing. 2025 Jun 17;22(1):29. doi: 10.1007/s10433-025-00865-x. ABSTRACT Retirement brings changes in daily life, which may have implications for life satisfaction and leisure-time physical activity (LTPA). This study sought to examine associations between concurrent changes in life satisfaction and LTPA across retirement, addressing gaps in understanding how life satisfaction…
β-Cell Function and Glucose Tolerance in Persons With Multiple Islet Autoantibodies Randomized to a Gluten-free Diet
J Endocr Soc. 2025 May 7;9(8):bvaf073. doi: 10.1210/jendso/bvaf073. eCollection 2025 Aug. ABSTRACT PURPOSE: A randomized clinical trial was conducted to evaluate the impact of a gluten-free diet (GFD) on β-cell function and glucose tolerance in persons with multiple islet autoantibodies. METHODS: Individuals (n = 59; median age 11 years) with…
Gestational diabetes mellitus and children’s social-emotional development, behavioral problems, and psychological adjustment
Pediatr Res. 2025 Jun 10. doi: 10.1038/s41390-025-04191-x. Online ahead of print. ABSTRACT BACKGROUND: This longitudinal cohort study investigated whether gestational diabetes mellitus (GDM) is associated with 2- and 5-year-old children’s social-emotional development and whether child sex moderates the association. METHODS: FinnBrain Birth Cohort Study recruited 3808 pregnant women 2011-2015 in…
