Publications

Nat Commun. 2024 Jan 18;15(1):586. doi: 10.1038/s41467-024-44709-1. ABSTRACT X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the…

Genome Biol. 2024 Jan 16;25(1):22. doi: 10.1186/s13059-023-03136-z. ABSTRACT BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated…

J Nutr. 2024 Jan 12:S0022-3166(24)00027-0. doi: 10.1016/j.tjnut.2024.01.008. Online ahead of print. ABSTRACT BACKGROUND: Dietary fiber is an important health-promoting component of the diet, which is fermented by the gut microbes that produce metabolites beneficial for the host’s health. OBJECTIVE: We studied the associations of habitual long-term fiber intake from infancy…

J Affect Disord. 2024 Jan 11:S0165-0327(24)00103-4. doi: 10.1016/j.jad.2024.01.093. Online ahead of print. ABSTRACT BACKGROUND: A great number of case-control and population-based studies have shown that depression patients differ from healthy controls in their temperament traits. We investigated whether polygenic risk for depression predicts trajectories of temperament traits from early adulthood…

J Affect Disord. 2024 Jan 4:S0165-0327(23)01544-6. doi: 10.1016/j.jad.2023.12.076. Online ahead of print. ABSTRACT Maternal symptoms of depression and anxiety during pregnancy and early postnatal years are suggested to impose differential negative effects on child’s socio-emotional development depending on the characteristics of the symptoms, such as timing, intensity, and persistence. The…

Environ Health Perspect. 2023 Dec;131(12):127020. doi: 10.1289/EHP12080. Epub 2023 Dec 27. ABSTRACT BACKGROUND: Climate change scenarios illustrate various pathways in terms of global warming ranging from “sustainable development” (Shared Socioeconomic Pathway SSP1-1.9), the best-case scenario, to ‘fossil-fueled development’ (SSP5-8.5), the worst-case scenario. OBJECTIVES: We examined the extent to which increase…

Am J Clin Nutr. 2023 Dec 22:S0002-9165(23)66347-6. doi: 10.1016/j.ajcnut.2023.12.014. Online ahead of print. ABSTRACT BACKGROUND: Prospective studies investigating the association between fruit, berry, and vegetable consumption and the risk of islet autoimmunity (IA) and type 1 diabetes (T1D) are few. OBJECTIVE: In this cohort study, we explored whether the consumption…

Int J Cardiol Cardiovasc Risk Prev. 2023 Dec 8;20:200227. doi: 10.1016/j.ijcrp.2023.200227. eCollection 2024 Mar. ABSTRACT To investigate the association of number of siblings with preclinical cardiovascular disease (CVD) markers in adulthood. The sample comprised 2776 participants (54 % female) from the Cardiovascular Risk in Young Finns Study who had CVD…

BMJ Open. 2023 Dec 10;13(12):e076976. doi: 10.1136/bmjopen-2023-076976. ABSTRACT PURPOSE: The Finnish Retirement and Aging (FIREA) Study was set up to study changes in health behavioural and cardiometabolic risk factors across retirement transition, and to examine the long-term consequences of work and retirement on health and functioning with advancing age. PARTICIPANTS:…

Sex Reprod Healthc. 2023 Nov 24;39:100930. doi: 10.1016/j.srhc.2023.100930. Online ahead of print. ABSTRACT OBJECTIVE: Expecting mothers with high sense of coherence (SOC) exhibit improved physical, emotional, and childbearing health. However, the dimensions of SOC and the factor structure of the SOC-13 scale during prenatal period is slightly known. Especially the…