Nat Commun. 2023 Aug 2;14(1):4646. doi: 10.1038/s41467-023-39521-2. ABSTRACT Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate…
Publications
Publications
SARS-CoV-2 – No Increased Islet Autoimmunity or Type 1 Diabetes in Teens
N Engl J Med. 2023 Aug 3;389(5):474-475. doi: 10.1056/NEJMc2216477. NO ABSTRACT PMID:37530831 | DOI:10.1056/NEJMc2216477…
Polygenic liabilities underlying job stress and exhaustion over a 10-year follow-up: A general population study
Psychiatry Res. 2023 Jul 17;326:115355. doi: 10.1016/j.psychres.2023.115355. Online ahead of print. ABSTRACT We investigated whether individuals, who have a high polygenic loading for schizophrenia and major depression (PGL) but have not developed the respective disorders, are still susceptible to experience milder forms of ill-being in terms of job strain or…
Non-alcoholic fatty liver disease incidence and remission and their predictors during 7 years follow-up among Finns
J Clin Endocrinol Metab. 2023 Jul 18:dgad418. doi: 10.1210/clinem/dgad418. Online ahead of print. ABSTRACT BACKGROUND & AIMS: The incidence and remission of non-alcoholic fatty liver disease (NAFLD) are sparsely studied outside Asia. This prospective study aimed to investigate NAFLD incidence and remission, and their predictors among a general Finnish population.
Trajectories of cardiovascular risk predict pregnancy outcomes: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study
Paediatr Perinat Epidemiol. 2023 Jul 11. doi: 10.1111/ppe.12995. Online ahead of print. ABSTRACT BACKGROUND: Life course patterns of change in risk-trajectories-affect health. OBJECTIVES: To examine how trajectories of cardiovascular risk factors are associated with pregnancy and birth outcomes. METHODS: Data from two cohort studies participating in the International Childhood Cardiovascular…
Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression
Front Immunol. 2023 Jun 21;14:1157265. doi: 10.3389/fimmu.2023.1157265. eCollection 2023. ABSTRACT IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. We measured…
Plasma calprotectin is extremely high in patients with lysinuric protein intolerance
JIMD Rep. 2023 Jun 20;64(4):293-299. doi: 10.1002/jmd2.12377. eCollection 2023 Jul. ABSTRACT Lysinuric protein intolerance (LPI) is a rare autosomal recessive disorder affecting the transport of cationic amino acids. Elevated plasma zinc concentrations have been described in patients with LPI. Calprotectin is a calcium- and zinc-binding protein, produced by polymorphonuclear leukocytes…
Childhood family environment predicting psychotic disorders over a 37-year follow-up – A general population cohort study
Schizophr Res. 2023 Jun 29;258:9-17. doi: 10.1016/j.schres.2023.06.008. Online ahead of print. ABSTRACT BACKGROUND: Childhood adverse effects and traumatic experiences increase the risk for several psychiatric disorders. We now investigated whether prospectively assessed childhood family environment per se contributes to increased risk for psychotic disorders in adulthood, and whether these family…
Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
Cell Rep Med. 2023 Jun 23:101093. doi: 10.1016/j.xcrm.2023.101093. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study…
Associations of breastfeeding duration with serum lipid values from infancy until age 20 years – the STRIP study
Scand J Public Health. 2023 Jun 30:14034948231183030. doi: 10.1177/14034948231183030. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: The effect of breastfeeding duration on childhood lipid levels has remained controversial. In this study, we aimed to establish the long-term associations of breastfeeding duration with future levels of total cholesterol, high-density lipoprotein…
