Commun Med (Lond). 2023 Jan 18;3(1):4. doi: 10.1038/s43856-022-00226-0. ABSTRACT BACKGROUND: Testosterone levels are linked with diverse characteristics of human health, yet, whether these associations reflect correlation or causation remains debated. Here, we provide a broad perspective on the role of genetically determined testosterone on complex diseases in both sexes. METHODS:…
Publications
Publications
Inflammatory biomarkers after an exercise intervention in childhood acute lymphoblastic leukemia survivors
EJHaem. 2022 Sep 29;3(4):1188-1200. doi: 10.1002/jha2.588. eCollection 2022 Nov. ABSTRACT Cancer survivors show increased risk for non-communicable diseases and chronic low-grade inflammation characterizes the development of such diseases. We investigated inflammatory plasma protein profiles of survivors of childhood acute lymphoblastic leukemia (ALL) in comparison to healthy controls and after an…
Course of child social-emotional and sleep symptoms, parental distress and pandemic-related stressors during COVID-19
Dev Psychopathol. 2023 Feb 16:1-15. doi: 10.1017/S0954579422001377. Online ahead of print. ABSTRACT Research on the longitudinal courses of child social-emotional symptoms and sleep during the COVID-19 pandemic within societies would be of key value for promoting child well-being in global crises. We characterized the course of children’s social-emotional and sleep…
Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study
BMC Med. 2023 Feb 14;21(1):57. doi: 10.1186/s12916-023-02743-8. ABSTRACT BACKGROUND: An extensive body of animal literature supports the premise that maternal obesity during pregnancy can alter the development of the fetal hypothalamus (HTH, a critical regulator of energy balance) with implications for offspring obesity risk (i.e., long-term energy imbalance). Yet, the…
A new blood based epigenetic age predictor for adolescents and young adults
Sci Rep. 2023 Feb 9;13(1):2303. doi: 10.1038/s41598-023-29381-7. ABSTRACT Children have special rights for protection compared to adults in our society. However, more than 1/4 of children globally have no documentation of their date of birth. Hence, there is a pressing need to develop biological methods for chronological age prediction, robust…
Relationships between alexithymia and food addiction: The Finnish version of Yale Food Addiction Scale and preliminary test of its psychometric properties
Front Psychol. 2023 Jan 19;14:1067872. doi: 10.3389/fpsyg.2023.1067872. eCollection 2023. ABSTRACT BACKGROUND: It has long been suggested that addictive behaviors are associated with alexithymia, a personality trait characterized by difficulties in emotional awareness and expression. However, little is known about the role of alexithymia in food addiction. OBJECTIVES: The aim of…
Maternal phthalate exposure during pregnancy and testis function of young adult sons
Sci Total Environ. 2023 May 1;871:161914. doi: 10.1016/j.scitotenv.2023.161914. Epub 2023 Jan 31. ABSTRACT BACKGROUND: Phthalate exposure during fetal life may disrupt testicular development. Congruent with this, studies have found shorter anogenital distance, reduced penile size and altered hormone levels in infant boys whose mothers were exposed to higher levels of…
Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study
PLoS One. 2023 Feb 2;18(2):e0275123. doi: 10.1371/journal.pone.0275123. eCollection 2023. ABSTRACT BACKGROUND: Celiac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, determine adherence-related factors, and compare adherence to food…
Daily Physical Activity Patterns and Their Associations with Cardiometabolic Biomarkers: The Maastricht Study
Med Sci Sports Exerc. 2023 May 1;55(5):837-846. doi: 10.1249/MSS.0000000000003108. Epub 2022 Dec 27. ABSTRACT PURPOSE: This study aimed to identify physical activity patterns and examine their association with cardiometabolic biomarkers in a cross-sectional design. METHODS: Overall 6072 participants (mean age, 60.2 yr; SD 8.6 yr, 50% women) from The Maastricht…
Probable Sarcopenia, Obesity, and Risk of All-Cause Mortality: A Pooled Analysis of 4,612 Participants
Gerontology. 2023;69(6):706-715. doi: 10.1159/000527804. Epub 2023 Jan 30. ABSTRACT INTRODUCTION: Conflicting evidence exists concerning whether having sarcopenic obesity has additive mortality risk over having only sarcopenia or obesity. We examined the independent and combined associations of obesity and probable sarcopenia with all-cause mortality. METHODS: The pooled analysis included three large,…
