Dis Model Mech. 2022 Oct 1;15(10):dmm049490. doi: 10.1242/dmm.049490. Epub 2022 Oct 26. ABSTRACT Isolated populations have been valuable for the discovery of rare monogenic diseases and their causative genetic variants. Finnish disease heritage (FDH) is an example of a group of hereditary monogenic disorders caused by single major, usually autosomal-recessive,…
Publications
Publications
Influencing adolescents’ attitudes towards nicotine products: A systematic review
Nordisk Alkohol Nark. 2022 Oct;39(5):568-584. doi: 10.1177/14550725221096908. Epub 2022 Jun 9. ABSTRACT Background and aim: Use of nicotine can harm adolescents’ brains and increase risk for future addiction to other drugs. Several international studies show that an acceptable attitude towards nicotine products increases the initiation or use of the products.
Dietary fatty acid intake in childhood and the risk of islet autoimmunity and type 1 diabetes: the DIPP birth cohort study
Eur J Nutr. 2023 Mar;62(2):847-856. doi: 10.1007/s00394-022-03035-2. Epub 2022 Oct 25. ABSTRACT PURPOSE: The aim was to study the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D). METHODS: The prospective Finnish Type 1 Diabetes Prediction and Prevention (DIPP)…
SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis
Nucleic Acids Res. 2022 Nov 11;50(20):11470-11491. doi: 10.1093/nar/gkac900. ABSTRACT Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice. Germ-cell conditional knockout (cKO) of Smg6 induces extensive…
Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis: Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study
Atherosclerosis. 2022 Nov;361:1-9. doi: 10.1016/j.atherosclerosis.2022.10.005. Epub 2022 Oct 8. ABSTRACT AIM: We aimed at identifying the shared biological processes underlying atherosclerosis-osteoporosis co/multimorbidity. METHODS: We performed gene set analysis (GSA) of whole-blood transcriptomic data to identify biological processes shared by the early markers of these two diseases. Early markers of diseases,…
Environmental toxicants and male fertility
Best Pract Res Clin Obstet Gynaecol. 2023 Feb;86:102298. doi: 10.1016/j.bpobgyn.2022.102298. Epub 2022 Dec 17. ABSTRACT Semen quality has declined especially among Western men. Experimental and epidemiological studies have shown potential links between exposure to environmental toxicants and poor male fertility. Some environmental exposures in utero can disrupt fetal testicular function…
Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex
Eur J Neurosci. 2023 Jan;57(2):242-257. doi: 10.1111/ejn.15882. Epub 2022 Dec 17. ABSTRACT Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long-lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. Several prior studies have revealed that…
Residential green environments are associated with human milk oligosaccharide diversity and composition
Sci Rep. 2023 Jan 5;13(1):216. doi: 10.1038/s41598-022-27317-1. ABSTRACT Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between properties of…
Concurrent changes in dental anxiety and smoking in parents of the FinnBrain Birth Cohort Study
Eur J Oral Sci. 2023 Feb;131(1):e12912. doi: 10.1111/eos.12912. Epub 2023 Jan 4. ABSTRACT We evaluated associations between changes in dental anxiety and tobacco use, adjusted for general anxiety and depressive symptoms. The FinnBrain Birth Cohort Study data, collected at gestational weeks 14 and 34 and at 3 months postpartum, were…
Parenthood and changes in physical activity from early adulthood to mid-life among Finnish adults
Scand J Med Sci Sports. 2023 May;33(5):682-692. doi: 10.1111/sms.14293. Epub 2023 Jan 4. ABSTRACT This study examined longitudinal associations between parenthood-related factors and physical activity from young adulthood to midlife over a 19-year follow-up period. Participants (n = 761) at the ongoing Cardiovascular Risk in Young Finns Study responded to…
