J Affect Disord. 2023 Jun 27:S0165-0327(23)00822-4. doi: 10.1016/j.jad.2023.06.056. Online ahead of print. ABSTRACT BACKGROUND: The COVID-19 pandemic has been posing widespread influence on mental well-being. However, research on the dynamic relations between alcohol use and psychological symptoms in the context of the pandemic and the role of alexithymic traits in…
Publications
Publications
Testicular Cancer: Pathogenesis, Diagnosis and Management with Focus on Endocrine Aspects
2023 Mar 29. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New…
Changes in ambulatory blood pressure during the transition to retirement
J Hypertens. 2023 Jan 1;41(1):187-193. doi: 10.1097/HJH.0000000000003320. Epub 2022 Oct 27. ABSTRACT OBJECTIVES: Retirement is a major life event characterized by removal of work-related stressors and changes in health behaviours. The association between retirement and changes in blood pressure (BP), and particularly in ambulatory BP, has been scarcely studied. We…
Associations between temperament dimensions and dental anxiety in parents of the FinnBrain Birth Cohort Study
Eur J Oral Sci. 2022 Dec;130(6):e12897. doi: 10.1111/eos.12897. Epub 2022 Oct 27. ABSTRACT We evaluated associations between dental anxiety and four temperament dimensions: effortful control, extraversion/surgency, negative affect and orienting sensitivity among 2558 parents in the FinnBrain Birth Cohort Study. Dental anxiety was measured with the Modified Dental Anxiety Scale,…
The Finnish genetic heritage in 2022 – from diagnosis to translational research
Dis Model Mech. 2022 Oct 1;15(10):dmm049490. doi: 10.1242/dmm.049490. Epub 2022 Oct 26. ABSTRACT Isolated populations have been valuable for the discovery of rare monogenic diseases and their causative genetic variants. Finnish disease heritage (FDH) is an example of a group of hereditary monogenic disorders caused by single major, usually autosomal-recessive,…
Influencing adolescents’ attitudes towards nicotine products: A systematic review
Nordisk Alkohol Nark. 2022 Oct;39(5):568-584. doi: 10.1177/14550725221096908. Epub 2022 Jun 9. ABSTRACT Background and aim: Use of nicotine can harm adolescents’ brains and increase risk for future addiction to other drugs. Several international studies show that an acceptable attitude towards nicotine products increases the initiation or use of the products.
Dietary fatty acid intake in childhood and the risk of islet autoimmunity and type 1 diabetes: the DIPP birth cohort study
Eur J Nutr. 2023 Mar;62(2):847-856. doi: 10.1007/s00394-022-03035-2. Epub 2022 Oct 25. ABSTRACT PURPOSE: The aim was to study the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D). METHODS: The prospective Finnish Type 1 Diabetes Prediction and Prevention (DIPP)…
SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis
Nucleic Acids Res. 2022 Nov 11;50(20):11470-11491. doi: 10.1093/nar/gkac900. ABSTRACT Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice. Germ-cell conditional knockout (cKO) of Smg6 induces extensive…
Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis: Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study
Atherosclerosis. 2022 Nov;361:1-9. doi: 10.1016/j.atherosclerosis.2022.10.005. Epub 2022 Oct 8. ABSTRACT AIM: We aimed at identifying the shared biological processes underlying atherosclerosis-osteoporosis co/multimorbidity. METHODS: We performed gene set analysis (GSA) of whole-blood transcriptomic data to identify biological processes shared by the early markers of these two diseases. Early markers of diseases,…
Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts
Dev Psychopathol. 2021 Dec;33(5):1837-1848. doi: 10.1017/s0954579421001012. Epub 2021 Oct 15. ABSTRACT High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research…
