Author: Henok Karvonen

Neurology. 2023 Feb 7;100(6):e568-e581. doi: 10.1212/WNL.0000000000201489. Epub 2022 Nov 16. ABSTRACT BACKGROUND AND OBJECTIVES: Whether chronic autoimmune inflammatory diseases causally affect the risk of Alzheimer disease (AD) is controversial. We characterized the relationship between inflammatory diseases and risk of AD and explored the role of circulating inflammatory biomarkers in the…

Scand J Med Sci Sports. 2023 Mar;33(3):307-318. doi: 10.1111/sms.14261. Epub 2022 Nov 16. ABSTRACT OBJECTIVE: Physical activity benefits cardiometabolic health, but little is known about its detailed links with serum lipoproteins, amino acids, and glucose metabolism at young age. We therefore studied the association of physical activity with a comprehensive…

J Hypertens. 2023 Jan 1;41(1):187-193. doi: 10.1097/HJH.0000000000003320. Epub 2022 Oct 27. ABSTRACT OBJECTIVES: Retirement is a major life event characterized by removal of work-related stressors and changes in health behaviours. The association between retirement and changes in blood pressure (BP), and particularly in ambulatory BP, has been scarcely studied. We…

Eur J Oral Sci. 2022 Dec;130(6):e12897. doi: 10.1111/eos.12897. Epub 2022 Oct 27. ABSTRACT We evaluated associations between dental anxiety and four temperament dimensions: effortful control, extraversion/surgency, negative affect and orienting sensitivity among 2558 parents in the FinnBrain Birth Cohort Study. Dental anxiety was measured with the Modified Dental Anxiety Scale,…

Dis Model Mech. 2022 Oct 1;15(10):dmm049490. doi: 10.1242/dmm.049490. Epub 2022 Oct 26. ABSTRACT Isolated populations have been valuable for the discovery of rare monogenic diseases and their causative genetic variants. Finnish disease heritage (FDH) is an example of a group of hereditary monogenic disorders caused by single major, usually autosomal-recessive,…

Nordisk Alkohol Nark. 2022 Oct;39(5):568-584. doi: 10.1177/14550725221096908. Epub 2022 Jun 9. ABSTRACT Background and aim: Use of nicotine can harm adolescents’ brains and increase risk for future addiction to other drugs. Several international studies show that an acceptable attitude towards nicotine products increases the initiation or use of the products.

Eur J Nutr. 2023 Mar;62(2):847-856. doi: 10.1007/s00394-022-03035-2. Epub 2022 Oct 25. ABSTRACT PURPOSE: The aim was to study the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D). METHODS: The prospective Finnish Type 1 Diabetes Prediction and Prevention (DIPP)…

Nucleic Acids Res. 2022 Nov 11;50(20):11470-11491. doi: 10.1093/nar/gkac900. ABSTRACT Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice. Germ-cell conditional knockout (cKO) of Smg6 induces extensive…

Atherosclerosis. 2022 Nov;361:1-9. doi: 10.1016/j.atherosclerosis.2022.10.005. Epub 2022 Oct 8. ABSTRACT AIM: We aimed at identifying the shared biological processes underlying atherosclerosis-osteoporosis co/multimorbidity. METHODS: We performed gene set analysis (GSA) of whole-blood transcriptomic data to identify biological processes shared by the early markers of these two diseases. Early markers of diseases,…

Best Pract Res Clin Obstet Gynaecol. 2023 Feb;86:102298. doi: 10.1016/j.bpobgyn.2022.102298. Epub 2022 Dec 17. ABSTRACT Semen quality has declined especially among Western men. Experimental and epidemiological studies have shown potential links between exposure to environmental toxicants and poor male fertility. Some environmental exposures in utero can disrupt fetal testicular function…