Sci Rep. 2024 Oct 26;14(1):25463. doi: 10.1038/s41598-024-75496-w. ABSTRACT Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological…
Publications
Publications
Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31-year follow-up
Aging Cell. 2024 Oct 25:e14394. doi: 10.1111/acel.14394. Online ahead of print. ABSTRACT Evidence is accumulating on the connection of early adversities and harsh family environment with epigenetic ageing. We investigated whether early psychosocial resilience is associated with epigenetic ageing in adulthood. We used the population-based Young Finns data (n =…
Bias in O-Information Estimation
Entropy (Basel). 2024 Sep 30;26(10):837. doi: 10.3390/e26100837. ABSTRACT Higher-order relationships are a central concept in the science of complex systems. A popular method of attempting to estimate the higher-order relationships of synergy and redundancy from data is through the O-information. It is an information-theoretic measure composed of Shannon entropy terms…
Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro
Andrology. 2024 Oct 18. doi: 10.1111/andr.13777. Online ahead of print. ABSTRACT BACKGROUND: Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib-treated male patients…
Predictors in Youth of Adult Cardiovascular Events
Pediatrics. 2024 Oct 14:e2024066736. doi: 10.1542/peds.2024-066736. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVES: Childhood risk factors are associated with cardiovascular events in adulthood. We compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a model that additionally included lipids to predict cardiovascular…
Changes in food habits during the transition to retirement: the Whitehall II cohort study
J Epidemiol Community Health. 2024 Oct 1:jech-2024-222690. doi: 10.1136/jech-2024-222690. Online ahead of print. ABSTRACT BACKGROUND: The transition to retirement is a significant turning point in life, which may lead to changes in food habits. OBJECTIVE: To examine changes in red meat, fish, vegetables and fruit consumption during the retirement transition…
Neonatal and early infancy antibiotic exposure is associated with childhood atopic dermatitis, wheeze and asthma
Eur J Pediatr. 2024 Sep 28. doi: 10.1007/s00431-024-05775-1. Online ahead of print. ABSTRACT Antibiotics are frequently administered in the neonatal period and early infancy. Little is known about the long-term health consequences of early life antibiotic exposure. The objective is to investigate the association between neonatal and early life (0-6…
Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19
iScience. 2024 Aug 9;27(10):110704. doi: 10.1016/j.isci.2024.110704. eCollection 2024 Oct 18. ABSTRACT We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using…
Predicting early-stage coronary artery disease using machine learning and routine clinical biomarkers improved by augmented virtual data
Eur Heart J Digit Health. 2024 Aug 9;5(5):542-550. doi: 10.1093/ehjdh/ztae049. eCollection 2024 Sep. ABSTRACT AIMS: Coronary artery disease (CAD) is a highly prevalent disease with modifiable risk factors. In patients with suspected obstructive CAD, evaluating the pre-test probability model is crucial for diagnosis, although its accuracy remains controversial. Machine learning…
Food Consumption and Risk of Islet Autoimmunity and Type 1 Diabetes in Children at Increased Genetic Susceptibility for Type 1 Diabetes
J Nutr. 2024 Sep 21:S0022-3166(24)01035-6. doi: 10.1016/j.tjnut.2024.09.018. Online ahead of print. ABSTRACT BACKGROUND: Prospective longitudinal evidence considering the entire childhood food consumption in relation to development of islet autoimmunity (IA or) type 1 diabetes is lacking. OBJECTIVES: We studied the associations of consumption of various foods and their combinations with…
