Prev Med. 2024 Sep 5:108128. doi: 10.1016/j.ypmed.2024.108128. Online ahead of print. ABSTRACT OBJECTIVE: Child and adult body mass index (BMI) associates with adult carotid artery intima-media thickness (cIMT). However, the relative contribution of BMI at different life-periods on adult cIMT has not been quantified. This study aimed to determine the…
Publications
Publications
A Clinical Tool to Relate Youth Risk Factors to Adult Cardiovascular Events and Type 2 Diabetes: The i3C Consortium
J Pediatr. 2024 Sep 2:114277. doi: 10.1016/j.jpeds.2024.114277. Online ahead of print. ABSTRACT OBJECTIVE: To translate data relating childhood cardiovascular (CV) risk factors and adult CV disease and type 2 diabetes mellitus (T2DM) to clinically actionable values. STUDY DESIGN: A prospective observational study (n=38,589) in the International Childhood Cardiovascular Cohort (i3C)…
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
Nature. 2024 Sep 4. doi: 10.1038/s41586-024-07993-x. Online ahead of print. ABSTRACT Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being…
Identification and functional characterisation of DNA methylation differences between East- and West-originating Finns
Epigenetics. 2024 Dec;19(1):2397297. doi: 10.1080/15592294.2024.2397297. Epub 2024 Sep 1. ABSTRACT Eastern and Western Finns show a striking difference in coronary heart disease-related mortality; genetics is a known contributor for this discrepancy. Here, we discuss the potential role of DNA methylation in mediating the discrepancy in cardiometabolic disease-risk phenotypes between the…
Osteosarcopenia in Finland: prevalence and associated factors
Arch Osteoporos. 2024 Aug 30;19(1):80. doi: 10.1007/s11657-024-01439-7. ABSTRACT This cross-sectional study investigated osteosarcopenia prevalence and its correlates among 2142 adults aged 55 and older in Finland. Findings show 3.9% had osteosarcopenia, while 13.8% and 11.1% had probable sarcopenia only or osteoporosis only, respectively. Osteosarcopenia was associated with low BMI, impaired…
Longitudinal associations of participation in organized and unorganized sports in youth with physical activity in mid-adulthood: The Young Finns Study
J Sports Sci. 2024 Aug 27:1-9. doi: 10.1080/02640414.2024.2386490. Online ahead of print. ABSTRACT We investigated the longitudinal associations between sports participation patterns in youth and physical activity (PA) in adulthood. PA was self-reported triannually between ages 9-18 (n = 2550, 52% females) and measured by accelerometers in mid-adulthood (n =…
Symptomatic type 1 diabetes is approaching, but when?
J Clin Endocrinol Metab. 2024 Aug 22:dgae578. doi: 10.1210/clinem/dgae578. Online ahead of print. NO ABSTRACT PMID:39171922 | DOI:10.1210/clinem/dgae578…
Childhood family environment and systemic haemodynamics in adulthood: the Cardiovascular Risk in Young Finns Study
Scand J Public Health. 2024 Aug 17:14034948241262185. doi: 10.1177/14034948241262185. Online ahead of print. ABSTRACT AIMS: Childhood family environment is associated with adulthood health behaviours and cardiovascular health, but limited data are available concerning the relationship between childhood family environment and adulthood haemodynamic determinants of blood pressure. We evaluated how childhood…
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis
BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. doi: 10.1136/bmjresp-2023-001630. ABSTRACT OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis…
A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations
Res Sq [Preprint]. 2024 Jul 17:rs.3.rs-4163414. doi: 10.21203/rs.3.rs-4163414/v1. ABSTRACT Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for…
