PLoS One. 2022 Dec 1;17(12):e0278405. doi: 10.1371/journal.pone.0278405. eCollection 2022. ABSTRACT BACKGROUND: Physical activity and body mass index (BMI) have been reported to change around retirement. The objective was to examine the concurrent changes in physical activity and BMI around retirement, which have not been studied before. In addition, the associations…
Publications
Publications
A saturated map of common genetic variants associated with human height
Nature. 2022 Oct;610(7933):704-712. doi: 10.1038/s41586-022-05275-y. Epub 2022 Oct 12. ABSTRACT Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals…
Concurrent changes in dental anxiety and smoking in parents of the FinnBrain Birth Cohort Study
Eur J Oral Sci. 2023 Feb;131(1):e12912. doi: 10.1111/eos.12912. Epub 2023 Jan 4. ABSTRACT We evaluated associations between changes in dental anxiety and tobacco use, adjusted for general anxiety and depressive symptoms. The FinnBrain Birth Cohort Study data, collected at gestational weeks 14 and 34 and at 3 months postpartum, were…
Parenthood and changes in physical activity from early adulthood to mid-life among Finnish adults
Scand J Med Sci Sports. 2023 May;33(5):682-692. doi: 10.1111/sms.14293. Epub 2023 Jan 4. ABSTRACT This study examined longitudinal associations between parenthood-related factors and physical activity from young adulthood to midlife over a 19-year follow-up period. Participants (n = 761) at the ongoing Cardiovascular Risk in Young Finns Study responded to…
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genome Biol. 2022 Dec 27;23(1):268. doi: 10.1186/s13059-022-02837-1. ABSTRACT BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.
Prenatal exposure to phenols and benzophenones in relation to markers of male reproductive function in adulthood
Front Endocrinol (Lausanne). 2022 Dec 9;13:1071761. doi: 10.3389/fendo.2022.1071761. eCollection 2022. ABSTRACT INTRODUCTION: Environmental exposure during fetal life may disrupt testicular development. In humans, a limited number of studies have investigated whether these adverse effects persist into adulthood. Using data from a prospective, population-based birth cohort study, The Copenhagen Mother-Child cohort,…
Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutation in Patients with Acute Alcohol Pancreatitis (AAP) Compared to Healthy Controls and Heavy Alcohol Users without Pancreatitis
Int J Mol Sci. 2022 Dec 11;23(24):15726. doi: 10.3390/ijms232415726. ABSTRACT Only 3-5% of heavy alcohol users develop acute alcohol pancreatitis (AAP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AAP, and SPINK1 mutation is a documented risk factor. We…
Unpredictable maternal sensory signals in caregiving behavior are associated with child effortful control
PLoS One. 2022 Dec 20;17(12):e0279384. doi: 10.1371/journal.pone.0279384. eCollection 2022. ABSTRACT Emerging evidence suggests that exposure to unpredictable patterns of maternal sensory signals during infancy is associated with child neurodevelopment, including poorer effortful control. However, longitudinal effects on child development and possible sex differences are understudied. The aims of the present…
Health-related quality of life in boys with constitutional delay of growth and puberty
Front Endocrinol (Lausanne). 2022 Nov 25;13:1028828. doi: 10.3389/fendo.2022.1028828. eCollection 2022. ABSTRACT INTRODUCTION: Constitutional delay of growth and puberty (CDGP) is the most common reason for delayed puberty in healthy male adolescents. The main indication for medical treatment for this condition is psychosocial burden. However, to the best of our knowledge,…
Work ability and physical fitness among aging workers: the Finnish Retirement and Aging Study
Eur J Ageing. 2022 Jun 22;19(4):1301-1310. doi: 10.1007/s10433-022-00714-1. eCollection 2022 Dec. ABSTRACT BACKGROUND: With advancing age, physical capacity gradually decreases which may lead to decreased work ability, if the physical work requirements remain the same. Examination of the importance of physical fitness for work ability among aging workers will help…
