JIMD Rep. 2023 Jun 20;64(4):293-299. doi: 10.1002/jmd2.12377. eCollection 2023 Jul. ABSTRACT Lysinuric protein intolerance (LPI) is a rare autosomal recessive disorder affecting the transport of cationic amino acids. Elevated plasma zinc concentrations have been described in patients with LPI. Calprotectin is a calcium- and zinc-binding protein, produced by polymorphonuclear leukocytes…
Publications
Publications
Childhood family environment predicting psychotic disorders over a 37-year follow-up – A general population cohort study
Schizophr Res. 2023 Jun 29;258:9-17. doi: 10.1016/j.schres.2023.06.008. Online ahead of print. ABSTRACT BACKGROUND: Childhood adverse effects and traumatic experiences increase the risk for several psychiatric disorders. We now investigated whether prospectively assessed childhood family environment per se contributes to increased risk for psychotic disorders in adulthood, and whether these family…
Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
Cell Rep Med. 2023 Jun 23:101093. doi: 10.1016/j.xcrm.2023.101093. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study…
Associations of breastfeeding duration with serum lipid values from infancy until age 20 years – the STRIP study
Scand J Public Health. 2023 Jun 30:14034948231183030. doi: 10.1177/14034948231183030. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: The effect of breastfeeding duration on childhood lipid levels has remained controversial. In this study, we aimed to establish the long-term associations of breastfeeding duration with future levels of total cholesterol, high-density lipoprotein…
Longitudinal patterns of alcohol use and psychological symptoms during COVID-19 pandemic and role of alexithymia: A latent transition analysis in the FinnBrain Birth Cohort Study
J Affect Disord. 2023 Jun 27:S0165-0327(23)00822-4. doi: 10.1016/j.jad.2023.06.056. Online ahead of print. ABSTRACT BACKGROUND: The COVID-19 pandemic has been posing widespread influence on mental well-being. However, research on the dynamic relations between alcohol use and psychological symptoms in the context of the pandemic and the role of alexithymic traits in…
Testicular Cancer: Pathogenesis, Diagnosis and Management with Focus on Endocrine Aspects
2023 Mar 29. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New…
Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias
Chemosphere. 2023 Feb;313:137343. doi: 10.1016/j.chemosphere.2022.137343. Epub 2022 Nov 21. ABSTRACT Hypospadias is a congenital malformation of penile urethra with unknown etiology in most cases. Persistent organic pollutant (POP) exposure may disrupt endocrine function during a critical window of development of male genitalia. In animal studies, POPs have been associated with…
Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study
BMC Endocr Disord. 2022 Nov 18;22(1):284. doi: 10.1186/s12902-022-01197-y. ABSTRACT PURPOSE: To investigate whether exposure to systemic antibiotics influences the risk of developing type 2 diabetes and overweight/obesity. METHODS: The study sample comprised 2209 (110 with incident diabetes) participants from the population-based Cardiovascular Risk in Young Finns Study (YFS) aged 24-39…
The associations of childhood psychosocial factors with cognitive function in midlife-The young finns study
Neuropsychology. 2023 Jan;37(1):64-76. doi: 10.1037/neu0000877. Epub 2022 Nov 17. ABSTRACT OBJECTIVE: An adverse psychosocial environment in childhood may harm cognitive development, but the associations for adulthood cognitive function remain obscure. We tested the hypothesis that adverse childhood psychosocial factors associate with poor cognitive function in midlife by leveraging the prospective…
Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization
Neurology. 2023 Feb 7;100(6):e568-e581. doi: 10.1212/WNL.0000000000201489. Epub 2022 Nov 16. ABSTRACT BACKGROUND AND OBJECTIVES: Whether chronic autoimmune inflammatory diseases causally affect the risk of Alzheimer disease (AD) is controversial. We characterized the relationship between inflammatory diseases and risk of AD and explored the role of circulating inflammatory biomarkers in the…
