Horm Res Paediatr. 2022 Dec 7. doi: 10.1159/000528567. Online ahead of print. ABSTRACT INTRODUCTION: Newborn screening of congenital hypothyroidism (CH) has enabled early treatment with levothyroxine (LT4), ensuring normal growth and development. The initial LT4 dose recommendation has increased over decades. We evaluated whether the increased LT4 dosing influenced thyroid-stimulating…
Publications
Publications
Genetic analyses implicate complex links between adult testosterone levels and health and disease
Commun Med (Lond). 2023 Jan 18;3(1):4. doi: 10.1038/s43856-022-00226-0. ABSTRACT BACKGROUND: Testosterone levels are linked with diverse characteristics of human health, yet, whether these associations reflect correlation or causation remains debated. Here, we provide a broad perspective on the role of genetically determined testosterone on complex diseases in both sexes. METHODS:…
Inflammatory biomarkers after an exercise intervention in childhood acute lymphoblastic leukemia survivors
EJHaem. 2022 Sep 29;3(4):1188-1200. doi: 10.1002/jha2.588. eCollection 2022 Nov. ABSTRACT Cancer survivors show increased risk for non-communicable diseases and chronic low-grade inflammation characterizes the development of such diseases. We investigated inflammatory plasma protein profiles of survivors of childhood acute lymphoblastic leukemia (ALL) in comparison to healthy controls and after an…
Polygenic risk for neuroticism is associated with externalizing symptoms in 2-year-old boys
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Apr 20;123:110720. doi: 10.1016/j.pnpbp.2023.110720. Epub 2023 Jan 14. ABSTRACT Recent advances in genome-wide association studies have enabled the estimation of genetic risk of complex traits, including neuroticism, with polygenic risk scores (PRS). Neuroticism PRS has been associated with psychiatric disorders and symptoms in adults, but…
STAGETOOL, a Novel Automated Approach for Mouse Testis Histological Analysis
Endocrinology. 2022 Dec 19;164(2):bqac202. doi: 10.1210/endocr/bqac202. ABSTRACT Spermatogenesis is a complex differentiation process that takes place in the seminiferous tubules. A specific organization of spermatogenic cells within the seminiferous epithelium enables a synchronous progress of germ cells at certain steps of differentiation on the spermatogenic pathway. This can be observed…
Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes
Andrology. 2023 May;11(4):710-723. doi: 10.1111/andr.13361. Epub 2023 Jan 9. ABSTRACT BACKGROUND: Germ granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in meiotic spermatocytes and the chromatoid body (CB) in haploid round…
Long-term residential sunlight exposure associated with cognitive function among adults residing in Finland
Sci Rep. 2022 Dec 2;12(1):20818. doi: 10.1038/s41598-022-25336-6. ABSTRACT While sunlight may influence cognitive function through several pathways, associations of residential sunlight exposure with cognitive function are not well known. We evaluated associations of long-term residential sunlight exposure with cognitive function among a representative cohort of 1838 Finnish adults residing in…
Environmental toxicants and male fertility
Best Pract Res Clin Obstet Gynaecol. 2023 Feb;86:102298. doi: 10.1016/j.bpobgyn.2022.102298. Epub 2022 Dec 17. ABSTRACT Semen quality has declined especially among Western men. Experimental and epidemiological studies have shown potential links between exposure to environmental toxicants and poor male fertility. Some environmental exposures in utero can disrupt fetal testicular function…
Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex
Eur J Neurosci. 2023 Jan;57(2):242-257. doi: 10.1111/ejn.15882. Epub 2022 Dec 17. ABSTRACT Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long-lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. Several prior studies have revealed that…
Residential green environments are associated with human milk oligosaccharide diversity and composition
Sci Rep. 2023 Jan 5;13(1):216. doi: 10.1038/s41598-022-27317-1. ABSTRACT Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between properties of…
