Nat Med. 2025 Jul 21. doi: 10.1038/s41591-025-03827-z. Online ahead of print. ABSTRACT Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European…
Publications
Publications
Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study
Atherosclerosis. 2025 Jul 12;408:120426. doi: 10.1016/j.atherosclerosis.2025.120426. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Population based data are limited on the prevalence of carotid atherosclerosis across broad age-ranges from early childhood to old age. We aimed to determine the prevalence and determinants of carotid artery plaques in a Finnish population.
Life-course neighbourhood socioeconomic disadvantage and atherosclerotic carotid artery plaques. The Cardiovascular Risk in Young Finns Study
medRxiv [Preprint]. 2025 Jul 8:2025.07.07.25331069. doi: 10.1101/2025.07.07.25331069. ABSTRACT BACKGROUND: Neighbourhood socioeconomic disadvantage is a known determinant of cardiovascular disease (CVD) risk. However, its impact on subclinical atherosclerosis across the life course remains inadequately understood. This study examined the association between cumulative neighbourhood socioeconomic disadvantage from childhood to midlife and carotid…
A phenome-wide association study of genetically determined nicotine metabolism reveals novel links with health-related outcomes
Eur J Epidemiol. 2025 Jul 12. doi: 10.1007/s10654-025-01270-5. Online ahead of print. ABSTRACT Faster nicotine metabolism, defined as the nicotine metabolite ratio (NMR), is known to associate with heavier smoking and challenges in smoking cessation. However, the broader health implications of genetically determined nicotine metabolism are not well characterized. We…
Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study
Lancet Healthy Longev. 2025 Jun;6(6):100717. doi: 10.1016/j.lanhl.2025.100717. ABSTRACT BACKGROUND: Blood-based biomarkers (BBM) of neurodegenerative diseases are emerging as cost-effective tools in the differential diagnostics of Alzheimer’s disease and other dementias. Scarce data exist about factors explaining BBM variation in population-based cohorts, and their intergenerational associations are unknown. This study aimed…
Insomnia and sleepiness during pregnancy: Associations with gestational diabetes mellitus
Acta Obstet Gynecol Scand. 2025 Jul 11. doi: 10.1111/aogs.70013. Online ahead of print. ABSTRACT INTRODUCTION: Sleep quality typically deteriorates during pregnancy, and poor sleep is a risk factor for pregnancy complications, including gestational diabetes mellitus (GDM). The present study is the first longitudinal study addressing associations between sleep quality and…
Latent Profiles of Early Language Development in a Large Finnish-Speaking Sample of the FinnBrain Birth Cohort Study
J Speech Lang Hear Res. 2025 Jul 10:1-17. doi: 10.1044/2025_JSLHR-24-00767. Online ahead of print. ABSTRACT PURPOSE: Research on early language development has primarily used two categories to group at-risk children, differing by the age at which risk is identified. Late talkers are toddlers with late onset of language development, some…
The associations between intergenerational mobility of income and cognitive function in midlife-The Young Finns Study
Soc Sci Med. 2025 Jun 27;382:118325. doi: 10.1016/j.socscimed.2025.118325. Online ahead of print. ABSTRACT BACKGROUND: Systematically high and upward mobile (lower childhood and higher adulthood) socioeconomic status (SES) has been suggested to be associated with better overall cognitive function in adulthood compared to systematically low or downward mobile (high childhood and…
NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis
Nat Commun. 2025 Jul 7;16(1):6254. doi: 10.1038/s41467-025-61463-0. ABSTRACT In eukaryotes, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, NXT1 has an X-chromosomal paralog, NXT2, which exhibits testis-enriched expression, suggesting a role in spermatogenesis. Here, we report the…
Concurrent Changes in 24-Hour Movement Behaviors and Cognitive Function during Retirement Transition: Longitudinal Compositional Data Analysis
Med Sci Sports Exerc. 2025 Jul 4. doi: 10.1249/MSS.0000000000003801. Online ahead of print. ABSTRACT BACKGROUND: Transitioning to retirement may change physical activity, sedentary behavior, and sleep, i.e., 24-h movement behaviors, but it is unknown whether these changes are linked to cognitive function. This study investigates the longitudinal associations between changes…
