Longitudinal Micronutrient Exposure Reveals Country-Specific Associations with Risk of Celiac Disease in Genetically Susceptible Children: The Prospective TEDDY Cohort: Nutrient Intake and Risk of Celiac Disease

Am J Clin Nutr. 2026 Mar 16:101276. doi: 10.1016/j.ajcnut.2026.101276. Online ahead of print. ABSTRACT BACKGROUND: The role of nutrient intake in celiac disease pathogenesis is poorly understood. OBJECTIVE: To examine whether longitudinal childhood intake of selected vitamins and minerals is associated with celiac disease autoimmunity (CDA, primary outcome) and celiac…

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Prognostic potential of circulatory miR-19a-3p, miR-19b-3p, and miR-329-3p for future hypertension diagnosis

J Hypertens. 2026 Feb 19. doi: 10.1097/HJH.0000000000004272. Online ahead of print. ABSTRACT MicroRNAs have been suggested as essential hypertension biomarkers, but evidence remains inconclusive due to limited high-throughput studies in population cohorts. We analyzed data from the Young Finns Study (YFS) from 2011 and 2018-2020 to assess cross-sectional and prospective…

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Finnish-Enriched SLC26A7 Variant in Congenital Hypothyroidism: Clinical Spectrum, Thyroid Histopathology, and Expression Analysis

Thyroid. 2026 Feb;36(2):141-152. doi: 10.1177/10507256251411983. Epub 2026 Jan 22. ABSTRACT BACKGROUND: Defects in thyroid hormone synthesis at birth lead to congenital hypothyroidism (CH). Recently, pathogenic variants in the SLC26A7 gene have been linked to dyshormonogenetic goitrous CH. This anion transporter is highly expressed in the thyroid and is involved in…

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Genetic susceptibility to Alzheimer’s disease and cardiometabolic risk from childhood

Pediatr Res. 2026 Mar 5. doi: 10.1038/s41390-026-04860-5. Online ahead of print. ABSTRACT BACKGROUND: We investigated the associations of genetic risk score for Alzheimer’s disease (GRS-AD) with cardiometabolic risk from early childhood over a 20-year follow-up. METHODS: The STRIP study included 1062 children at baseline. GRS-AD was calculated for 631 participants…

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Early-life immunological and microbial differences between East African and North European children

Commun Med (Lond). 2026 Mar 3. doi: 10.1038/s43856-026-01482-0. Online ahead of print. ABSTRACT BACKGROUND: The urbanization of African populations adopting Westernized lifestyles might be connected to changes in microbial exposure and immune system activity that are harmful to health and increase the risk of non-communicable diseases, such as immune-mediated diseases.

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Marine n-3 long-chain polyunsaturated fatty acid intake in pregnancy and risk of early life infections in three Nordic cohorts: a HEDIMED consortium study

J Nutr. 2026 Feb 28:101456. doi: 10.1016/j.tjnut.2026.101456. Online ahead of print. ABSTRACT BACKGROUND: n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) have anti-inflammatory effects that may influence immune-mediated diseases. OBJECTIVE: We investigated whether higher maternal pregnancy intake of n-3 LCPUFA is associated with a lower infection incidence in young children. METHODS:…

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Prenatal Parental Psychosocial Determinants of Neonatal Brain Structure: A Latent Variable Approach in the FinnBrain Birth Cohort

Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Feb 25:S2451-9022(26)00048-0. doi: 10.1016/j.bpsc.2026.02.004. Online ahead of print. ABSTRACT BACKGROUND: Maternal mental health during pregnancy has been linked to early neurodevelopment, but the unique contributions of maternal and paternal psychosocial risk and protective factors to neonatal brain structure remain unclear. This study examined associations…

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Meta-analysis of genome-wide association studies of food allergy and IgE-sensitization

J Allergy Clin Immunol. 2026 Feb 20:S0091-6749(26)00093-X. doi: 10.1016/j.jaci.2026.02.012. Online ahead of print. ABSTRACT BACKGROUND: Food allergies (FA) arise from a complex interplay between an individual’s genetic predisposition and environmental factors and their prevalence is increasing. Genome-wide association studies (GWAS) to date have been hindered by small sample sizes and…

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Childhood exposure to multiple persistent organic pollutants and midlife cognitive function

Sci Total Environ. 2026 Feb 19;1020:181552. doi: 10.1016/j.scitotenv.2026.181552. Online ahead of print. ABSTRACT INTRODUCTION: Whether early-life exposure to persistent organic pollutants (POPs) associates with adult cognitive function is unknown. We examined the association of childhood serum POPs levels with cognitive function in midlife. METHODS: This was a prospective cohort study…

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EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data

Epigenomics. 2026 Feb 17:1-11. doi: 10.1080/17501911.2026.2630841. Online ahead of print. ABSTRACT AIM: Tobacco smoking induces persistent DNA methylation (DNAm) changes in blood that can serve as long-term biomarkers for smoking exposure. We aimed to develop and validate a DNAm classifier of smoking status using Illumina EPIC array data. METHODS: We…

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