A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations

Res Sq [Preprint]. 2025 Feb 17:rs.3.rs-6025759. doi: 10.21203/rs.3.rs-6025759/v1. ABSTRACT Background Gene-environment interactions may enhance our understanding of hypertension. Our previous study highlighted the importance of considering psychosocial factors in gene discovery for blood pressure (BP) but was limited in statistical power and population diversity. To address these challenges, we conducted…

Associations of 24-h Movement Behaviors With Incidence of Cardiovascular Risk Factors: The Finnish Retirement and Aging Study

Scand J Med Sci Sports. 2025 Feb;35(2):e70030. doi: 10.1111/sms.70030. ABSTRACT Low physical activity, high sedentary time (SED), and inadequate sleep increase cardiovascular disease risk, but the codependency between these 24-h movement behaviors has often been neglected. This study examined associations between 24-h movement behaviors and incidence of cardiovascular risk factors.

From Parents to Children: The Intergenerational Transference of Parents’ Sport Club Participation From Childhood to Adolescence: The 40-Year Young Finns Study

J Phys Act Health. 2025 Feb 19:1-9. doi: 10.1123/jpah.2024-0368. Online ahead of print. ABSTRACT BACKGROUND: Physical activity has been shown to transfer across generations, but more information is needed regarding the transference of different physical activity modes. This study examined (1) whether parents’ sport club participation at the ages 9-18…

Sociodemographic and work-related determinants of self-rated health trajectories: a collaborative meta-analysis of cohort studies from Europe and the US

Sci Rep. 2025 Feb 13;15(1):5394. doi: 10.1038/s41598-025-89947-5. ABSTRACT Self-rated health is a major indicator of an individual’s overall health status, but its development during midlife to old age, as well as influence of sociodemographic and work-related factors on it, are poorly understood. We used longitudinal individual-level data to examine trajectories…

Associations between maternal pre-pregnancy BMI and mean diffusivity of the hippocampus and amygdala in infants

Int J Obes (Lond). 2025 Feb 11. doi: 10.1038/s41366-025-01730-8. Online ahead of print. ABSTRACT BACKGROUND: Maternal pre-pregnancy obesity may negatively affect offspring outcomes, including neurodevelopment. This study examined the relationship between maternal pre-pregnancy body mass index (MBMI) and the microstructure of the hippocampus and amygdala in neonates. METHODS: Diffusion tensor…

Continuous glucose monitor metrics from five studies identify participants at risk for type 1 diabetes development

Diabetologia. 2025 Feb 11. doi: 10.1007/s00125-025-06362-1. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: We aimed to assess whether continuous glucose monitor (CGM) metrics can accurately predict stage 3 type 1 diabetes diagnosis in those with islet autoantibodies (AAb). METHODS: Baseline CGM data were collected from participants with ≥1 positive AAb type…

Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study

Lancet Public Health. 2025 Feb;10(2):e124-e135. doi: 10.1016/S2468-2667(24)00300-1. ABSTRACT BACKGROUND: Regular physical activity is recommended for all aged 5 years and older, but the health benefits gained might differ across population subgroups. The aim of this study was to examine these benefits in terms of years lived free from major non-communicable…

Childhood family environment and μ-opioid receptor availability in vivo in adulthood

Neuropsychopharmacology. 2025 Jan 31. doi: 10.1038/s41386-025-02059-6. Online ahead of print. ABSTRACT Animal studies have reported associations of early maternal separation with altered μ-opioid receptor function but data on humans are scarce. We now investigated whether childhood family environment is related to μ-opioid receptor availability in the human brain in adulthood.

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