A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol

EBioMedicine. 2026 Jan 30;124:106144. doi: 10.1016/j.ebiom.2026.106144. Online ahead of print. ABSTRACT BACKGROUND: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors from de novo biosynthesis.

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Intravenous Glucagon Infusion in the Management of Hypoglycemia in Infants of Diabetic Mothers

Am J Perinatol. 2026 Jan 29. doi: 10.1055/a-2788-2020. Online ahead of print. ABSTRACT This study aimed to evaluate the efficacy and safety of continuous intravenous (IV) glucagon infusion in the management of neonatal hypoglycemia in infants of diabetic mothers (IDMs).This retrospective case-control study included IDMs treated for hypoglycemia at Turku…

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Thyroid autoimmunity and the subsequent development of islet and celiac autoimmunity in the TEDDY study

Am J Epidemiol. 2026 Jan 23:kwag016. doi: 10.1093/aje/kwag016. Online ahead of print. ABSTRACT We aimed to determine if thyroid autoimmunity is associated with a child’s risk for subsequent development of islet or celiac autoantibodies. Children at high genetic risk of type 1 diabetes were followed for thyroid autoimmunity (thyroid peroxidase…

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Aperiodic parameters of the fMRI power spectrum associate with preterm birth and neonatal age

Commun Biol. 2026 Jan 23. doi: 10.1038/s42003-025-09488-5. Online ahead of print. ABSTRACT Perinatal period is a critical time for brain development and premature-born children have an elevated likelihood for neurodevelopmental conditions. While strong associations of structural magnetic resonance imaging with preterm birth and post-menstrual age (PMA) have been reported, results…

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Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics

Pediatr Res. 2026 Jan 15. doi: 10.1038/s41390-025-04726-2. Online ahead of print. ABSTRACT BACKGROUND: Elevated pre-pregnancy body mass index (BMI) and perinatal depressive symptoms have been linked to neonatal alterations in brain structure and function. This study examined associations between neonatal functional brain dynamics, maternal BMI, and perinatal depressive symptoms measured…

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Cardiovascular Risk Factors From Early Childhood and Cognitive Function in Young Adulthood

Pediatrics. 2026 Jan 15:e2025071353. doi: 10.1542/peds.2025-071353. Online ahead of print. ABSTRACT OBJECTIVE: Cardiovascular health promotion in adulthood is crucial for early prevention of cognitive decline, but prior data on the role of promotion starting from infancy are scarce. We studied the associations between cardiovascular risk factors from infancy to young…

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Polygenic risk for schizophrenia predicting test-measured and self-reported cognitive performance in individuals without psychosis

BMC Psychiatry. 2026 Jan 12. doi: 10.1186/s12888-026-07775-x. Online ahead of print. ABSTRACT INTRODUCTION: Schizophrenia is characterized by weaker test-measured cognitive performance, which is partially explained by disease-related secondary factors (after the onset of the disorder) such as side effects of antipsychotics, stigma, or sedentary behavior. We examined whether polygenic risk…

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Familial aggregation of leisure-time physical activity across three generations: The Cardiovascular Risk in Young Finns Study

Scand J Public Health. 2026 Jan 11:14034948251395569. doi: 10.1177/14034948251395569. Online ahead of print. ABSTRACT AIMS: Leisure-time physical activity (LTPA) is known to be hereditary for two generations, but its transmission beyond that is less studied. This study examined LTPA aggregation in three-generation families. METHODS: Data on self-reported LTPA were extracted…

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A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations

HGG Adv. 2026 Jan 10:100566. doi: 10.1016/j.xhgg.2026.100566. Online ahead of print. ABSTRACT Gene-environment interactions may enhance our understanding of blood pressure (BP) biology. We conducted a meta-analysis of multi-population genome-wide association studies of BP traits accounting for gene-depressive symptomatology (DEPR) interactions. Our study included 564,680 adults from 67 cohorts and…

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