EBioMedicine. 2026 Jan 30;124:106144. doi: 10.1016/j.ebiom.2026.106144. Online ahead of print. ABSTRACT BACKGROUND: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors from de novo biosynthesis.

