BMC Med. 2023 Feb 14;21(1):57. doi: 10.1186/s12916-023-02743-8. ABSTRACT BACKGROUND: An extensive body of animal literature supports the premise that maternal obesity during pregnancy can alter the development of the fetal hypothalamus (HTH, a critical regulator of energy balance) with implications for offspring obesity risk (i.e., long-term energy imbalance). Yet, the…