Publications

Int J Obes (Lond). 2023 Jun;47(6):453-462. doi: 10.1038/s41366-023-01281-w. Epub 2023 Feb 23. ABSTRACT BACKGROUND/OBJECTIVE: This observational study dissects the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR) and circulating metabolomics using a combination of longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. SUBJECTS/METHODS: Firstly, a data-driven…

Sci Rep. 2023 Feb 22;13(1):3078. doi: 10.1038/s41598-023-30168-z. ABSTRACT Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and plasma lipidome (phenotype) in order to identify the genetic architecture of…

Br J Nutr. 2023 Feb 21:1-11. doi: 10.1017/S0007114523000466. Online ahead of print. ABSTRACT The current definition of dietary fibre was adopted by the Codex Alimentarius Commission in 2009, but implementation requires updating food composition databases with values based on appropriate analysis methods. Previous data on population intakes of dietary fibre…

J Med Virol. 2023 Apr;95(4):e28707. doi: 10.1002/jmv.28707. ABSTRACT This study investigated whether children with HLA-DQ-conferred risk for type 1 diabetes (T1D) have an altered immune response to the widely-used enterovirus vaccine, namely poliovirus vaccine, and whether initiation of autoimmunity to pancreatic islets modulates this response. Neutralizing antibodies induced by the…

Metabolomics. 2023 Mar 24;19(4):20. doi: 10.1007/s11306-023-01994-z. ABSTRACT INTRODUCTION: Aberrations in circulating metabolites have been associated with diabetes and cardiovascular risk. OBJECTIVES: To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic. METHODS: An NMR…

Hum Brain Mapp. 2023 May;44(7):2712-2725. doi: 10.1002/hbm.26238. Epub 2023 Mar 22. ABSTRACT The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and…

Front Psychiatry. 2023 Apr 18;14:1018797. doi: 10.3389/fpsyt.2023.1018797. eCollection 2023. ABSTRACT INTRODUCTION: Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current…

J Intern Med. 2023 May 4. doi: 10.1111/joim.13648. Online ahead of print. ABSTRACT The etiology of type 1 diabetes (T1D) foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of T1D. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A),…

Diabetes Care. 2023 May 4:dc230036. doi: 10.2337/dc23-0036. Online ahead of print. ABSTRACT OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years. RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of…

Acta Diabetol. 2023 Apr 28. doi: 10.1007/s00592-023-02064-5. Online ahead of print. ABSTRACT AIMS: Deep metagenomics offers an advanced tool for examining the relationship between gut microbiota composition and function and the onset of disease; in this case, does the composition and function of gut microbiota during pregnancy differ in women…