Gut microbiota composition and function in pregnancy as determinants of prediabetes at two-year postpartum

Acta Diabetol. 2023 Apr 28. doi: 10.1007/s00592-023-02064-5. Online ahead of print. ABSTRACT AIMS: Deep metagenomics offers an advanced tool for examining the relationship between gut microbiota composition and function and the onset of disease; in this case, does the composition and function of gut microbiota during pregnancy differ in women…

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Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts

Pediatr Allergy Immunol. 2023 Apr;34(4):e13945. doi: 10.1111/pai.13945. ABSTRACT BACKGROUND: Urban-related nature exposures are suggested to contribute to the rising prevalence of allergic diseases despite little supporting evidence. Our aim was to evaluate the impact of 12 land cover classes and two greenness indices around homes at birth on the development…

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Hair cortisol, cortisone and DHEA concentrations and the composition of microbiota in toddlers

Psychoneuroendocrinology. 2023 Aug;154:106309. doi: 10.1016/j.psyneuen.2023.106309. Epub 2023 May 25. ABSTRACT Animal research suggests that the gut microbiota and the HPA axis communicate in a bidirectional manner. However, human data, especially on early childhood, remain limited. In this exploratory design, we investigated the connections between long-term HPA axis functioning, measured as…

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Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis

Epigenetics. 2023 Dec;18(1):2211361. doi: 10.1080/15592294.2023.2211361. ABSTRACT BACKGROUND: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. METHODS: We meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association…

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Investigating the role of relationship satisfaction and paternal psychological distress during pregnancy on offspring health in early life

BJPsych Open. 2023 May 25;9(3):e100. doi: 10.1192/bjo.2023.59. ABSTRACT BACKGROUND: The research on the role of father in the foetal programming of health and behaviour has received increasing attention. However, the influences of paternal depressive symptoms and couple relationship satisfaction during pregnancy – potentially mediated via maternal well-being – on the…

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Modifications of 24-h movement behaviors to prevent obesity in retirement: a natural experiment using compositional data analysis

Int J Obes (Lond). 2023 May 23. doi: 10.1038/s41366-023-01326-0. Online ahead of print. ABSTRACT BACKGROUND: Retirement often leads to a more passive lifestyle and may therefore lead to weight gain. This study aims to investigate longitudinal associations between changes in 24-h movement behaviors and BMI and waist circumference in relation…

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Tracking of Cardiorespiratory Fitness and Physical Activity from Youth to Young Adulthood: Findings from the Prospective Special Turku Coronary Risk Factor Intervention Project (STRIP)

J Pediatr X. 2023 Feb 28;9:100085. doi: 10.1016/j.ympdx.2023.100085. eCollection 2023 Summer. ABSTRACT Using data from the Special Turku Coronary Risk Factor Intervention Project, cardiorespiratory fitness (rank-order correlation coefficient = 0.60-0.62) tracked stronger than physical activity (rank-order correlation coefficient = 0.27-0.38) between youth (age = 17 years) and young adulthood (age…

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