Clin Epigenetics. 2025 Apr 29;17(1):68. doi: 10.1186/s13148-025-01871-7. ABSTRACT Non-coding 886 (nc886, vtRNA2-1) is a polymorphically imprinted gene. The methylation status of this locus has been shown to be associated with periconceptional conditions, and both the methylation status and the levels of nc886 RNAs have been shown to associate with later-life…
Author: Henok Karvonen
Childhood 25-OH-vitamin D Levels Predict Early Cardiovascular Outcomes in Adulthood: The Cardiovascular Risk in Young Finns Study
Eur J Prev Cardiol. 2025 Apr 29:zwaf271. doi: 10.1093/eurjpc/zwaf271. Online ahead of print. NO ABSTRACT PMID:40296578 | DOI:10.1093/eurjpc/zwaf271…
Association of multimorbidity with working life expectancy among adults aged 50 years and older: Findings from two prospective cohort studies
J Multimorb Comorb. 2025 Apr 15;15:26335565251331187. doi: 10.1177/26335565251331187. eCollection 2025 Jan-Dec. ABSTRACT BACKGROUND: Individual diseases are important risk factors for early exit from the labour force among older adults, but the contribution of multimorbidity to working life expectancy (WLE) is unclear. METHODS: We used data from two prospective cohort studies:…
Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Diabetes Care. 2025 Apr 24:dc242886. doi: 10.2337/dc24-2886. Online ahead of print. ABSTRACT In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at…
Measuring adverse childhood experiences by interviewing children at 9 and 10 years of age: Prevalence, concordance with mother-reports, posttraumatic stress disorder symptoms, and subjective experience of being asked about adverse childhood experiences in FinnBrain Birth cohort study
J Exp Child Psychol. 2025 Apr 18;256:106238. doi: 10.1016/j.jecp.2025.106238. Online ahead of print. ABSTRACT How children experience the screening of adverse childhood experiences (ACEs) is little studied. Moreover, the similarity between parental and child reports is unknown. We interviewed 9-year-olds (a subsample of the FinnBrain Birth Cohort Study; N =…
Impact of retirement transition on health, well-being and health behaviours: critical insights from an overview of reviews
Soc Sci Med. 2025 Apr 3;375:118049. doi: 10.1016/j.socscimed.2025.118049. Online ahead of print. ABSTRACT Retirement is a pivotal life course transition wich may have profound implications for health, well-being and health behaviours. Despite extensive research and theoretical debate, the impact of retirement on health remains inconclusive, with studies reporting positive, negative,…
The FinnBrain multimodal neonatal template and atlas collection
Commun Biol. 2025 Apr 11;8(1):600. doi: 10.1038/s42003-025-07963-7. ABSTRACT The accurate processing of neonatal and infant brain MRI data is crucial for developmental neuroscience but presents unique challenges that child and adult data do not. Tissue segmentation and image coregistration accuracy can be improved by optimizing template images and related segmentation…
Infant Subcortical Brain Volumes Associated with Maternal Obesity and Diabetes: A Large Multicohort Study
medRxiv [Preprint]. 2025 Mar 27:2025.03.25.25324641. doi: 10.1101/2025.03.25.25324641. ABSTRACT IMPORTANCE: Maternal diabetes (MD) and maternal obesity (MO) have been robustly established to confer health risks in offspring. Additionally, mounting evidence suggests that these fetal programming effects vary by sex, but whether these factors independently or interactively influence infant brain development remains…
Changes in Oral Health-Related Quality of Life According to Public Oral Health Procedures in Parents of Young Children From the FinnBrain Birth Cohort Study
Community Dent Oral Epidemiol. 2025 Apr 4. doi: 10.1111/cdoe.13039. Online ahead of print. ABSTRACT OBJECTIVES: The aim was to evaluate the association between public oral healthcare procedures and change in oral health-related quality of life (OHRQoL) over 4 years among parents in the FinnBrain Cohort Study, comparing those who did…
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations
Mol Psychiatry. 2025 Apr 4. doi: 10.1038/s41380-025-02954-w. Online ahead of print. ABSTRACT Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration…
