Environ Int. 2025 Sep 3;203:109779. doi: 10.1016/j.envint.2025.109779. Online ahead of print. ABSTRACT Polychlorinated biphenyls (PCBs) have been identified as diabetogens and potential epigenetic regulators. Epigenetic variation is implicated in the pathogenesis of type 2 diabetes (T2D) and is therefore a potential mechanism linking PCB exposure and T2D. We here investigate…
Author: Henok Karvonen
Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium
Mol Psychiatry. 2025 Sep 6. doi: 10.1038/s41380-025-03203-w. Online ahead of print. ABSTRACT Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual…
Pre- and postnatal maternal depressive symptoms associate with local connectivity of the left amygdala in 5-year-olds
Eur Psychiatry. 2025 Sep 5:1-29. doi: 10.1192/j.eurpsy.2025.10097. Online ahead of print. NO ABSTRACT PMID:40908266 | DOI:10.1192/j.eurpsy.2025.10097…
Continuity and Changes in Work Commuting Modes and Their Associations With Overall Physical Activity and Weight Status Among Finnish Adults
J Phys Act Health. 2025 Aug 19:1-9. doi: 10.1123/jpah.2024-0644. Online ahead of print. ABSTRACT BACKGROUND: This paper aims to examine and compare the levels and changes in physical activity (PA) and weight status over an 11-year follow-up among adults with varying commuting modes to work. METHODS: Overall, 1357 Finnish adults…
Concurrent changes in sleep and cognitive function during retirement transition: the Finnish retirement and aging study
Eur J Ageing. 2025 Aug 7;22(1):40. doi: 10.1007/s10433-025-00876-8. ABSTRACT The transition to retirement has been shown to be accompanied by increased sleep duration and improved sleep quality. In addition, some studies suggest accelerated decline in cognitive function in post-retirement years. However, less is known about their interconnectedness. The aim of…
Device-Measured Sleep Characteristics, Daily Step Count, and Cardiometabolic Health Markers: Findings From the Prospective Physical Activity, Sitting, and Sleep (ProPASS) Consortium
Circ Cardiovasc Qual Outcomes. 2025 Jul 24:e011873. doi: 10.1161/CIRCOUTCOMES.124.011873. Online ahead of print. ABSTRACT BACKGROUND: Sleep and physical activity (PA) are important lifestyle-related behaviors that impact cardiometabolic health. This study investigated the joint associations of daily step count and sleep patterns (regularity and duration) with cardiometabolic biomarkers in adults. METHODS:…
Polygenic prediction of body mass index and obesity through the life course and across ancestries
Nat Med. 2025 Jul 21. doi: 10.1038/s41591-025-03827-z. Online ahead of print. ABSTRACT Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European…
Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study
Atherosclerosis. 2025 Jul 12;408:120426. doi: 10.1016/j.atherosclerosis.2025.120426. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Population based data are limited on the prevalence of carotid atherosclerosis across broad age-ranges from early childhood to old age. We aimed to determine the prevalence and determinants of carotid artery plaques in a Finnish population.
Life-course neighbourhood socioeconomic disadvantage and atherosclerotic carotid artery plaques. The Cardiovascular Risk in Young Finns Study
medRxiv [Preprint]. 2025 Jul 8:2025.07.07.25331069. doi: 10.1101/2025.07.07.25331069. ABSTRACT BACKGROUND: Neighbourhood socioeconomic disadvantage is a known determinant of cardiovascular disease (CVD) risk. However, its impact on subclinical atherosclerosis across the life course remains inadequately understood. This study examined the association between cumulative neighbourhood socioeconomic disadvantage from childhood to midlife and carotid…
A phenome-wide association study of genetically determined nicotine metabolism reveals novel links with health-related outcomes
Eur J Epidemiol. 2025 Jul 12. doi: 10.1007/s10654-025-01270-5. Online ahead of print. ABSTRACT Faster nicotine metabolism, defined as the nicotine metabolite ratio (NMR), is known to associate with heavier smoking and challenges in smoking cessation. However, the broader health implications of genetically determined nicotine metabolism are not well characterized. We…
