medRxiv [Preprint]. 2025 Oct 7:2025.10.06.25337440. doi: 10.1101/2025.10.06.25337440. ABSTRACT Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies in…

Comput Inform Nurs. 2025 Dec 29. doi: 10.1097/CIN.0000000000001393. Online ahead of print. ABSTRACT The aim of this study was to predict and explain parenting stress at 3 months after the delivery with pregnancy-related features collected in different stages of pregnancy using generalized additive modelling. Pregnant women (n=1138) were recruited for…

J Am Heart Assoc. 2025 Dec 23:e041805. doi: 10.1161/JAHA.124.041805. Online ahead of print. ABSTRACT BACKGROUND: Elevated childhood blood pressure (BP) levels may persist into adulthood, and persistent exposure to elevated BP since childhood may increase the adulthood risk of hypertension. This study examined the tracking of childhood BP into adulthood…

Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06635-9. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: In this prospective birth cohort study, we examined whether the dietary intake of A, B, C, D and E vitamins is associated with the risk of islet autoimmunity or type 1 diabetes in children who are genetically at…

Clin Endocrinol (Oxf). 2025 Dec 15. doi: 10.1111/cen.70070. Online ahead of print. ABSTRACT OBJECTIVE: Clinical autoimmune thyroid disease (AITD), presenting as either hypo- or hyperthyroidism, can occur at any age. Autoantibodies against thyroid peroxidase or thyroglobulin precede the onset of clinical AITD. We aimed to assess factors associated with AITD…

Diabetologia. 2025 Dec 8. doi: 10.1007/s00125-025-06613-1. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: The aetiology of type 1 diabetes remains elusive. Family history of type 1 diabetes increases the disease risk but the role of other autoimmune diseases or type 2 diabetes in the family are unclear. Here, we aimed to…

Eur J Ageing. 2025 Nov 29. doi: 10.1007/s10433-025-00896-4. Online ahead of print. ABSTRACT BACKGROUND: Behaviour-related health risk factors are associated with an increased risk of early exit from the working life, but their contribution to working life expectancy (WLE) remains unclear. We investigated the associations of obesity, alcohol intake, smoking…

Eur J Public Health. 2025 Nov 22:ckaf212. doi: 10.1093/eurpub/ckaf212. Online ahead of print. ABSTRACT Adolescent healthy behaviours may improve cardiometabolic health in adulthood differently across socioeconomic groups. We aimed to quantify the effects of adolescent healthy behaviours on multiple biomarkers of adult cardiometabolic health by socioeconomic backgrounds. We used a…

iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21. ABSTRACT Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This study investigates the gut metabolites, including short-chain fatty acids (SCFAs), bile acids (BAs), and…

Atherosclerosis. 2025 Nov 20;412:120595. doi: 10.1016/j.atherosclerosis.2025.120595. Online ahead of print. ABSTRACT BACKGROUNG AND AIMS: Inflammation is associated with cardiovascular disease development and microvascular dysfunction. The aim of the present study is to test the hypothesis that long-term exposure to chronic inflammation in childhood and adulthood is associated with adverse retinal…