Clin Endocrinol (Oxf). 2025 Oct 6. doi: 10.1111/cen.70039. Online ahead of print. ABSTRACT OBJECTIVE: In boys, constitutional delay of growth and puberty (CDGP) has been associated with diverse negative psychosocial effects. Albeit alleviating distress is one of the main reasons for inducing pubertal development, the impact of puberty-promoting treatment on…

Reproduction. 2025 Oct 3:REP-25-0297. doi: 10.1530/REP-25-0297. Online ahead of print. ABSTRACT IN BRIEF: Temporally regulated translation is critical for late steps of spermatogenesis due to transcriptional silencing during chromatin condensation. This study shows that the function of the cytoplasmic granule, the late chromatoid body, is connected to the translational regulation…

bioRxiv [Preprint]. 2025 Sep 16:2024.06.05.597641. doi: 10.1101/2024.06.05.597641. ABSTRACT Transit time, fluid intake, diet, and overall gut health all influence stool consistency. However, the relationships between the gut microbiota, metabolome (microbial metabolites), and stool consistency in infants and young children remain poorly understood. In this study, we analyzed the microbiota and…

Pediatr Diabetes. 2025 Sep 16;2025:8845330. doi: 10.1155/pedi/8845330. eCollection 2025. ABSTRACT Objective: To design a dynamic prediction model for estimating the time of progression from a single glutamic acid decarboxylase autoantibody (GADA) to multiple islet autoantibodies and type 1 diabetes in children, exploring different longitudinally measured risk variables. Research Design and…

Arthritis Rheumatol. 2025 Jul 16. doi: 10.1002/art.43315. Online ahead of print. ABSTRACT OBJECTIVE: Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive. METHODS: Plasma samples from 110…

J Commun Disord. 2025 Sep 4;118:106564. doi: 10.1016/j.jcomdis.2025.106564. Online ahead of print. ABSTRACT Studies have established that dimensions of temperament and language development are associated in childhood. Insofar, however, longitudinal studies from infancy into toddlerhood accounting for all temperament dimensions and covering preverbal communication in addition to emerging verbal skills…

J Pediatr. 2025 Sep 12:114782. doi: 10.1016/j.jpeds.2025.114782. Online ahead of print. NO ABSTRACT PMID:40946039 | DOI:10.1016/j.jpeds.2025.114782…

Environ Int. 2025 Sep 3;203:109779. doi: 10.1016/j.envint.2025.109779. Online ahead of print. ABSTRACT Polychlorinated biphenyls (PCBs) have been identified as diabetogens and potential epigenetic regulators. Epigenetic variation is implicated in the pathogenesis of type 2 diabetes (T2D) and is therefore a potential mechanism linking PCB exposure and T2D. We here investigate…

Mol Psychiatry. 2025 Sep 6. doi: 10.1038/s41380-025-03203-w. Online ahead of print. ABSTRACT Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual…

Eur Psychiatry. 2025 Sep 5:1-29. doi: 10.1192/j.eurpsy.2025.10097. Online ahead of print. NO ABSTRACT PMID:40908266 | DOI:10.1192/j.eurpsy.2025.10097…