Author: Henok Karvonen

J Hypertens. 2023 Jan 1;41(1):187-193. doi: 10.1097/HJH.0000000000003320. Epub 2022 Oct 27. ABSTRACT OBJECTIVES: Retirement is a major life event characterized by removal of work-related stressors and changes in health behaviours. The association between retirement and changes in blood pressure (BP), and particularly in ambulatory BP, has been scarcely studied. We…

Eur J Ageing. 2022 Nov 23;19(4):1587-1599. doi: 10.1007/s10433-022-00745-8. eCollection 2022 Dec. ABSTRACT Life satisfaction is an essential construct of well-being that is tied to behavioral, emotional, social and psychological outcomes. This study aimed to examine changes in total and domain-specific life satisfaction during the retirement transition and additionally examine whether…

Int J Environ Res Public Health. 2022 Nov 23;19(23):15567. doi: 10.3390/ijerph192315567. ABSTRACT Retirement poses opportunities and challenges for maintaining and adopting physically active habits, which may have major implications for health and functional ability in later life. Qualitative studies suggest that a broad range of meanings of physical activity should…

Horm Res Paediatr. 2022 Dec 7. doi: 10.1159/000528567. Online ahead of print. ABSTRACT INTRODUCTION: Newborn screening of congenital hypothyroidism (CH) has enabled early treatment with levothyroxine (LT4), ensuring normal growth and development. The initial LT4 dose recommendation has increased over decades. We evaluated whether the increased LT4 dosing influenced thyroid-stimulating…

Commun Med (Lond). 2023 Jan 18;3(1):4. doi: 10.1038/s43856-022-00226-0. ABSTRACT BACKGROUND: Testosterone levels are linked with diverse characteristics of human health, yet, whether these associations reflect correlation or causation remains debated. Here, we provide a broad perspective on the role of genetically determined testosterone on complex diseases in both sexes. METHODS:…

EJHaem. 2022 Sep 29;3(4):1188-1200. doi: 10.1002/jha2.588. eCollection 2022 Nov. ABSTRACT Cancer survivors show increased risk for non-communicable diseases and chronic low-grade inflammation characterizes the development of such diseases. We investigated inflammatory plasma protein profiles of survivors of childhood acute lymphoblastic leukemia (ALL) in comparison to healthy controls and after an…

Prog Neuropsychopharmacol Biol Psychiatry. 2023 Apr 20;123:110720. doi: 10.1016/j.pnpbp.2023.110720. Epub 2023 Jan 14. ABSTRACT Recent advances in genome-wide association studies have enabled the estimation of genetic risk of complex traits, including neuroticism, with polygenic risk scores (PRS). Neuroticism PRS has been associated with psychiatric disorders and symptoms in adults, but…

Endocrinology. 2022 Dec 19;164(2):bqac202. doi: 10.1210/endocr/bqac202. ABSTRACT Spermatogenesis is a complex differentiation process that takes place in the seminiferous tubules. A specific organization of spermatogenic cells within the seminiferous epithelium enables a synchronous progress of germ cells at certain steps of differentiation on the spermatogenic pathway. This can be observed…

Andrology. 2023 May;11(4):710-723. doi: 10.1111/andr.13361. Epub 2023 Jan 9. ABSTRACT BACKGROUND: Germ granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in meiotic spermatocytes and the chromatoid body (CB) in haploid round…

Sci Rep. 2022 Dec 2;12(1):20818. doi: 10.1038/s41598-022-25336-6. ABSTRACT While sunlight may influence cognitive function through several pathways, associations of residential sunlight exposure with cognitive function are not well known. We evaluated associations of long-term residential sunlight exposure with cognitive function among a representative cohort of 1838 Finnish adults residing in…