Mol Psychiatry. 2025 Apr 4. doi: 10.1038/s41380-025-02954-w. Online ahead of print. ABSTRACT Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration…
Author: Henok Karvonen
Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
Clin Epigenetics. 2025 Apr 2;17(1):55. doi: 10.1186/s13148-025-01860-w. ABSTRACT BACKGROUND: Sleep disturbances are known to have adverse effects on health, but knowledge on the effect of sleep disturbances on epigenetic ageing is limited. We investigated (1) whether symptoms of insomnia, obstructive sleep apnoea, sleep deprivation, and circadian rhythm lateness are associated…
Correction to “Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms”
Anal Chem. 2025 Apr 1. doi: 10.1021/acs.analchem.5c01621. Online ahead of print. NO ABSTRACT PMID:40167583 | DOI:10.1021/acs.analchem.5c01621…
Metabolic transition from childhood to adulthood based on two decades of biochemical time series in three longitudinal cohorts
Int J Epidemiol. 2025 Feb 16;54(2):dyaf026. doi: 10.1093/ije/dyaf026. ABSTRACT BACKGROUND: This is the first large-scale longitudinal study of children that describes the temporal trajectories of an extensive collection of metabolic measures that are relevant for lifelong cardiometabolic risk. We also provide a comprehensive picture on how metabolism develops into mature…
Blood pressure in childhood, young- and mid-adulthood: association with carotid plaque severity
Eur Heart J. 2025 Mar 25:ehaf139. doi: 10.1093/eurheartj/ehaf139. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Blood pressure (BP) is a key modifiable risk factor for atherosclerosis. How BP across different life stages associates with carotid plaque in mid-adulthood remains unclear, which is the aim of this study. METHODS: The…
Incidence of new onset arterial hypertension after metabolic bariatric surgery: an 8-year prospective follow-up with matched controls
J Hypertens. 2025 Feb 24. doi: 10.1097/HJH.0000000000003993. Online ahead of print. ABSTRACT BACKGROUND: Metabolic bariatric surgery (MBS) reduces the risk of new-onset hypertension; however, it is unclear whether this effect varies according to patient sex, age, or socioeconomic background. This study aimed to assess the risk of new-onset arterial hypertension…
Association of Paternal BMI and Diet During Pregnancy with Offspring Birth Measures: The STEPS Study
Nutrients. 2025 Feb 28;17(5):866. doi: 10.3390/nu17050866. ABSTRACT BACKGROUND/OBJECTIVES: Maternal Body Mass Index (BMI), diet quality, and their associated effects on offspring birth measures are well-established. Emerging evidence, largely from animal studies, has indicated paternal factors can influence offspring birth outcomes. However, this effect is poorly understood in humans. Our aim…
Association of neighbourhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study
Am J Epidemiol. 2025 Mar 7:kwaf032. doi: 10.1093/aje/kwaf032. Online ahead of print. ABSTRACT Socioeconomic disadvantage at individual level is associated with poor cognitive outcomes but the link of neighbourhood disadvantage with cognitive function is unclear. We used data from Young Finns Study, a population-based cohort, to examine the associations of…
The association of childhood HDL cholesterol with atherosclerotic CVD events in adults: findings from the International Childhood Cardiovascular Cohort Consortium
Eur J Prev Cardiol. 2025 Mar 5:zwaf117. doi: 10.1093/eurjpc/zwaf117. Online ahead of print. ABSTRACT AIMS: The role of adult HDL-C in atherosclerotic cardiovascular disease (ASCVD) faces challenges from Mendelian randomisations and drug trials. However, the association between childhood HDL-C and its changes and adult ASCVD remains undefined. This study aimed…
A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations
Res Sq [Preprint]. 2025 Feb 17:rs.3.rs-6025759. doi: 10.21203/rs.3.rs-6025759/v1. ABSTRACT Background Gene-environment interactions may enhance our understanding of hypertension. Our previous study highlighted the importance of considering psychosocial factors in gene discovery for blood pressure (BP) but was limited in statistical power and population diversity. To address these challenges, we conducted…
