medRxiv [Preprint]. 2024 Jun 25:2024.06.23.24309353. doi: 10.1101/2024.06.23.24309353. ABSTRACT Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain…
Publications
Publications
Temporal Alterations in CD8+ T Cells During the Progression from Stage 1 to Stage 3 Type 1 Diabetes
Diabetes. 2024 Jul 5:db240159. doi: 10.2337/db24-0159. Online ahead of print. ABSTRACT CD8+ T cells are perceived to play a major role in the pathogenesis of type 1 diabetes (T1D). In this study, we characterized the function and phenotype of circulating CD8+ memory T cells in samples from individuals at different…
Implementing ABCD studyⓇ MRI sequences for multi-site cohort studies: Practical guide to necessary steps, preprocessing methods, and challenges
MethodsX. 2024 Jun 1;12:102789. doi: 10.1016/j.mex.2024.102789. eCollection 2024 Jun. ABSTRACT Large multi-site studies that combine magnetic resonance imaging (MRI) data across research sites present exceptional opportunities to advance neuroscience research. However, scanner or site variability and non-standardised image acquisition protocols, data processing and analysis pipelines can adversely affect the reliability…
Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth
Cell Rep. 2024 Jul 3;43(7):114430. doi: 10.1016/j.celrep.2024.114430. Online ahead of print. ABSTRACT Cancer cells undergo major epigenetic alterations and transcriptomic changes, including ectopic expression of tissue- and cell-type-specific genes. Here, we show that the germline-specific RNA helicase DDX4 forms germ-granule-like cytoplasmic ribonucleoprotein granules in various human tumors, but not in…
Editorial: Update on epidemiology, endocrinology and treatment of cryptorchidism
Front Endocrinol (Lausanne). 2024 Jun 10;15:1435877. doi: 10.3389/fendo.2024.1435877. eCollection 2024. NO ABSTRACT PMID:38915895 | PMC:PMC11194432 | DOI:10.3389/fendo.2024.1435877…
Cardiovascular Risk Factors in Childhood and Adulthood and Cardiovascular Disease in Middle Age
JAMA Netw Open. 2024 Jun 3;7(6):e2418148. doi: 10.1001/jamanetworkopen.2024.18148. ABSTRACT IMPORTANCE: Recent evidence suggests that childhood levels of serum lipids, blood pressure, body mass index (BMI), and smoking contribute to adult risk of cardiovascular disease (CVD). Evidence is lacking on whether this is independent of adult risk levels. OBJECTIVE: To quantify…
Association of Serum Trimethylamine-N-Oxide Concentration from Childhood to Early Adulthood with Age and Sex
Clin Chem. 2024 Jun 22:hvae087. doi: 10.1093/clinchem/hvae087. Online ahead of print. ABSTRACT BACKGROUND: Primary prevention is the cornerstone of cardiometabolic health. In the randomized, controlled Special Turku Coronary Risk Factor Intervention Project (STRIP), dietary counseling intervention was given to children from infancy to 20 years of age and a follow-up…
Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child
Clin Nutr ESPEN. 2024 Aug;62:22-27. doi: 10.1016/j.clnesp.2024.05.001. Epub 2024 May 11. ABSTRACT BACKGROUND & AIMS: Maternal gluten intake in relation to child’s risk of type 1 diabetes has been studied in few prospective studies considering the diet during pregnancy but none during lactation. Our aim was to study whether gluten,…
The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study
J Endocr Soc. 2024 May 24;8(7):bvae103. doi: 10.1210/jendso/bvae103. eCollection 2024 May 23. ABSTRACT CONTEXT: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty. OBJECTIVE: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes. METHODS: The relationships between puberty, islet…
Change in cognitive performance during seven-year follow-up in midlife is associated with sex, age, and education – The Cardiovascular Risk in Young Finns Study
J Neurol. 2024 Jun 2. doi: 10.1007/s00415-024-12466-2. Online ahead of print. ABSTRACT OBJECTIVE: Sex, age, and education are associated with the level of cognitive performance. We investigated whether these factors modulate the change in cognitive performance in midlife by leveraging the longitudinal data from the Cardiovascular Risk in Young Finns…
