Int J Obes (Lond). 2024 Jan 25. doi: 10.1038/s41366-024-01466-x. Online ahead of print. ABSTRACT BACKGROUND: Metabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors remains unclear. METHODS: Two independent discovery cohorts, consisting of twins and unrelated individuals, were examined (N…
Publications
Publications
Negative associations between maternal prenatal hair cortisol and child socioemotional problems
Psychoneuroendocrinology. 2024 Jan 4;162:106955. doi: 10.1016/j.psyneuen.2023.106955. Online ahead of print. ABSTRACT Maternal prenatal distress can participate in the programming of offspring development, in which exposure to altered maternal long-term cortisol levels as measured by hair cortisol concentrations (HCC) may contribute. Yet, studies investigating whether and how maternal prenatal HCC associates…
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
Nat Commun. 2024 Jan 18;15(1):586. doi: 10.1038/s41467-024-44709-1. ABSTRACT X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the…
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Genome Biol. 2024 Jan 16;25(1):22. doi: 10.1186/s13059-023-03136-z. ABSTRACT BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated…
Association of long-term habitual dietary fiber intake since infancy with gut microbiota composition in young adulthood
J Nutr. 2024 Jan 12:S0022-3166(24)00027-0. doi: 10.1016/j.tjnut.2024.01.008. Online ahead of print. ABSTRACT BACKGROUND: Dietary fiber is an important health-promoting component of the diet, which is fermented by the gut microbes that produce metabolites beneficial for the host’s health. OBJECTIVE: We studied the associations of habitual long-term fiber intake from infancy…
Polygenic risk for depression predicting temperament trajectories over 15 years – A general population study
J Affect Disord. 2024 Jan 11:S0165-0327(24)00103-4. doi: 10.1016/j.jad.2024.01.093. Online ahead of print. ABSTRACT BACKGROUND: A great number of case-control and population-based studies have shown that depression patients differ from healthy controls in their temperament traits. We investigated whether polygenic risk for depression predicts trajectories of temperament traits from early adulthood…
Trajectories of maternal depressive and anxiety symptoms and child’s socio-emotional outcome during early childhood
J Affect Disord. 2024 Jan 4:S0165-0327(23)01544-6. doi: 10.1016/j.jad.2023.12.076. Online ahead of print. ABSTRACT Maternal symptoms of depression and anxiety during pregnancy and early postnatal years are suggested to impose differential negative effects on child’s socio-emotional development depending on the characteristics of the symptoms, such as timing, intensity, and persistence. The…
Climate Change, Summer Temperature, and Heat-Related Mortality in Finland: Multicohort Study with Projections for a Sustainable vs. Fossil-Fueled Future to 2050
Environ Health Perspect. 2023 Dec;131(12):127020. doi: 10.1289/EHP12080. Epub 2023 Dec 27. ABSTRACT BACKGROUND: Climate change scenarios illustrate various pathways in terms of global warming ranging from “sustainable development” (Shared Socioeconomic Pathway SSP1-1.9), the best-case scenario, to ‘fossil-fueled development’ (SSP5-8.5), the worst-case scenario. OBJECTIVES: We examined the extent to which increase…
Fruit, berry, and vegetable consumption and the risk of islet autoimmunity and type 1 diabetes in children – The DIPP birth cohort study
Am J Clin Nutr. 2023 Dec 22:S0002-9165(23)66347-6. doi: 10.1016/j.ajcnut.2023.12.014. Online ahead of print. ABSTRACT BACKGROUND: Prospective studies investigating the association between fruit, berry, and vegetable consumption and the risk of islet autoimmunity (IA) and type 1 diabetes (T1D) are few. OBJECTIVE: In this cohort study, we explored whether the consumption…
Association of number of siblings with preclinical markers of cardiovascular disease. The cardiovascular risk in Young Finns study
Int J Cardiol Cardiovasc Risk Prev. 2023 Dec 8;20:200227. doi: 10.1016/j.ijcrp.2023.200227. eCollection 2024 Mar. ABSTRACT To investigate the association of number of siblings with preclinical cardiovascular disease (CVD) markers in adulthood. The sample comprised 2776 participants (54 % female) from the Cardiovascular Risk in Young Finns Study who had CVD…
