Publications

J Am Coll Cardiol. 2024 May 28;83(21):2112-2127. doi: 10.1016/j.jacc.2024.02.053. ABSTRACT Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide and challenges the capacity of health care systems globally. Atherosclerosis is the underlying pathophysiological entity in two-thirds of patients with CVD. When considering that atherosclerosis develops over decades,…

Genome Biol. 2024 May 21;25(1):129. doi: 10.1186/s13059-024-03276-w. NO ABSTRACT PMID:38773652 | DOI:10.1186/s13059-024-03276-w…

Front Psychiatry. 2024 Apr 25;15:1345159. doi: 10.3389/fpsyt.2024.1345159. eCollection 2024. ABSTRACT BACKGROUND: Studies have shown that cardiovascular health (CVH) is related to depression. We aimed to identify gene networks jointly associated with depressive symptoms and cardiovascular health metrics using the whole blood transcriptome. MATERIALS AND METHODS: We analyzed human blood transcriptomic…

Nat Commun. 2024 May 7;15(1):3810. doi: 10.1038/s41467-024-47918-w. ABSTRACT Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes in children who develop islet-specific antibodies either to insulin (IAA) or glutamic acid decarboxylase (GADA) as the first autoantibodies. Here, we test the hypothesis that children who later develop…

J Phys Act Health. 2024 May 2:1-9. doi: 10.1123/jpah.2023-0558. Online ahead of print. ABSTRACT BACKGROUND: Retirement transition has been shown to associate with changes in physical activity (PA) and self-rated health (SRH), but their interrelationship is less studied. The aim was to investigate changes in accelerometer-measured total PA, moderate to…

Biosci Rep. 2024 May 3:BSR20240562. doi: 10.1042/BSR20240562. Online ahead of print. ABSTRACT Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is associated with increased risk of neurodevelopmental disorders in exposed offspring. The pathophysiological mechanisms mediating this relationship are currently unknown, and one potential candidate is the anti-angiogenic factor soluble…

BMC Med Inform Decis Mak. 2024 May 2;24(1):116. doi: 10.1186/s12911-024-02521-3. ABSTRACT BACKGROUND: Machine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics data, although these outcomes often exhibit categorical nature and class imbalances. However, little is known about which ML classifier, omics…

Nat Genet. 2024 Apr 30. doi: 10.1038/s41588-024-01714-w. Online ahead of print. ABSTRACT Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to…

Br J Surg. 2024 Apr 3;111(4):znae105. doi: 10.1093/bjs/znae105. ABSTRACT BACKGROUND: Metabolic bariatric surgery the reduces risk of new-onset type 2 diabetes in individuals with obesity, but it is unclear whether the benefit varies by sex, age, or socioeconomic status. The aim was to assess the risk of new-onset type 2…

Lancet Microbe. 2024 Apr 25:S2666-5247(24)00038-7. doi: 10.1016/S2666-5247(24)00038-7. Online ahead of print. ABSTRACT BACKGROUND: Group B streptococcus is a major cause of neonatal disease. Natural history studies have linked maternally transferred anti-group B streptococcus capsular polysaccharide antibodies with protection against infant group B streptococcus disease. Previous studies of capsular polysaccharide antibody…