Psychol Med. 2023 Dec 4:1-9. doi: 10.1017/S003329172300346X. Online ahead of print. ABSTRACT BACKGROUND: We investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRSSCZ-specific or evident also for any polygenic risk for mental…
Publications
Publications
Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk
Am J Clin Nutr. 2023 Dec;118(6):1099-1105. doi: 10.1016/j.ajcnut.2023.08.009. Epub 2023 Oct 16. ABSTRACT BACKGROUND: Higher gluten intake in childhood is associated with increased incidence of celiac disease autoimmunity (CDA) and celiac disease. It remains to be studied whether different dietary patterns independent of gluten intake contribute to the incidence. OBJECTIVES:…
Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study
Aging Cell. 2023 Nov 29:e14052. doi: 10.1111/acel.14052. Online ahead of print. ABSTRACT Schizophrenia is often regarded as a disorder of premature aging. We investigated (a) whether polygenic risk for schizophrenia (PRSsch ) relates to pace of epigenetic aging and (b) whether personal dispositions toward active and emotionally close relationships protect…
Clinical and biochemical associations of urinary metabolites: quantitative epidemiological approach on renal-cardiometabolic biomarkers
Int J Epidemiol. 2023 Nov 29:dyad162. doi: 10.1093/ije/dyad162. Online ahead of print. ABSTRACT BACKGROUND: Urinary metabolomics has demonstrated considerable potential to assess kidney function and its metabolic corollaries in health and disease. However, applications in epidemiology remain sparse due to technical challenges. METHODS: We added 17 metabolites to an open-access…
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
Front Genet. 2023 Nov 2;14:1235337. doi: 10.3389/fgene.2023.1235337. eCollection 2023. ABSTRACT Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was…
CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity
Front Genet. 2023 Nov 2;14:1248701. doi: 10.3389/fgene.2023.1248701. eCollection 2023. ABSTRACT Enteroviral infections have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D), and the coxsackie and adenovirus receptor (CXADR) is one of the ligands used by adenoviruses and enteroviruses for cell internalization. Two CXADR single…
Metformin Versus Insulin for Gestational Diabetes: Cognitive and Neuropsychological Profiles of Children Aged 9 years
J Dev Behav Pediatr. 2023 Dec 1;44(9):e642-e650. doi: 10.1097/DBP.0000000000001233. Epub 2023 Nov 28. ABSTRACT OBJECTIVE: We compared cognitive profile and neuropsychological performance in 9-year-old offspring of mothers who were treated with metformin or insulin for gestational diabetes mellitus (GDM). METHODS: A total of 172 children whose mothers were randomly assigned…
Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events
Circulation. 2023 Nov 28. doi: 10.1161/CIRCULATIONAHA.123.064296. Online ahead of print. ABSTRACT BACKGROUND: Although low-density lipoprotein cholesterol (LDL-C) remains the primary cholesterol target in clinical practice in children and adults, non-high-density lipoprotein cholesterol (non-HDL-C) has been suggested as a more accurate measure of atherosclerotic cardiovascular disease (ASCVD) risk. We examined the…
Across ages and places: Unpredictability of maternal sensory signals and child internalizing behaviors
J Affect Disord. 2023 Nov 23:S0165-0327(23)01437-4. doi: 10.1016/j.jad.2023.11.068. Online ahead of print. ABSTRACT BACKGROUND: Patterns of sensory inputs early in life play an integral role in shaping the maturation of neural circuits, including those implicated in emotion and cognition. In both experimental animal models and observational human research, unpredictable sensory…
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection
Nat Commun. 2023 Nov 22;14(1):7630. doi: 10.1038/s41467-023-42763-9. ABSTRACT Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children…
