J Pediatr. 2023 Oct 13:113776. doi: 10.1016/j.jpeds.2023.113776. Online ahead of print. ABSTRACT This 26-year study found that non-high-density lipoprotein cholesterol (non-HDL-C) levels tracked from infancy to young adulthood, suggesting early-life non-HDL-C could predict future levels. However, infancy-onset dietary counseling reduced the odds of maintaining at-risk non-HDL-C, highlighting the potential importance…
Publications
Publications
Childhood maltreatment, trait resilience and prenatal distress among expecting mothers and fathers in the FinnBrain Birth Cohort Study
J Affect Disord. 2023 Oct 9:S0165-0327(23)01223-5. doi: 10.1016/j.jad.2023.10.026. Online ahead of print. ABSTRACT BACKGROUND: In this study we examined the association between childhood maltreatment exposure (CME) and psychological distress, including symptoms of depression and anxiety, during pregnancy. Additionally, we explored the potential moderating effect of trait resilience on these associations.
Physical activity and self-rated health during retirement transition: a multitrajectory analysis of concurrent changes among public sector employees
BMJ Open. 2023 Sep 29;13(9):e073876. doi: 10.1136/bmjopen-2023-073876. ABSTRACT OBJECTIVES: The aim of the study was to evaluate concurrent changes in physical activity and self-rated health during retirement transition over 4 years by multivariate trajectory analysis and to examine whether sociodemographic and lifestyle factors predict the probability of being classified to…
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification
Nat Genet. 2023 Sep 28. doi: 10.1038/s41588-023-01518-4. Online ahead of print. ABSTRACT Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only four known risk loci…
A proposed pediatric clinical cardiovascular health reference standard
Am J Prev Med. 2023 Sep 24:S0749-3797(23)00382-3. doi: 10.1016/j.amepre.2023.09.019. Online ahead of print. ABSTRACT INTRODUCTION: Clinical cardiovascular health (CVH) is a construct that includes four health factors – systolic and diastolic blood pressure (BP), fasting glucose, total cholesterol, and body mass index [BMI] – which together provide an evidence-based, more…
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Nat Genet. 2023 Sep 25. doi: 10.1038/s41588-023-01531-7. Online ahead of print. NO ABSTRACT PMID:37749248 | DOI:10.1038/s41588-023-01531-7…
Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children
Front Endocrinol (Lausanne). 2023 Sep 6;14:1211015. doi: 10.3389/fendo.2023.1211015. eCollection 2023. ABSTRACT AIMS/HYPOTHESIS: Appearance of multiple islet cell autoantibodies in early life is indicative of future progression to overt type 1 diabetes, however, at varying rates. Here, we aimed to study whether distinct metabolic patterns could be identified in rapid progressors…
Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
Sci Rep. 2023 Sep 24;13(1):15941. doi: 10.1038/s41598-023-43039-4. ABSTRACT Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging process. To address this concern, we used…
Attention biases for emotional facial expressions during a free viewing task increase between 2.5 and 5 years of age
Dev Psychol. 2023 Sep 21. doi: 10.1037/dev0001598. Online ahead of print. ABSTRACT The normative, developmental changes in affect-biased attention during the preschool years are largely unknown. To investigate the attention bias for emotional versus neutral faces, an eye-tracking measurement and free viewing of paired pictures of facial expressions (i.e., happy,…
DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls
Autoimmunity. 2023 Dec;56(1):2259118. doi: 10.1080/08916934.2023.2259118. Epub 2023 Sep 19. ABSTRACT We elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters in different lymphocyte…
