BMJ Open. 2023 Dec 10;13(12):e076976. doi: 10.1136/bmjopen-2023-076976. ABSTRACT PURPOSE: The Finnish Retirement and Aging (FIREA) Study was set up to study changes in health behavioural and cardiometabolic risk factors across retirement transition, and to examine the long-term consequences of work and retirement on health and functioning with advancing age. PARTICIPANTS:…
Publications
Publications
Sense of coherence, its components and depressive and anxiety symptoms in expecting women and their partners – A FinnBrain Birth Cohort Study
Sex Reprod Healthc. 2023 Nov 24;39:100930. doi: 10.1016/j.srhc.2023.100930. Online ahead of print. ABSTRACT OBJECTIVE: Expecting mothers with high sense of coherence (SOC) exhibit improved physical, emotional, and childbearing health. However, the dimensions of SOC and the factor structure of the SOC-13 scale during prenatal period is slightly known. Especially the…
Tracking of apolipoprotein B levels measured in childhood and adolescence: systematic review and meta-analysis
Eur J Pediatr. 2023 Dec 5. doi: 10.1007/s00431-023-05350-0. Online ahead of print. ABSTRACT To quantify the tracking of apolipoprotein B (apoB) levels from childhood and adolescence and compare the tracking of apoB with low-density lipoprotein (LDL) cholesterol, a systematic search of MEDLINE, Embase, Web of Science, and Google Scholar was…
Blood Pressure at Different Life Stages Over the Early Life Course and Intima-Media Thickness
JAMA Pediatr. 2023 Dec 4. doi: 10.1001/jamapediatrics.2023.5351. Online ahead of print. ABSTRACT IMPORTANCE: Although cardiovascular disease (CVD) begins in early life, the extent to which blood pressure (BP) at different life stages contributes to CVD is unclear. OBJECTIVE: To determine the relative contribution of BP at different life stages across…
Polygenic risk for schizophrenia predicting social trajectories in a general population sample
Psychol Med. 2023 Dec 4:1-9. doi: 10.1017/S003329172300346X. Online ahead of print. ABSTRACT BACKGROUND: We investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRSSCZ-specific or evident also for any polygenic risk for mental…
Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk
Am J Clin Nutr. 2023 Dec;118(6):1099-1105. doi: 10.1016/j.ajcnut.2023.08.009. Epub 2023 Oct 16. ABSTRACT BACKGROUND: Higher gluten intake in childhood is associated with increased incidence of celiac disease autoimmunity (CDA) and celiac disease. It remains to be studied whether different dietary patterns independent of gluten intake contribute to the incidence. OBJECTIVES:…
Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study
Aging Cell. 2023 Nov 29:e14052. doi: 10.1111/acel.14052. Online ahead of print. ABSTRACT Schizophrenia is often regarded as a disorder of premature aging. We investigated (a) whether polygenic risk for schizophrenia (PRSsch ) relates to pace of epigenetic aging and (b) whether personal dispositions toward active and emotionally close relationships protect…
Clinical and biochemical associations of urinary metabolites: quantitative epidemiological approach on renal-cardiometabolic biomarkers
Int J Epidemiol. 2023 Nov 29:dyad162. doi: 10.1093/ije/dyad162. Online ahead of print. ABSTRACT BACKGROUND: Urinary metabolomics has demonstrated considerable potential to assess kidney function and its metabolic corollaries in health and disease. However, applications in epidemiology remain sparse due to technical challenges. METHODS: We added 17 metabolites to an open-access…
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
Front Genet. 2023 Nov 2;14:1235337. doi: 10.3389/fgene.2023.1235337. eCollection 2023. ABSTRACT Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was…
CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity
Front Genet. 2023 Nov 2;14:1248701. doi: 10.3389/fgene.2023.1248701. eCollection 2023. ABSTRACT Enteroviral infections have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D), and the coxsackie and adenovirus receptor (CXADR) is one of the ligands used by adenoviruses and enteroviruses for cell internalization. Two CXADR single…
