Association of childhood socioeconomic status with adulthood maximal exercise blood pressure: the Cardiovascular Risk in Young Finns Study

Blood Press. 2024 Dec;33(1):2323987. doi: 10.1080/08037051.2024.2323987. Epub 2024 Mar 11. ABSTRACT PURPOSE: Socioeconomic status has been related to resting blood pressure (BP) levels at different stages of life. However, the association of childhood socioeconomic status (SES) and adulthood exercise BP is largely unknown. Therefore, we studied the association of childhood…

Genome-wide characterization of circulating metabolic biomarkers

Nature. 2024 Mar 6. doi: 10.1038/s41586-024-07148-y. Online ahead of print. ABSTRACT Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms…

Intergenerational continuity of loneliness and potential mechanisms: Young Finns Multigenerational Study

Sci Rep. 2024 Mar 5;14(1):5465. doi: 10.1038/s41598-024-56147-6. ABSTRACT Evidence on the intergenerational continuity of loneliness and on potential mechanisms that connect loneliness across successive generations is limited. We examined the association between loneliness of (G0) parents (859 mothers and 570 fathers, mean age 74 years) and their children (G1) (433…

A healthy lifestyle can support future sexual satisfaction: results from a 9-year longitudinal survey

J Sex Med. 2024 Mar 5:qdae009. doi: 10.1093/jsxmed/qdae009. Online ahead of print. ABSTRACT BACKGROUND: Previous follow-up studies have demonstrated the association between good health behavior and good sexual functioning for men, but the longitudinal relationship between multiple health behaviors and satisfaction with sex life remains understudied. AIM: The aim of…

Gene expression networks regulated by human personality

Mol Psychiatry. 2024 Mar 4. doi: 10.1038/s41380-024-02484-x. Online ahead of print. ABSTRACT Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to personality in humans. We collected genome-wide expression profiles of adults to characterize the regulation of…

Longitudinal Associations between 24-H Movement Behaviors and Cardiometabolic Biomarkers: A Natural Experiment over Retirement

Med Sci Sports Exerc. 2024 Feb 29. doi: 10.1249/MSS.0000000000003415. Online ahead of print. ABSTRACT INTRODUCTION: Physical activity, sedentary behavior and sleep, that is, 24-h movement behaviors, often change in the transition from work to retirement, which may affect cardiometabolic health. This study investigates the longitudinal associations between changes in 24-h…

Effect of weight on depression using multiple genetic instruments

PLoS One. 2024 Feb 23;19(2):e0297594. doi: 10.1371/journal.pone.0297594. eCollection 2024. ABSTRACT A striking global health development over the past few decades has been the increasing prevalence of overweight and obesity. At the same time, depression has become increasingly common in almost all high-income countries. We investigated whether body weight, measured by…

Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes

Diabetes Metab Res Rev. 2024 Feb;40(2):e3777. doi: 10.1002/dmrr.3777. ABSTRACT BACKGROUND/AIM: Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic…

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