Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring

Am J Psychiatry. 2023 Sep 6:appiajp21111176. doi: 10.1176/appi.ajp.21111176. Online ahead of print. ABSTRACT OBJECTIVE: Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in infancy. This…

Trajectories of COVID-19 pandemic-related depressive symptoms and potential predictors: the FinnBrain Birth Cohort Study

Soc Psychiatry Psychiatr Epidemiol. 2023 Sep 5. doi: 10.1007/s00127-023-02559-0. Online ahead of print. ABSTRACT PURPOSE: In the context of the COVID-19 pandemic, mental health problems have been reported, and parents of young children may be more vulnerable to psychological distress due to increased caregiving responsibilities. However, research on the heterogeneity…

Association of Tobacco Smoke Exposure with Metabolic Profile from Childhood to Early Adulthood. The Special Turku Coronary Risk Factor Intervention Project (STRIP)

Eur J Prev Cardiol. 2023 Sep 1:zwad285. doi: 10.1093/eurjpc/zwad285. Online ahead of print. ABSTRACT AIMS: To investigate the associations between passive tobacco smoke exposure and daily smoking with a comprehensive metabolic profile, measured repeatedly from childhood to adulthood. METHODS: Study cohort was derived from the Special Turku Coronary Risk Factor…

Effect of number of diffusion encoding directions in neonatal diffusion tensor imaging using Tract-Based Spatial Statistical analysis

Eur J Neurosci. 2023 Aug 29. doi: 10.1111/ejn.16135. Online ahead of print. ABSTRACT Diffusion tensor imaging (DTI) has been used to study the developing brain in early childhood, infants and in utero studies. In infants, number of used diffusion encoding directions has traditionally been smaller in earlier studies down to…

Do sleep problems explain the association between work stress and the trajectories of work ability from midlife to pensionable age?

J Occup Environ Med. 2023 Aug 28. doi: 10.1097/JOM.0000000000002954. Online ahead of print. ABSTRACT OBJECTIVE: This study examined whether mid-life work stress, defined as job strain and effort-reward imbalance (ERI), predicts work ability trajectories observed 12 years preceding the individual pensionable age. Additionally, the role of sleep problems as a…

Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort

Pediatr Diabetes. 2023;2023:3945064. doi: 10.1155/2023/3945064. Epub 2023 Feb 17. ABSTRACT BACKGROUND/OBJECTIVE: Growth and obesity have been associated with increased risk of islet autoimmunity (IA) and progression to type 1 diabetes. We aimed to estimate the effect of energy-yielding macronutrient intake on the development of IA through BMI. RESEARCH DESIGN AND…

Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study

Diabetes Care. 2023 Aug 22:dc230518. doi: 10.2337/dc23-0518. Online ahead of print. ABSTRACT OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort. RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin…

Structural brain correlates of non-verbal cognitive ability in 5-year-old children: Findings from the FinnBrain birth cohort study

Hum Brain Mapp. 2023 Aug 22. doi: 10.1002/hbm.26463. Online ahead of print. ABSTRACT Non-verbal cognitive ability predicts multiple important life outcomes, for example, school and job performance. It has been associated with parieto-frontal cortical anatomy in prior studies in adult and adolescent populations, while young children have received relatively little…

HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study

Diabetes Care. 2023 Aug 14:dc230417. doi: 10.2337/dc23-0417. Online ahead of print. ABSTRACT OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic…

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