Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Nat Genet. 2024 Apr 30. doi: 10.1038/s41588-024-01714-w. Online ahead of print. ABSTRACT Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to…

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Association between anti-capsular IgG levels at birth and risk of invasive group B streptococcus disease in Finnish newborns: a retrospective case-control study

Lancet Microbe. 2024 Apr 25:S2666-5247(24)00038-7. doi: 10.1016/S2666-5247(24)00038-7. Online ahead of print. ABSTRACT BACKGROUND: Group B streptococcus is a major cause of neonatal disease. Natural history studies have linked maternally transferred anti-group B streptococcus capsular polysaccharide antibodies with protection against infant group B streptococcus disease. Previous studies of capsular polysaccharide antibody…

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Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: Cardiovascular Risk in Young Finns Study

Cancer Epidemiol Biomarkers Prev. 2024 Apr 19. doi: 10.1158/1055-9965.EPI-23-1000. Online ahead of print. ABSTRACT BACKGROUND: Lifestyle factors may affect cancer risk. This study aimed to identify whether American Heart Association (AHA) Ideal Cardiovascular Health (ICH) score and its individual variables in youth associate with subsequent cancer incidence. METHODS: Study comprised…

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Mother-Infant Interaction and Maternal Postnatal Psychological Distress Associate with Child’s Social-Emotional Development During Early Childhood: A FinnBrain Birth Cohort Study

Child Psychiatry Hum Dev. 2024 Apr 16. doi: 10.1007/s10578-024-01694-2. Online ahead of print. ABSTRACT We studied the effects of mother-infant interaction and maternal pre- and postnatal psychological distress on children’s social-emotional problems and competences, as well as whether interaction quality moderates the association between distress and children’s outcomes. Maternal pre-…

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Non-High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events

JAMA. 2024 Apr 12. doi: 10.1001/jama.2024.4819. Online ahead of print. ABSTRACT IMPORTANCE: Elevated non-high-density lipoprotein cholesterol (non-HDL-C; a recommended measure of lipid-related cardiovascular risk) is common in children and increases risk of adult cardiovascular disease (CVD). Whether resolution of elevated childhood non-HDL-C levels by adulthood is associated with reduced risk…

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Subclinical atherosclerosis in young adults predicting cardiovascular disease: The Cardiovascular Risk in Young Finns Study

Atherosclerosis. 2024 Mar 19:117515. doi: 10.1016/j.atherosclerosis.2024.117515. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Atherosclerosis is accompanied by pre-clinical vascular changes that can be detected using ultrasound imaging. We examined the value of such pre-clinical features in identifying young adults who are at risk of developing atherosclerotic cardiovascular disease (ASCVD).

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