Eur J Nutr. 2023 Mar;62(2):847-856. doi: 10.1007/s00394-022-03035-2. Epub 2022 Oct 25. ABSTRACT PURPOSE: The aim was to study the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D). METHODS: The prospective Finnish Type 1 Diabetes Prediction and Prevention (DIPP)…
Publications
Publications
SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis
Nucleic Acids Res. 2022 Nov 11;50(20):11470-11491. doi: 10.1093/nar/gkac900. ABSTRACT Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice. Germ-cell conditional knockout (cKO) of Smg6 induces extensive…
Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis: Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study
Atherosclerosis. 2022 Nov;361:1-9. doi: 10.1016/j.atherosclerosis.2022.10.005. Epub 2022 Oct 8. ABSTRACT AIM: We aimed at identifying the shared biological processes underlying atherosclerosis-osteoporosis co/multimorbidity. METHODS: We performed gene set analysis (GSA) of whole-blood transcriptomic data to identify biological processes shared by the early markers of these two diseases. Early markers of diseases,…
Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts
Dev Psychopathol. 2021 Dec;33(5):1837-1848. doi: 10.1017/s0954579421001012. Epub 2021 Oct 15. ABSTRACT High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research…
Multi-trajectory analysis of changes in physical activity and body mass index in relation to retirement: Finnish Retirement and Aging study
PLoS One. 2022 Dec 1;17(12):e0278405. doi: 10.1371/journal.pone.0278405. eCollection 2022. ABSTRACT BACKGROUND: Physical activity and body mass index (BMI) have been reported to change around retirement. The objective was to examine the concurrent changes in physical activity and BMI around retirement, which have not been studied before. In addition, the associations…
A saturated map of common genetic variants associated with human height
Nature. 2022 Oct;610(7933):704-712. doi: 10.1038/s41586-022-05275-y. Epub 2022 Oct 12. ABSTRACT Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals…
Lipoprotein(a) in Youth and Prediction of Major Cardiovascular Outcomes in Adulthood
Circulation. 2023 Jan 3;147(1):23-31. doi: 10.1161/CIRCULATIONAHA.122.060667. Epub 2022 Nov 28. ABSTRACT BACKGROUND: Elevated lipoprotein(a) [Lp(a)] is a common risk factor for cardiovascular disease outcomes with unknown mechanisms. We examined its potential role in identifying youths who are at increased risk of developing adult atherosclerotic cardiovascular disease (ASCVD). METHODS: Lp(a) levels…
Metabolic trajectories in childhood and adolescence: Effects on risk for schizophrenia
Schizophrenia (Heidelb). 2022 Oct 11;8(1):82. doi: 10.1038/s41537-022-00282-4. ABSTRACT Abnormal glucose and lipid metabolism is common in antipsychotic-naive first-episode patients with schizophrenia, but it is unclear whether these changes can already be seen in premorbid or prodromal period, before the first psychotic episode. We examined insulin, total cholesterol, low-density lipoprotein (LDL)…
Parental Self-Efficacy and Child Diet Quality between Ages 2 and 5: The STEPS Study
Nutrients. 2022 Nov 18;14(22):4891. doi: 10.3390/nu14224891. ABSTRACT Parental self-efficacy (PSE), a measure of the subjective competence in the parental role, has been linked with child well-being and health. Research on the influence of PSE on child eating habits is scarce, and the few studies have concentrated on certain food groups,…
Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias
Chemosphere. 2023 Feb;313:137343. doi: 10.1016/j.chemosphere.2022.137343. Epub 2022 Nov 21. ABSTRACT Hypospadias is a congenital malformation of penile urethra with unknown etiology in most cases. Persistent organic pollutant (POP) exposure may disrupt endocrine function during a critical window of development of male genitalia. In animal studies, POPs have been associated with…
