Publications

iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21. ABSTRACT Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This study investigates the gut metabolites, including short-chain fatty acids (SCFAs), bile acids (BAs), and…

Atherosclerosis. 2025 Nov 20;412:120595. doi: 10.1016/j.atherosclerosis.2025.120595. Online ahead of print. ABSTRACT BACKGROUNG AND AIMS: Inflammation is associated with cardiovascular disease development and microvascular dysfunction. The aim of the present study is to test the hypothesis that long-term exposure to chronic inflammation in childhood and adulthood is associated with adverse retinal…

Horm Behav. 2025 Nov 22;177:105862. doi: 10.1016/j.yhbeh.2025.105862. Online ahead of print. ABSTRACT There is a vast amount of research indicating the associations between prenatal and postnatal environmental stress exposures and the human hypothalamic-pituitary-adrenal (HPA) axis functioning in early childhood. However, less is known about the protective factors among these associations.

Int J Gynaecol Obstet. 2025 Nov 20. doi: 10.1002/ijgo.70673. Online ahead of print. ABSTRACT OBJECTIVE: Poor sleep quality in late pregnancy has been identified as a risk factor for operative deliveries. In this study, we investigated the associations between maternal sleep throughout pregnancy and its impact on both the duration…

Eur Thyroid J. 2025 Nov 20:ETJ-25-0260. doi: 10.1530/ETJ-25-0260. Online ahead of print. ABSTRACT Autoimmune hypothyroidism occurs rarely before three years of age. Two siblings were diagnosed with autoimmune hypothyroidism at age five and 16 months, presenting with classic symptoms of hypothyroidism, abnormal thyroid function tests (TSH 200 and 660 mU/L;…

Diabetologia. 2025 Nov 8. doi: 10.1007/s00125-025-06573-6. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: Islet autoimmunity during presymptomatic type 1 diabetes is heterogeneous. We hypothesised that a positive family history of type 1 diabetes is associated with specific characteristics of the autoimmune process resulting in clinical diabetes. In a prospective birth cohort…

Aging Clin Exp Res. 2025 Nov 6;37(1):319. doi: 10.1007/s40520-025-03229-8. ABSTRACT PURPOSE: This study assessed osteoporosis, sarcopenia and osteosarcopenia as risk factors for fractures and mortality during 19-year follow-up. METHODS: We analyzed 2506 individuals aged ≥ 55 from the Finnish Health 2000 Survey. Probable sarcopenia was defined as grip strength <…

J Clin Endocrinol Metab. 2025 Oct 31:dgaf601. doi: 10.1210/clinem/dgaf601. Online ahead of print. ABSTRACT CONTEXT: Autoimmune destruction of beta cells and their functional decline precedes the clinical onset of type 1 diabetes. However, altered alpha-cell function and hyperglucagonemia may contribute to the development of hyperglycemia and ketoacidosis at onset. OBJECTIVE:…

Psychol Med. 2025 Oct 24;55:e316. doi: 10.1017/S0033291725102109. ABSTRACT BACKGROUND: Cardiovascular diseases (CVD) and depression frequently co-occur, yet the biological mechanisms underpinning this comorbidity remain poorly understood. This may reflect complex, non-linear associations across multiple biological pathways. We aimed to identify molecular biomarkers linking depressive symptoms and cardiovascular phenotypes using a…

Eur Child Adolesc Psychiatry. 2025 Oct 15. doi: 10.1007/s00787-025-02865-9. Online ahead of print. ABSTRACT It is well-established in previous research that maternal psychological distress may have adverse effects on child social and emotional development. However, less is known about the environmental protective factors on child outcomes. This study aimed to…