Publications

Atherosclerosis. 2025 Nov 20;412:120595. doi: 10.1016/j.atherosclerosis.2025.120595. Online ahead of print. ABSTRACT BACKGROUNG AND AIMS: Inflammation is associated with cardiovascular disease development and microvascular dysfunction. The aim of the present study is to test the hypothesis that long-term exposure to chronic inflammation in childhood and adulthood is associated with adverse retinal…

Int J Gynaecol Obstet. 2025 Nov 20. doi: 10.1002/ijgo.70673. Online ahead of print. ABSTRACT OBJECTIVE: Poor sleep quality in late pregnancy has been identified as a risk factor for operative deliveries. In this study, we investigated the associations between maternal sleep throughout pregnancy and its impact on both the duration…

Eur Thyroid J. 2025 Nov 20:ETJ-25-0260. doi: 10.1530/ETJ-25-0260. Online ahead of print. ABSTRACT Autoimmune hypothyroidism occurs rarely before three years of age. Two siblings were diagnosed with autoimmune hypothyroidism at age five and 16 months, presenting with classic symptoms of hypothyroidism, abnormal thyroid function tests (TSH 200 and 660 mU/L;…

Diabetologia. 2025 Nov 8. doi: 10.1007/s00125-025-06573-6. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: Islet autoimmunity during presymptomatic type 1 diabetes is heterogeneous. We hypothesised that a positive family history of type 1 diabetes is associated with specific characteristics of the autoimmune process resulting in clinical diabetes. In a prospective birth cohort…

Aging Clin Exp Res. 2025 Nov 6;37(1):319. doi: 10.1007/s40520-025-03229-8. ABSTRACT PURPOSE: This study assessed osteoporosis, sarcopenia and osteosarcopenia as risk factors for fractures and mortality during 19-year follow-up. METHODS: We analyzed 2506 individuals aged ≥ 55 from the Finnish Health 2000 Survey. Probable sarcopenia was defined as grip strength <…

J Clin Endocrinol Metab. 2025 Oct 31:dgaf601. doi: 10.1210/clinem/dgaf601. Online ahead of print. ABSTRACT CONTEXT: Autoimmune destruction of beta cells and their functional decline precedes the clinical onset of type 1 diabetes. However, altered alpha-cell function and hyperglucagonemia may contribute to the development of hyperglycemia and ketoacidosis at onset. OBJECTIVE:…

Psychol Med. 2025 Oct 24;55:e316. doi: 10.1017/S0033291725102109. ABSTRACT BACKGROUND: Cardiovascular diseases (CVD) and depression frequently co-occur, yet the biological mechanisms underpinning this comorbidity remain poorly understood. This may reflect complex, non-linear associations across multiple biological pathways. We aimed to identify molecular biomarkers linking depressive symptoms and cardiovascular phenotypes using a…

Eur Child Adolesc Psychiatry. 2025 Oct 15. doi: 10.1007/s00787-025-02865-9. Online ahead of print. ABSTRACT It is well-established in previous research that maternal psychological distress may have adverse effects on child social and emotional development. However, less is known about the environmental protective factors on child outcomes. This study aimed to…

Lancet Planet Health. 2025 Oct 9:101309. doi: 10.1016/j.lanplh.2025.101309. Online ahead of print. ABSTRACT BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants associated with adverse health outcomes in humans. Although they are associated with autism spectrum disorder and behavioural outcomes, whether PFAS affect brain development is unclear. We…

Diabetes Care. 2025 Oct 9:dc251198. doi: 10.2337/dc25-1198. Online ahead of print. ABSTRACT OBJECTIVE: Childhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first). We studied whether a child’s BMI…