Nature. 2024 Sep 4. doi: 10.1038/s41586-024-07993-x. Online ahead of print. ABSTRACT Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being…
Publications
Publications
Identification and functional characterisation of DNA methylation differences between East- and West-originating Finns
Epigenetics. 2024 Dec;19(1):2397297. doi: 10.1080/15592294.2024.2397297. Epub 2024 Sep 1. ABSTRACT Eastern and Western Finns show a striking difference in coronary heart disease-related mortality; genetics is a known contributor for this discrepancy. Here, we discuss the potential role of DNA methylation in mediating the discrepancy in cardiometabolic disease-risk phenotypes between the…
Osteosarcopenia in Finland: prevalence and associated factors
Arch Osteoporos. 2024 Aug 30;19(1):80. doi: 10.1007/s11657-024-01439-7. ABSTRACT This cross-sectional study investigated osteosarcopenia prevalence and its correlates among 2142 adults aged 55 and older in Finland. Findings show 3.9% had osteosarcopenia, while 13.8% and 11.1% had probable sarcopenia only or osteoporosis only, respectively. Osteosarcopenia was associated with low BMI, impaired…
Longitudinal associations of participation in organized and unorganized sports in youth with physical activity in mid-adulthood: The Young Finns Study
J Sports Sci. 2024 Aug 27:1-9. doi: 10.1080/02640414.2024.2386490. Online ahead of print. ABSTRACT We investigated the longitudinal associations between sports participation patterns in youth and physical activity (PA) in adulthood. PA was self-reported triannually between ages 9-18 (n = 2550, 52% females) and measured by accelerometers in mid-adulthood (n =…
Symptomatic type 1 diabetes is approaching, but when?
J Clin Endocrinol Metab. 2024 Aug 22:dgae578. doi: 10.1210/clinem/dgae578. Online ahead of print. NO ABSTRACT PMID:39171922 | DOI:10.1210/clinem/dgae578…
Childhood family environment and systemic haemodynamics in adulthood: the Cardiovascular Risk in Young Finns Study
Scand J Public Health. 2024 Aug 17:14034948241262185. doi: 10.1177/14034948241262185. Online ahead of print. ABSTRACT AIMS: Childhood family environment is associated with adulthood health behaviours and cardiovascular health, but limited data are available concerning the relationship between childhood family environment and adulthood haemodynamic determinants of blood pressure. We evaluated how childhood…
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis
BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. doi: 10.1136/bmjresp-2023-001630. ABSTRACT OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis…
A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations
Res Sq [Preprint]. 2024 Jul 17:rs.3.rs-4163414. doi: 10.21203/rs.3.rs-4163414/v1. ABSTRACT Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for…
The effect of early life cytomegalovirus infection on the immune profile of children
Clin Immunol. 2024 Jul 25:110330. doi: 10.1016/j.clim.2024.110330. Online ahead of print. ABSTRACT Cytomegalovirus (CMV) infection has a life-long impact on the immune system, particularly on memory T cells. However, the effect of early life CMV infection on the phenotype and functionality of T cells in infants and especially longitudinal changes…
Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth
Int J Cancer. 2024 Jul 22. doi: 10.1002/ijc.35098. Online ahead of print. ABSTRACT Zona pellucida 3 (ZP3) expression is classically found in the ZP-layer of the oocytes, lately shown in ovarian and prostate cancer. A successful ZP3 ovarian cancer immunotherapy in transgenic mice suggested its use as an attractive therapeutic…
