Adolescent weight gain trajectories and their associations with biological aging: a genetically informed study

Int J Obes (Lond). 2026 Aug 12. doi: 10.1038/s41366-026-02194-0. Online ahead of print. ABSTRACT BACKGROUND: High body mass index (BMI) in adolescence is associated with accelerated biological aging, which might predict the onset of obesity-related diseases before they develop. Genetic factors may shape both adolescent BMI and weight trajectories. METHODS:…

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Changes in toothbrushing and factors associated with less than twice daily toothbrushing by the age of four in the FinnBrain Birth Cohort Study

Acta Odontol Scand. 2026 Aug 11;85:549-558. doi: 10.2340/aos.v85.46661. ABSTRACT This study examined toothbrushing and its associated factors in children aged 1-4 years, using data from 306 mother-father-dyads and their 308 children participating in the FinnBrain Birth Cohort Study. Longitudinal multivariable regression analysis was conducted using the generalized estimating equation method…

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Early life and adulthood risk factors for middle age P-wave prolongation and left atrial enlargement

Eur J Prev Cardiol. 2026 Jul 24:zwag366. doi: 10.1093/eurjpc/zwag366. Online ahead of print. ABSTRACT AIMS: P-wave prolongation and left atrial (LA) enlargement are markers of atrial cardiomyopathy and increase the risk for atrial fibrillation, stroke, and mortality. We investigated whether the cumulative burden of cardiovascular risk factors in early life…

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Temporal stability of cardiometabolic risk factors from the perspective of primordial disease prevention in children

J Clin Endocrinol Metab. 2026 Jul 21:dgag285. doi: 10.1210/clinem/dgag285. Online ahead of print. ABSTRACT CONTEXT AND OBJECTIVE: Excess adiposity and circulating lipoprotein lipids in childhood are predictive of cardiometabolic disease in adulthood. We analysed temporal tracking for body mass and lipid biomarkers using population-based time-series to assess the statistical feasibility…

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Genetic architecture and cross-platform validation of apolipoprotein A-IV concentrations

Genome Biol. 2026 Jul 14. doi: 10.1186/s13059-026-04196-7. Online ahead of print. ABSTRACT BACKGROUND: Apolipoprotein A-IV (apoA-IV) plays key roles in lipid metabolism, reverse cholesterol transport, and kidney function, yet its genetic determinants remain poorly defined. We conduct a genome-wide association study (GWAS) meta-analysis of apoA-IV concentrations measured by ELISA in…

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Effect of dietary counselling on educational disparities in cardiometabolic health from childhood to adulthood

Eur J Prev Cardiol. 2026 Jul 15:zwag355. doi: 10.1093/eurjpc/zwag355. Online ahead of print. ABSTRACT AIM: We examined whether parental education was associated with long-term cardiometabolic health and whether the effectiveness of a dietary counselling intervention differed by parental education level, hypothesizing greater effectiveness among highly educated families. METHODS: The study…

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Maternal intake of vitamins A, C, D, and E during pregnancy and the risk of type 1 diabetes in the child: the Norwegian Mother, Father and Child Cohort Study

Am J Clin Nutr. 2026 Jul 10:101431. doi: 10.1016/j.ajcnut.2026.101431. Online ahead of print. ABSTRACT BACKGROUND: Dietary vitamins play a role in antioxidant defense and immunoregulation. However, prospective studies exploring the association between vitamin intakes during pregnancy and the child’s risk of type 1 diabetes are limited. OBJECTIVE: This population-based prospective…

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Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort

Aging Cell. 2026 Jul;25(7):e70626. doi: 10.1111/acel.70626. ABSTRACT DNA methylation-based epigenetic clocks have been highlighted as promising biomarkers of ageing, and they have been shown to robustly predict morbidity and mortality. However, current literature is lacking a formal analysis of the increased prediction accuracy, or the added value, of the epigenetic…

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Depressive symptoms in mid-pregnancy are associated with DNA methylation marks in the placenta

Placenta. 2026 Jul 2;182:267-278. doi: 10.1016/j.placenta.2026.06.020. Online ahead of print. ABSTRACT INTRODUCTION: Maternal depressive symptoms during pregnancy are associated with a range of adverse neurodevelopmental outcomes in offspring. DNA methylation, influenced by both genetic and environmental factors, has been identified as a potential mechanism mediating these associations. Because the placenta…

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