Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics

Pediatr Res. 2026 Jan 15. doi: 10.1038/s41390-025-04726-2. Online ahead of print. ABSTRACT BACKGROUND: Elevated pre-pregnancy body mass index (BMI) and perinatal depressive symptoms have been linked to neonatal alterations in brain structure and function. This study examined associations between neonatal functional brain dynamics, maternal BMI, and perinatal depressive symptoms measured…

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Cardiovascular Risk Factors From Early Childhood and Cognitive Function in Young Adulthood

Pediatrics. 2026 Jan 15:e2025071353. doi: 10.1542/peds.2025-071353. Online ahead of print. ABSTRACT OBJECTIVE: Cardiovascular health promotion in adulthood is crucial for early prevention of cognitive decline, but prior data on the role of promotion starting from infancy are scarce. We studied the associations between cardiovascular risk factors from infancy to young…

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Polygenic risk for schizophrenia predicting test-measured and self-reported cognitive performance in individuals without psychosis

BMC Psychiatry. 2026 Jan 12. doi: 10.1186/s12888-026-07775-x. Online ahead of print. ABSTRACT INTRODUCTION: Schizophrenia is characterized by weaker test-measured cognitive performance, which is partially explained by disease-related secondary factors (after the onset of the disorder) such as side effects of antipsychotics, stigma, or sedentary behavior. We examined whether polygenic risk…

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Familial aggregation of leisure-time physical activity across three generations: The Cardiovascular Risk in Young Finns Study

Scand J Public Health. 2026 Jan 11:14034948251395569. doi: 10.1177/14034948251395569. Online ahead of print. ABSTRACT AIMS: Leisure-time physical activity (LTPA) is known to be hereditary for two generations, but its transmission beyond that is less studied. This study examined LTPA aggregation in three-generation families. METHODS: Data on self-reported LTPA were extracted…

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A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations

HGG Adv. 2026 Jan 10:100566. doi: 10.1016/j.xhgg.2026.100566. Online ahead of print. ABSTRACT Gene-environment interactions may enhance our understanding of blood pressure (BP) biology. We conducted a meta-analysis of multi-population genome-wide association studies of BP traits accounting for gene-depressive symptomatology (DEPR) interactions. Our study included 564,680 adults from 67 cohorts and…

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Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study

Clin Epigenetics. 2026 Jan 3. doi: 10.1186/s13148-025-02037-1. Online ahead of print. ABSTRACT BACKGROUND: To identify blood DNA methylation profiles related to liver steatosis, we performed an EWAS on the presence of ultrasonically-identified liver steatosis in the Young Finns Study (YFS) participants (n = 1529, 33-50y.), and on liver enzyme levels…

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Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals

medRxiv [Preprint]. 2025 Oct 7:2025.10.06.25337440. doi: 10.1101/2025.10.06.25337440. ABSTRACT Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies in…

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Predicting and Explaining Parenting Stress 3 Months After Birth Using Generalized Additive Model

Comput Inform Nurs. 2025 Dec 29. doi: 10.1097/CIN.0000000000001393. Online ahead of print. ABSTRACT The aim of this study was to predict and explain parenting stress at 3 months after the delivery with pregnancy-related features collected in different stages of pregnancy using generalized additive modelling. Pregnant women (n=1138) were recruited for…

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