Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study

Clin Epigenetics. 2026 Jan 3. doi: 10.1186/s13148-025-02037-1. Online ahead of print. ABSTRACT BACKGROUND: To identify blood DNA methylation profiles related to liver steatosis, we performed an EWAS on the presence of ultrasonically-identified liver steatosis in the Young Finns Study (YFS) participants (n = 1529, 33-50y.), and on liver enzyme levels…

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Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals

medRxiv [Preprint]. 2025 Oct 7:2025.10.06.25337440. doi: 10.1101/2025.10.06.25337440. ABSTRACT Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies in…

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Predicting and Explaining Parenting Stress 3 Months After Birth Using Generalized Additive Model

Comput Inform Nurs. 2025 Dec 29. doi: 10.1097/CIN.0000000000001393. Online ahead of print. ABSTRACT The aim of this study was to predict and explain parenting stress at 3 months after the delivery with pregnancy-related features collected in different stages of pregnancy using generalized additive modelling. Pregnant women (n=1138) were recruited for…

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Dietary intake of vitamins A, B, C, D and E and risk of islet autoimmunity and type 1 diabetes in genetically at-risk children: a prospective study from the DIPP birth cohort

Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06635-9. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: In this prospective birth cohort study, we examined whether the dietary intake of A, B, C, D and E vitamins is associated with the risk of islet autoimmunity or type 1 diabetes in children who are genetically at…

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Autoimmune Thyroid Disease in a Cohort of Children With Increased Genetic Susceptibility to Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study

Clin Endocrinol (Oxf). 2025 Dec 15. doi: 10.1111/cen.70070. Online ahead of print. ABSTRACT OBJECTIVE: Clinical autoimmune thyroid disease (AITD), presenting as either hypo- or hyperthyroidism, can occur at any age. Autoantibodies against thyroid peroxidase or thyroglobulin precede the onset of clinical AITD. We aimed to assess factors associated with AITD…

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Association of behaviour-related health risk factors with working life expectancy in adults aged ≥ 50 years: findings from the English Longitudinal Study of Ageing and the Finnish Public Sector Study

Eur J Ageing. 2025 Nov 29. doi: 10.1007/s10433-025-00896-4. Online ahead of print. ABSTRACT BACKGROUND: Behaviour-related health risk factors are associated with an increased risk of early exit from the working life, but their contribution to working life expectancy (WLE) remains unclear. We investigated the associations of obesity, alcohol intake, smoking…

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Differential effects of adolescent health behaviours on adult cardiometabolic health by parental and neighbourhood socioeconomic background

Eur J Public Health. 2025 Nov 22:ckaf212. doi: 10.1093/eurpub/ckaf212. Online ahead of print. ABSTRACT Adolescent healthy behaviours may improve cardiometabolic health in adulthood differently across socioeconomic groups. We aimed to quantify the effects of adolescent healthy behaviours on multiple biomarkers of adult cardiometabolic health by socioeconomic backgrounds. We used a…

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