Maternal intake of vitamins A, C, D, and E during pregnancy and the risk of type 1 diabetes in the child: the Norwegian Mother, Father and Child Cohort Study

Am J Clin Nutr. 2026 Jul 10:101431. doi: 10.1016/j.ajcnut.2026.101431. Online ahead of print. ABSTRACT BACKGROUND: Dietary vitamins play a role in antioxidant defense and immunoregulation. However, prospective studies exploring the association between vitamin intakes during pregnancy and the child’s risk of type 1 diabetes are limited. OBJECTIVE: This population-based prospective…

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Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort

Aging Cell. 2026 Jul;25(7):e70626. doi: 10.1111/acel.70626. ABSTRACT DNA methylation-based epigenetic clocks have been highlighted as promising biomarkers of ageing, and they have been shown to robustly predict morbidity and mortality. However, current literature is lacking a formal analysis of the increased prediction accuracy, or the added value, of the epigenetic…

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Depressive symptoms in mid-pregnancy are associated with DNA methylation marks in the placenta

Placenta. 2026 Jul 2;182:267-278. doi: 10.1016/j.placenta.2026.06.020. Online ahead of print. ABSTRACT INTRODUCTION: Maternal depressive symptoms during pregnancy are associated with a range of adverse neurodevelopmental outcomes in offspring. DNA methylation, influenced by both genetic and environmental factors, has been identified as a potential mechanism mediating these associations. Because the placenta…

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Geographical Pattern of Testicular Cancer Points to Maternal Exposures Behind Increasing Incidence

Int J Cancer. 2026 Jul 4. doi: 10.1002/ijc.70636. Online ahead of print. ABSTRACT Evidence suggests that testicular cancer (TC) originates from germ cell neoplasia in situ arising during fetal development, implying that prenatal environmental exposures may influence disease risk. We investigated whether maternal place of residence during pregnancy is associated…

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The associations of childhood and adolescence psychosocial risks with social relations in midlife

Sci Rep. 2026 Jul 1. doi: 10.1038/s41598-026-58873-5. Online ahead of print. ABSTRACT We examined whether the accumulation of psychosocial risk factors (socioeconomic risks, health behavioural risks, stressful life-events and psycho-emotional risks) in childhood and adolescence contributes to insufficient social relations (loneliness, frequency and heterogeneity of social contacts and social support)…

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Earliest age to detect lifetime cardiometabolic health stratification in children

Atherosclerosis. 2026 Jun 25;419:120833. doi: 10.1016/j.atherosclerosis.2026.120833. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Cardiovascular risk factors such as overweight and high cholesterol in childhood are predictive of high disease risk in adulthood. However, the optimal timing and scope of early prevention remains uncertain due to sparse data. Our aim…

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Retinol, Carotenoid, and Tocopherol Intake and Status, and the Risk of Islet Autoimmunity and Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study

Diabetes Metab Res Rev. 2026 Jul;42(5):e70196. doi: 10.1002/dmrr.70196. ABSTRACT AIMS: To study the associations of dietary intake of A and E vitamins, as well as plasma retinols, carotenoids, and tocopherols in relation to development of islet autoimmunity and progression to T1D. MATERIALS AND METHODS: The Environmental Determinants of Diabetes in…

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Role of resilience in modifying the links between genetic propensity for mental disorders and irritability

J Affect Disord. 2026 Jun 25:122174. doi: 10.1016/j.jad.2026.122174. Online ahead of print. ABSTRACT AIMS: We examined (1) whether polygenic risk scores for schizophrenia (PRSSCZ), major depression (PRSMDD), and posttraumatic stress disorder (PRSPTSD) explain irritability between ages 20 and 50 and (2) whether these associations are modified by early psychosocial resilience.

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Modest Longitudinal Associations Between Parent-Reported Dental Fear at Age 5 and Child-Reported Dental Fear at Age 9: A FinnBrain Birth Cohort Study

Dent J (Basel). 2026 Jun 5;14(6):344. doi: 10.3390/dj14060344. ABSTRACT Background/Objectives: Parent report is often used to assess dental fear in early childhood, but its association with later child-reported dental fear remains unclear. This study primarily examined whether parent-reported dental fear at age 5 was associated with child-reported dental fear at…

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