Neighbourhood socioeconomic disadvantage from childhood to midlife and atherosclerotic SES

Int J Cardiol. 2026 Feb 2:134216. doi: 10.1016/j.ijcard.2026.134216. Online ahead of print. ABSTRACT BACKGROUND: Neighbourhood socioeconomic disadvantage correlates with cardiovascular disease risk. However, its relationship with subclinical atherosclerosis from childhood to midlife is not well-defined. We examined whether cumulative neighbourhood disadvantage is associated with carotid artery plaques, a measure of…

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Changes in hair cortisol during retirement transition: the Finnish retirement and aging study

Compr Psychoneuroendocrinol. 2025 Nov 4;24:100325. doi: 10.1016/j.cpnec.2025.100325. eCollection 2025 Nov. ABSTRACT OBJECTIVES: Retirement is a significant life event involving removal of work stress and changes in other psychological factors. These changes may induce physiological responses in the body, such as changes in levels of the stress hormone cortisol, but no…

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Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B

Elife. 2026 Feb 2;12:RP89068. doi: 10.7554/eLife.89068. ABSTRACT Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases, including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA-DR3 haplotype (DRB1*03:01-DQA1*05:01-DQB1*02:01). Studies…

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Unpredictable maternal signals and developmental profiles of child executive function from infancy to early childhood

Dev Cogn Neurosci. 2026 Jan 9;78:101672. doi: 10.1016/j.dcn.2026.101672. Online ahead of print. ABSTRACT Early executive function (EF) development is crucial for later cognitive and socioemotional outcomes, yet the role of environmental unpredictability, particularly in patterns of maternal sensory signals, remains underexplored. In this longitudinal study, we investigated the associations between…

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A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol

EBioMedicine. 2026 Jan 30;124:106144. doi: 10.1016/j.ebiom.2026.106144. Online ahead of print. ABSTRACT BACKGROUND: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors from de novo biosynthesis.

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Intravenous Glucagon Infusion in the Management of Hypoglycemia in Infants of Diabetic Mothers

Am J Perinatol. 2026 Jan 29. doi: 10.1055/a-2788-2020. Online ahead of print. ABSTRACT This study aimed to evaluate the efficacy and safety of continuous intravenous (IV) glucagon infusion in the management of neonatal hypoglycemia in infants of diabetic mothers (IDMs).This retrospective case-control study included IDMs treated for hypoglycemia at Turku…

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Thyroid autoimmunity and the subsequent development of islet and celiac autoimmunity in the TEDDY study

Am J Epidemiol. 2026 Jan 23:kwag016. doi: 10.1093/aje/kwag016. Online ahead of print. ABSTRACT We aimed to determine if thyroid autoimmunity is associated with a child’s risk for subsequent development of islet or celiac autoantibodies. Children at high genetic risk of type 1 diabetes were followed for thyroid autoimmunity (thyroid peroxidase…

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Aperiodic parameters of the fMRI power spectrum associate with preterm birth and neonatal age

Commun Biol. 2026 Jan 23. doi: 10.1038/s42003-025-09488-5. Online ahead of print. ABSTRACT Perinatal period is a critical time for brain development and premature-born children have an elevated likelihood for neurodevelopmental conditions. While strong associations of structural magnetic resonance imaging with preterm birth and post-menstrual age (PMA) have been reported, results…

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Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics

Pediatr Res. 2026 Jan 15. doi: 10.1038/s41390-025-04726-2. Online ahead of print. ABSTRACT BACKGROUND: Elevated pre-pregnancy body mass index (BMI) and perinatal depressive symptoms have been linked to neonatal alterations in brain structure and function. This study examined associations between neonatal functional brain dynamics, maternal BMI, and perinatal depressive symptoms measured…

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Cardiovascular Risk Factors From Early Childhood and Cognitive Function in Young Adulthood

Pediatrics. 2026 Jan 15:e2025071353. doi: 10.1542/peds.2025-071353. Online ahead of print. ABSTRACT OBJECTIVE: Cardiovascular health promotion in adulthood is crucial for early prevention of cognitive decline, but prior data on the role of promotion starting from infancy are scarce. We studied the associations between cardiovascular risk factors from infancy to young…

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