J Affect Disord. 2026 Jun 25:122174. doi: 10.1016/j.jad.2026.122174. Online ahead of print. ABSTRACT AIMS: We examined (1) whether polygenic risk scores for schizophrenia (PRSSCZ), major depression (PRSMDD), and posttraumatic stress disorder (PRSPTSD) explain irritability between ages 20 and 50 and (2) whether these associations are modified by early psychosocial resilience.

