CTLA4 rs3087243-A-linked haplotype is associated with increased CTLA-4 expression and suppressive function in human regulatory T cells

J Immunol. 2026 Oct 1;215(10):vkag276. doi: 10.1093/jimmun/vkag276. ABSTRACT CTLA-4 is an inhibitory receptor on T cells that limits immune activation by competing with the co-stimulatory receptor CD28 for binding to CD80 and CD86 on antigen-presenting cells. Regulatory T cells (Tregs) employ CTLA-4-mediated transendocytosis as a key suppressive mechanism. Several CTLA4…

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Lipoprotein(a): Particle vs mass and prevalent cardiovascular disease in the cardiovascular risk in Young Finns study population

J Clin Lipidol. 2026 Sep 25:S1933-2874(26)00528-3. doi: 10.1016/j.jacl.2026.09.019. Online ahead of print. ABSTRACT BACKGROUND: Lipoprotein(a) [Lp(a)] can be reported as mass (mg/dL) or particle concentration (nmol/L). Because Lp(a) acts at the particle level, molar concentration may better reflect biologically relevant exposure. OBJECTIVE: To compare molar- and mass-based Lp(a) in relation…

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Device-measured physical activity and sedentary behavior during office versus remote workdays among hybrid workers

Scand J Work Environ Health. 2026 Oct 2:4335. doi: 10.5271/sjweh.4335. Online ahead of print. ABSTRACT OBJECTIVES: Daily sedentary time (SED) has been found to be higher during remote compared to office workdays, but current evidence mostly relies on studies from COVID-19 pandemic times. This study aimed to compare device-measured physical…

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Multi-National Evaluation of Low-Density Lipoprotein Cholesterol Equations in Young Adulthood for Long-Term Risk of Atherosclerotic Cardiovascular Disease

Circ Popul Health Outcomes. 2026 Sep 30:e013678. doi: 10.1161/CIRCOUTCOMES.125.013678. Online ahead of print. ABSTRACT BACKGROUND: Accurate low-density lipoprotein cholesterol (LDL-C) assessment in young adulthood is critical for atherosclerotic cardiovascular disease (ASCVD) prevention, yet the optimal estimation equation remains uncertain. We compared the Friedewald, Martin-Hopkins, and Sampson equations for evaluating long-term…

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Transition to Retirement Impact on Physical Activity: Longitudinal Temporal Trajectories of Frequency and Intensity From the Survey of Health, Aging, and Retirement in Europe

J Phys Act Health. 2026 Sep 23:1-11. doi: 10.1123/jpah.2025-0143. Online ahead of print. ABSTRACT BACKGROUND: Major life course transitions such as retirement may substantially affect lifestyles. Despite the well-established benefits of physical activity (PA) in older ages, evidence on its relationship with retirement remains inconsistent. This study examines the impact…

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Dietary vitamin C intake and the risk of islet autoimmunity and type 1 diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY) Study

Eur J Nutr. 2026 Sep 24;65(7):262. doi: 10.1007/s00394-026-04116-2. ABSTRACT PURPOSE: We explored the associations between vitamin C intake and the risk of islet autoimmunity (IA) and/or type 1 diabetes in genetically at-risk children. Furthermore, we explored associations between vitamin C metabolism-related single nucleotide polymorphisms (SNPs) and type 1 diabetes outcomes.

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Immune proteomic associations with indices of cortical development in 5-year-old children

J Anat. 2026 Sep 10. doi: 10.1111/joa.70225. Online ahead of print. ABSTRACT The immune system has emerged as a critical factor influencing neurodevelopment in offspring. While this is increasingly well-studied in the context of maternal immune activation (MIA), the relationship between postnatal immune activation and brain development in childhood is…

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Predicting Mobility and Functional Recovery After Hip Fracture With Handgrip Strength, Calf Circumference, and the SARC-F Questionnaire

J Am Med Dir Assoc. 2026 Sep 4;27(10):106450. doi: 10.1016/j.jamda.2026.106450. Online ahead of print. ABSTRACT OBJECTIVES: More longitudinal studies of the implications of sarcopenia are needed in patients with hip fractures. This study compared 2 sarcopenia-related measurements and 1 questionnaire-based screening tool and examined their association with rehabilitation outcomes after…

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Ultrasound-detected fatty liver in young adults and long-term risk of atherosclerotic cardiovascular disease: The Young Finns Study

Atherosclerosis. 2026 Aug 24;421:121882. doi: 10.1016/j.atherosclerosis.2026.121882. Online ahead of print. ABSTRACT BACKGROUND: Fatty liver is the most common chronic liver disease globally and is associated with increased cardiovascular risk. Evidence specifically addressing fatty liver and cardiovascular outcomes in young adults from European population-based cohorts remains scarce. METHODS: Fatty liver was…

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