Dietary intake of vitamins A, B, C, D and E and risk of islet autoimmunity and type 1 diabetes in genetically at-risk children: a prospective study from the DIPP birth cohort

Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06635-9. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: In this prospective birth cohort study, we examined whether the dietary intake of A, B, C, D and E vitamins is associated with the risk of islet autoimmunity or type 1 diabetes in children who are genetically at…

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Autoimmune Thyroid Disease in a Cohort of Children With Increased Genetic Susceptibility to Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study

Clin Endocrinol (Oxf). 2025 Dec 15. doi: 10.1111/cen.70070. Online ahead of print. ABSTRACT OBJECTIVE: Clinical autoimmune thyroid disease (AITD), presenting as either hypo- or hyperthyroidism, can occur at any age. Autoantibodies against thyroid peroxidase or thyroglobulin precede the onset of clinical AITD. We aimed to assess factors associated with AITD…

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Association of behaviour-related health risk factors with working life expectancy in adults aged ≥ 50 years: findings from the English Longitudinal Study of Ageing and the Finnish Public Sector Study

Eur J Ageing. 2025 Nov 29. doi: 10.1007/s10433-025-00896-4. Online ahead of print. ABSTRACT BACKGROUND: Behaviour-related health risk factors are associated with an increased risk of early exit from the working life, but their contribution to working life expectancy (WLE) remains unclear. We investigated the associations of obesity, alcohol intake, smoking…

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Differential effects of adolescent health behaviours on adult cardiometabolic health by parental and neighbourhood socioeconomic background

Eur J Public Health. 2025 Nov 22:ckaf212. doi: 10.1093/eurpub/ckaf212. Online ahead of print. ABSTRACT Adolescent healthy behaviours may improve cardiometabolic health in adulthood differently across socioeconomic groups. We aimed to quantify the effects of adolescent healthy behaviours on multiple biomarkers of adult cardiometabolic health by socioeconomic backgrounds. We used a…

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Dynamics of gut metabolome and microbiota maturation during early life

iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21. ABSTRACT Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This study investigates the gut metabolites, including short-chain fatty acids (SCFAs), bile acids (BAs), and…

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Associations of long-term cumulative C-reactive protein and glycoprotein acetyls concentrations in childhood, adolescence and adulthood with adulthood retinal microvascular structure

Atherosclerosis. 2025 Nov 20;412:120595. doi: 10.1016/j.atherosclerosis.2025.120595. Online ahead of print. ABSTRACT BACKGROUNG AND AIMS: Inflammation is associated with cardiovascular disease development and microvascular dysfunction. The aim of the present study is to test the hypothesis that long-term exposure to chronic inflammation in childhood and adulthood is associated with adverse retinal…

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Associations between cumulative family environmental stress exposures and hair cortisol concentrations among 2.5- and 5-year-olds with different social competences

Horm Behav. 2025 Nov 22;177:105862. doi: 10.1016/j.yhbeh.2025.105862. Online ahead of print. ABSTRACT There is a vast amount of research indicating the associations between prenatal and postnatal environmental stress exposures and the human hypothalamic-pituitary-adrenal (HPA) axis functioning in early childhood. However, less is known about the protective factors among these associations.

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