Polygenic risk for schizophrenia predicting test-measured and self-reported cognitive performance in individuals without psychosis

BMC Psychiatry. 2026 Jan 12. doi: 10.1186/s12888-026-07775-x. Online ahead of print. ABSTRACT INTRODUCTION: Schizophrenia is characterized by weaker test-measured cognitive performance, which is partially explained by disease-related secondary factors (after the onset of the disorder) such as side effects of antipsychotics, stigma, or sedentary behavior. We examined whether polygenic risk…

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Familial aggregation of leisure-time physical activity across three generations: The Cardiovascular Risk in Young Finns Study

Scand J Public Health. 2026 Jan 11:14034948251395569. doi: 10.1177/14034948251395569. Online ahead of print. ABSTRACT AIMS: Leisure-time physical activity (LTPA) is known to be hereditary for two generations, but its transmission beyond that is less studied. This study examined LTPA aggregation in three-generation families. METHODS: Data on self-reported LTPA were extracted…

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A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations

HGG Adv. 2026 Jan 10:100566. doi: 10.1016/j.xhgg.2026.100566. Online ahead of print. ABSTRACT Gene-environment interactions may enhance our understanding of blood pressure (BP) biology. We conducted a meta-analysis of multi-population genome-wide association studies of BP traits accounting for gene-depressive symptomatology (DEPR) interactions. Our study included 564,680 adults from 67 cohorts and…

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Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study

Clin Epigenetics. 2026 Jan 3. doi: 10.1186/s13148-025-02037-1. Online ahead of print. ABSTRACT BACKGROUND: To identify blood DNA methylation profiles related to liver steatosis, we performed an EWAS on the presence of ultrasonically-identified liver steatosis in the Young Finns Study (YFS) participants (n = 1529, 33-50y.), and on liver enzyme levels…

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Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals

medRxiv [Preprint]. 2025 Oct 7:2025.10.06.25337440. doi: 10.1101/2025.10.06.25337440. ABSTRACT Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies in…

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Predicting and Explaining Parenting Stress 3 Months After Birth Using Generalized Additive Model

Comput Inform Nurs. 2025 Dec 29. doi: 10.1097/CIN.0000000000001393. Online ahead of print. ABSTRACT The aim of this study was to predict and explain parenting stress at 3 months after the delivery with pregnancy-related features collected in different stages of pregnancy using generalized additive modelling. Pregnant women (n=1138) were recruited for…

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Dietary intake of vitamins A, B, C, D and E and risk of islet autoimmunity and type 1 diabetes in genetically at-risk children: a prospective study from the DIPP birth cohort

Diabetologia. 2025 Dec 19. doi: 10.1007/s00125-025-06635-9. Online ahead of print. ABSTRACT AIMS/HYPOTHESIS: In this prospective birth cohort study, we examined whether the dietary intake of A, B, C, D and E vitamins is associated with the risk of islet autoimmunity or type 1 diabetes in children who are genetically at…

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Autoimmune Thyroid Disease in a Cohort of Children With Increased Genetic Susceptibility to Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study

Clin Endocrinol (Oxf). 2025 Dec 15. doi: 10.1111/cen.70070. Online ahead of print. ABSTRACT OBJECTIVE: Clinical autoimmune thyroid disease (AITD), presenting as either hypo- or hyperthyroidism, can occur at any age. Autoantibodies against thyroid peroxidase or thyroglobulin precede the onset of clinical AITD. We aimed to assess factors associated with AITD…

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