J Clin Endocrinol Metab. 2025 Oct 31:dgaf601. doi: 10.1210/clinem/dgaf601. Online ahead of print. ABSTRACT CONTEXT: Autoimmune destruction of beta cells and their functional decline precedes the clinical onset of type 1 diabetes. However, altered alpha-cell function and hyperglucagonemia may contribute to the development of hyperglycemia and ketoacidosis at onset. OBJECTIVE:…
Publications
Publications
A multilayer network analysis of cardiovascular-depression comorbidity reveals symptom-specific molecular biomarkers
Psychol Med. 2025 Oct 24;55:e316. doi: 10.1017/S0033291725102109. ABSTRACT BACKGROUND: Cardiovascular diseases (CVD) and depression frequently co-occur, yet the biological mechanisms underpinning this comorbidity remain poorly understood. This may reflect complex, non-linear associations across multiple biological pathways. We aimed to identify molecular biomarkers linking depressive symptoms and cardiovascular phenotypes using a…
Participation in early childhood education and care in Finland mitigates the associations between maternal psychological distress and child social and emotional problems at age two
Eur Child Adolesc Psychiatry. 2025 Oct 15. doi: 10.1007/s00787-025-02865-9. Online ahead of print. ABSTRACT It is well-established in previous research that maternal psychological distress may have adverse effects on child social and emotional development. However, less is known about the environmental protective factors on child outcomes. This study aimed to…
Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study
Lancet Planet Health. 2025 Oct 9:101309. doi: 10.1016/j.lanplh.2025.101309. Online ahead of print. ABSTRACT BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants associated with adverse health outcomes in humans. Although they are associated with autism spectrum disorder and behavioural outcomes, whether PFAS affect brain development is unclear. We…
The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2
Diabetes Care. 2025 Oct 9:dc251198. doi: 10.2337/dc25-1198. Online ahead of print. ABSTRACT OBJECTIVE: Childhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first). We studied whether a child’s BMI…
Puberty-Promoting Treatment and Psychosocial Well-Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial
Clin Endocrinol (Oxf). 2025 Oct 6. doi: 10.1111/cen.70039. Online ahead of print. ABSTRACT OBJECTIVE: In boys, constitutional delay of growth and puberty (CDGP) has been associated with diverse negative psychosocial effects. Albeit alleviating distress is one of the main reasons for inducing pubertal development, the impact of puberty-promoting treatment on…
The late chromatoid body component TSSK2 is involved in translational regulation in elongating spermatids in mice
Reproduction. 2025 Oct 3:REP-25-0297. doi: 10.1530/REP-25-0297. Online ahead of print. ABSTRACT IN BRIEF: Temporally regulated translation is critical for late steps of spermatogenesis due to transcriptional silencing during chromatin condensation. This study shows that the function of the cytoplasmic granule, the late chromatoid body, is connected to the translational regulation…
Early life gut microbial and metabolic shifts reflected in stool consistency- a gut transit time proxy
bioRxiv [Preprint]. 2025 Sep 16:2024.06.05.597641. doi: 10.1101/2024.06.05.597641. ABSTRACT Transit time, fluid intake, diet, and overall gut health all influence stool consistency. However, the relationships between the gut microbiota, metabolome (microbial metabolites), and stool consistency in infants and young children remain poorly understood. In this study, we analyzed the microbiota and…
Predictors of Transitions From GADA as the Initial Autoantibody to Multiple Autoantibodies of Type 1 Diabetes in Children at Risk by a Dynamic Prediction Model
Pediatr Diabetes. 2025 Sep 16;2025:8845330. doi: 10.1155/pedi/8845330. eCollection 2025. ABSTRACT Objective: To design a dynamic prediction model for estimating the time of progression from a single glutamic acid decarboxylase autoantibody (GADA) to multiple islet autoantibodies and type 1 diabetes in children, exploring different longitudinally measured risk variables. Research Design and…
Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis
Arthritis Rheumatol. 2025 Jul 16. doi: 10.1002/art.43315. Online ahead of print. ABSTRACT OBJECTIVE: Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive. METHODS: Plasma samples from 110…
