Biosci Rep. 2024 May 3:BSR20240562. doi: 10.1042/BSR20240562. Online ahead of print. ABSTRACT Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is associated with increased risk of neurodevelopmental disorders in exposed offspring. The pathophysiological mechanisms mediating this relationship are currently unknown, and one potential candidate is the anti-angiogenic factor soluble…
Publications
Publications
Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data
BMC Med Inform Decis Mak. 2024 May 2;24(1):116. doi: 10.1186/s12911-024-02521-3. ABSTRACT BACKGROUND: Machine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics data, although these outcomes often exhibit categorical nature and class imbalances. However, little is known about which ML classifier, omics…
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Nat Genet. 2024 Apr 30. doi: 10.1038/s41588-024-01714-w. Online ahead of print. ABSTRACT Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to…
Cohort study on incidence of new-onset type 2 diabetes in patients after bariatric surgery and matched controls
Br J Surg. 2024 Apr 3;111(4):znae105. doi: 10.1093/bjs/znae105. ABSTRACT BACKGROUND: Metabolic bariatric surgery the reduces risk of new-onset type 2 diabetes in individuals with obesity, but it is unclear whether the benefit varies by sex, age, or socioeconomic status. The aim was to assess the risk of new-onset type 2…
Association between anti-capsular IgG levels at birth and risk of invasive group B streptococcus disease in Finnish newborns: a retrospective case-control study
Lancet Microbe. 2024 Apr 25:S2666-5247(24)00038-7. doi: 10.1016/S2666-5247(24)00038-7. Online ahead of print. ABSTRACT BACKGROUND: Group B streptococcus is a major cause of neonatal disease. Natural history studies have linked maternally transferred anti-group B streptococcus capsular polysaccharide antibodies with protection against infant group B streptococcus disease. Previous studies of capsular polysaccharide antibody…
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Nat Genet. 2024 Apr 19. doi: 10.1038/s41588-024-01752-4. Online ahead of print. NO ABSTRACT PMID:38641645 | DOI:10.1038/s41588-024-01752-4…
Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: Cardiovascular Risk in Young Finns Study
Cancer Epidemiol Biomarkers Prev. 2024 Apr 19. doi: 10.1158/1055-9965.EPI-23-1000. Online ahead of print. ABSTRACT BACKGROUND: Lifestyle factors may affect cancer risk. This study aimed to identify whether American Heart Association (AHA) Ideal Cardiovascular Health (ICH) score and its individual variables in youth associate with subsequent cancer incidence. METHODS: Study comprised…
NMR metabolomic modeling of age and lifespan: A multicohort analysis
Aging Cell. 2024 Apr 18:e14164. doi: 10.1111/acel.14164. Online ahead of print. ABSTRACT Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models…
Mother-Infant Interaction and Maternal Postnatal Psychological Distress Associate with Child’s Social-Emotional Development During Early Childhood: A FinnBrain Birth Cohort Study
Child Psychiatry Hum Dev. 2024 Apr 16. doi: 10.1007/s10578-024-01694-2. Online ahead of print. ABSTRACT We studied the effects of mother-infant interaction and maternal pre- and postnatal psychological distress on children’s social-emotional problems and competences, as well as whether interaction quality moderates the association between distress and children’s outcomes. Maternal pre-…
Non-High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events
JAMA. 2024 Apr 12. doi: 10.1001/jama.2024.4819. Online ahead of print. ABSTRACT IMPORTANCE: Elevated non-high-density lipoprotein cholesterol (non-HDL-C; a recommended measure of lipid-related cardiovascular risk) is common in children and increases risk of adult cardiovascular disease (CVD). Whether resolution of elevated childhood non-HDL-C levels by adulthood is associated with reduced risk…
