Cell Rep Med. 2023 Jun 23:101093. doi: 10.1016/j.xcrm.2023.101093. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study…
Publications
Publications
Associations of breastfeeding duration with serum lipid values from infancy until age 20 years – the STRIP study
Scand J Public Health. 2023 Jun 30:14034948231183030. doi: 10.1177/14034948231183030. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: The effect of breastfeeding duration on childhood lipid levels has remained controversial. In this study, we aimed to establish the long-term associations of breastfeeding duration with future levels of total cholesterol, high-density lipoprotein…
Longitudinal patterns of alcohol use and psychological symptoms during COVID-19 pandemic and role of alexithymia: A latent transition analysis in the FinnBrain Birth Cohort Study
J Affect Disord. 2023 Jun 27:S0165-0327(23)00822-4. doi: 10.1016/j.jad.2023.06.056. Online ahead of print. ABSTRACT BACKGROUND: The COVID-19 pandemic has been posing widespread influence on mental well-being. However, research on the dynamic relations between alcohol use and psychological symptoms in the context of the pandemic and the role of alexithymic traits in…
Testicular Cancer: Pathogenesis, Diagnosis and Management with Focus on Endocrine Aspects
2023 Mar 29. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New…
Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis: Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study
Atherosclerosis. 2022 Nov;361:1-9. doi: 10.1016/j.atherosclerosis.2022.10.005. Epub 2022 Oct 8. ABSTRACT AIM: We aimed at identifying the shared biological processes underlying atherosclerosis-osteoporosis co/multimorbidity. METHODS: We performed gene set analysis (GSA) of whole-blood transcriptomic data to identify biological processes shared by the early markers of these two diseases. Early markers of diseases,…
Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts
Dev Psychopathol. 2021 Dec;33(5):1837-1848. doi: 10.1017/s0954579421001012. Epub 2021 Oct 15. ABSTRACT High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research…
Multi-trajectory analysis of changes in physical activity and body mass index in relation to retirement: Finnish Retirement and Aging study
PLoS One. 2022 Dec 1;17(12):e0278405. doi: 10.1371/journal.pone.0278405. eCollection 2022. ABSTRACT BACKGROUND: Physical activity and body mass index (BMI) have been reported to change around retirement. The objective was to examine the concurrent changes in physical activity and BMI around retirement, which have not been studied before. In addition, the associations…
A saturated map of common genetic variants associated with human height
Nature. 2022 Oct;610(7933):704-712. doi: 10.1038/s41586-022-05275-y. Epub 2022 Oct 12. ABSTRACT Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals…
Lipoprotein(a) in Youth and Prediction of Major Cardiovascular Outcomes in Adulthood
Circulation. 2023 Jan 3;147(1):23-31. doi: 10.1161/CIRCULATIONAHA.122.060667. Epub 2022 Nov 28. ABSTRACT BACKGROUND: Elevated lipoprotein(a) [Lp(a)] is a common risk factor for cardiovascular disease outcomes with unknown mechanisms. We examined its potential role in identifying youths who are at increased risk of developing adult atherosclerotic cardiovascular disease (ASCVD). METHODS: Lp(a) levels…
Metabolic trajectories in childhood and adolescence: Effects on risk for schizophrenia
Schizophrenia (Heidelb). 2022 Oct 11;8(1):82. doi: 10.1038/s41537-022-00282-4. ABSTRACT Abnormal glucose and lipid metabolism is common in antipsychotic-naive first-episode patients with schizophrenia, but it is unclear whether these changes can already be seen in premorbid or prodromal period, before the first psychotic episode. We examined insulin, total cholesterol, low-density lipoprotein (LDL)…
