Clin Immunol. 2024 Jul 25:110330. doi: 10.1016/j.clim.2024.110330. Online ahead of print. ABSTRACT Cytomegalovirus (CMV) infection has a life-long impact on the immune system, particularly on memory T cells. However, the effect of early life CMV infection on the phenotype and functionality of T cells in infants and especially longitudinal changes…
Publications
Publications
Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth
Int J Cancer. 2024 Jul 22. doi: 10.1002/ijc.35098. Online ahead of print. ABSTRACT Zona pellucida 3 (ZP3) expression is classically found in the ZP-layer of the oocytes, lately shown in ovarian and prostate cancer. A successful ZP3 ovarian cancer immunotherapy in transgenic mice suggested its use as an attractive therapeutic…
Stimulating leisure-time activities and the risk of dementia: a multi-cohort study
Age Ageing. 2024 Jul 2;53(7):afae141. doi: 10.1093/ageing/afae141. ABSTRACT BACKGROUND: Stimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with…
Early appearance of thyroid autoimmunity in children followed from birth for type 1 diabetes risk
J Clin Endocrinol Metab. 2024 Jul 12:dgae478. doi: 10.1210/clinem/dgae478. Online ahead of print. ABSTRACT PURPOSE: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for…
Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature
Eur Heart J. 2024 Jul 12:ehae423. doi: 10.1093/eurheartj/ehae423. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Retinal microvasculature characteristics predict cardiovascular morbidity and mortality. This study investigated associations of lifelong cardiovascular risk factors and effects of dietary intervention on retinal microvasculature in young adulthood. METHODS: The cohort is derived from…
Paternal adverse childhood experiences are associated with a low risk of atopy in the offspring
Acta Paediatr. 2024 Jul 11. doi: 10.1111/apa.17345. Online ahead of print. ABSTRACT AIM: Parental adverse childhood experiences (ACE) might affect the offspring health through intergenerational inheritance. The aim of this study was to investigate how paternal ACE associate with offspring sensitisation and allergic rhinitis (AR). METHODS: The study included 590…
Consortium Profile: The Methylation, Imaging and NeuroDevelopment (MIND) Consortium
medRxiv [Preprint]. 2024 Jun 25:2024.06.23.24309353. doi: 10.1101/2024.06.23.24309353. ABSTRACT Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain…
Temporal Alterations in CD8+ T Cells During the Progression from Stage 1 to Stage 3 Type 1 Diabetes
Diabetes. 2024 Jul 5:db240159. doi: 10.2337/db24-0159. Online ahead of print. ABSTRACT CD8+ T cells are perceived to play a major role in the pathogenesis of type 1 diabetes (T1D). In this study, we characterized the function and phenotype of circulating CD8+ memory T cells in samples from individuals at different…
Implementing ABCD studyⓇ MRI sequences for multi-site cohort studies: Practical guide to necessary steps, preprocessing methods, and challenges
MethodsX. 2024 Jun 1;12:102789. doi: 10.1016/j.mex.2024.102789. eCollection 2024 Jun. ABSTRACT Large multi-site studies that combine magnetic resonance imaging (MRI) data across research sites present exceptional opportunities to advance neuroscience research. However, scanner or site variability and non-standardised image acquisition protocols, data processing and analysis pipelines can adversely affect the reliability…
Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth
Cell Rep. 2024 Jul 3;43(7):114430. doi: 10.1016/j.celrep.2024.114430. Online ahead of print. ABSTRACT Cancer cells undergo major epigenetic alterations and transcriptomic changes, including ectopic expression of tissue- and cell-type-specific genes. Here, we show that the germline-specific RNA helicase DDX4 forms germ-granule-like cytoplasmic ribonucleoprotein granules in various human tumors, but not in…
