iScience. 2024 Aug 9;27(10):110704. doi: 10.1016/j.isci.2024.110704. eCollection 2024 Oct 18. ABSTRACT We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using…
Publications
Publications
Predicting early-stage coronary artery disease using machine learning and routine clinical biomarkers improved by augmented virtual data
Eur Heart J Digit Health. 2024 Aug 9;5(5):542-550. doi: 10.1093/ehjdh/ztae049. eCollection 2024 Sep. ABSTRACT AIMS: Coronary artery disease (CAD) is a highly prevalent disease with modifiable risk factors. In patients with suspected obstructive CAD, evaluating the pre-test probability model is crucial for diagnosis, although its accuracy remains controversial. Machine learning…
Food Consumption and Risk of Islet Autoimmunity and Type 1 Diabetes in Children at Increased Genetic Susceptibility for Type 1 Diabetes
J Nutr. 2024 Sep 21:S0022-3166(24)01035-6. doi: 10.1016/j.tjnut.2024.09.018. Online ahead of print. ABSTRACT BACKGROUND: Prospective longitudinal evidence considering the entire childhood food consumption in relation to development of islet autoimmunity (IA or) type 1 diabetes is lacking. OBJECTIVES: We studied the associations of consumption of various foods and their combinations with…
Reciprocal relationships between a child’s engagement with faces and mother-child interaction at 8, 30, and 60 months
Dev Psychol. 2024 Sep 23. doi: 10.1037/dev0001831. Online ahead of print. ABSTRACT Prioritized attention to faces can be viewed as an early-developing marker of social engagement. This behavior is closely linked with early interactions, but there has been little research examining the longitudinal associations between social engagement and parent-child interaction.
Cognitive performance from childhood to old age and intergenerational correlations in the multigenerational Young Finns Study
J Neurol. 2024 Sep 22. doi: 10.1007/s00415-024-12693-7. Online ahead of print. ABSTRACT BACKGROUND: Cognitive performance changes during the lifespan, but the information is gathered from studies on separate age cohorts. Computerized neurocognitive testing enables efficient and similar assessments for all ages. We investigated (i) the effect of age at different…
Sleep duration and sleep loss during pregnancy: a longitudinal FinnBrain birth cohort study
Arch Gynecol Obstet. 2024 Sep 20. doi: 10.1007/s00404-024-07727-4. Online ahead of print. ABSTRACT PURPOSE: To investigate sleep duration and sleep loss during antenatal period and assess associative factors, including maternal characteristic and mood symptoms. METHODS: A cohort of 3038 women was enrolled. Self-reported sleep duration and sleep loss, the latter…
Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children
Pediatr Allergy Immunol. 2024 Sep;35(9):e14240. doi: 10.1111/pai.14240. ABSTRACT BACKGROUND: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear. METHODS: We analyzed data from 3176 mother-child pairs in a prospective birth cohort study. Maternal anthropometric measurements in…
Life-period associations of body mass index with adult carotid intima-media thickness: The Bogalusa heart study and the cardiovascular risk in young Finns study
Prev Med. 2024 Sep 5:108128. doi: 10.1016/j.ypmed.2024.108128. Online ahead of print. ABSTRACT OBJECTIVE: Child and adult body mass index (BMI) associates with adult carotid artery intima-media thickness (cIMT). However, the relative contribution of BMI at different life-periods on adult cIMT has not been quantified. This study aimed to determine the…
A Clinical Tool to Relate Youth Risk Factors to Adult Cardiovascular Events and Type 2 Diabetes: The i3C Consortium
J Pediatr. 2024 Sep 2:114277. doi: 10.1016/j.jpeds.2024.114277. Online ahead of print. ABSTRACT OBJECTIVE: To translate data relating childhood cardiovascular (CV) risk factors and adult CV disease and type 2 diabetes mellitus (T2DM) to clinically actionable values. STUDY DESIGN: A prospective observational study (n=38,589) in the International Childhood Cardiovascular Cohort (i3C)…
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
Nature. 2024 Sep 4. doi: 10.1038/s41586-024-07993-x. Online ahead of print. ABSTRACT Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being…
