Publications

BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. doi: 10.1136/bmjresp-2023-001630. ABSTRACT OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis…

Res Sq [Preprint]. 2024 Jul 17:rs.3.rs-4163414. doi: 10.21203/rs.3.rs-4163414/v1. ABSTRACT Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for…

Clin Immunol. 2024 Jul 25:110330. doi: 10.1016/j.clim.2024.110330. Online ahead of print. ABSTRACT Cytomegalovirus (CMV) infection has a life-long impact on the immune system, particularly on memory T cells. However, the effect of early life CMV infection on the phenotype and functionality of T cells in infants and especially longitudinal changes…

Int J Cancer. 2024 Jul 22. doi: 10.1002/ijc.35098. Online ahead of print. ABSTRACT Zona pellucida 3 (ZP3) expression is classically found in the ZP-layer of the oocytes, lately shown in ovarian and prostate cancer. A successful ZP3 ovarian cancer immunotherapy in transgenic mice suggested its use as an attractive therapeutic…

Age Ageing. 2024 Jul 2;53(7):afae141. doi: 10.1093/ageing/afae141. ABSTRACT BACKGROUND: Stimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with…

J Clin Endocrinol Metab. 2024 Jul 12:dgae478. doi: 10.1210/clinem/dgae478. Online ahead of print. ABSTRACT PURPOSE: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for…

Eur Heart J. 2024 Jul 12:ehae423. doi: 10.1093/eurheartj/ehae423. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Retinal microvasculature characteristics predict cardiovascular morbidity and mortality. This study investigated associations of lifelong cardiovascular risk factors and effects of dietary intervention on retinal microvasculature in young adulthood. METHODS: The cohort is derived from…

Acta Paediatr. 2024 Jul 11. doi: 10.1111/apa.17345. Online ahead of print. ABSTRACT AIM: Parental adverse childhood experiences (ACE) might affect the offspring health through intergenerational inheritance. The aim of this study was to investigate how paternal ACE associate with offspring sensitisation and allergic rhinitis (AR). METHODS: The study included 590…

medRxiv [Preprint]. 2024 Jun 25:2024.06.23.24309353. doi: 10.1101/2024.06.23.24309353. ABSTRACT Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain…

Diabetes. 2024 Jul 5:db240159. doi: 10.2337/db24-0159. Online ahead of print. ABSTRACT CD8+ T cells are perceived to play a major role in the pathogenesis of type 1 diabetes (T1D). In this study, we characterized the function and phenotype of circulating CD8+ memory T cells in samples from individuals at different…